Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death

Zaiter, Jamila; Hibot, Achraf; Hafid, Abderrafia; Khouili, Mostafà; Neves, Cláudia M. B.; Simões, Mário M. Q.; Neves, Margarida; Faustino, Maria A. F.; Dağcı, Taner; Saso, Luciano; Armağan, Güliz

doi:10.1016/j.ejmech.2020.113140

European Journal of Medicinal Chemistry

2021

DOI: 10.1016/j.ejmech.2020.113140

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Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death

Jamila Zaiter

Achraf Hibot

Abderrafia Hafid

et al.

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Cited by 11 publications

References 30 publications

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Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones

Fang

et al. 2021

Angewandte Chemie

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Ac atalytic system-controlled divergent reaction strategy was here reported to construct four types of intriguing spiroheterocyclic skeletons from simple and readily available starting materials via ap recise chemical bond activation/[n + 1] annulation cascade.T he tetraazaspiroheterocyclic and trizazspiroheterocyclic scaffolds could be independently constructed by aselective NÀNbond activation/[n + 1] annulation cascade,aC(sp 2 )-H activation/[4+ +1] annulation and an ovel tandem C(sp 2 )-H/C(sp 3 )ÀHbond activation/[4+ +1] annulation strategy,a long with ab road scope of substrates,m oderate to excellent yields and valuable transformations.M ore importantly,inthese transformations,weare the first time to capture aN À Nb ond activation and aC (sp 3 ) À Hb ond activation of pyrazolidinones under different catalytic system. Scheme 1. Previous work and this work.

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Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones

Fang

et al. 2021

Angewandte Chemie

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show abstract

Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones

Fang

et al. 2021

Angew Chem Int Ed

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A catalytic system‐controlled divergent reaction strategy was here reported to construct four types of intriguing spiroheterocyclic skeletons from simple and readily available starting materials via a precise chemical bond activation/[n+1] annulation cascade. The tetraazaspiroheterocyclic and trizazspiroheterocyclic scaffolds could be independently constructed by a selective N−N bond activation/[n+1] annulation cascade, a C(sp2)‐H activation/[4+1] annulation and a novel tandem C(sp2)‐H/C(sp3)−H bond activation/[4+1] annulation strategy, along with a broad scope of substrates, moderate to excellent yields and valuable transformations. More importantly, in these transformations, we are the first time to capture a N−N bond activation and a C(sp3)−H bond activation of pyrazolidinones under different catalytic system.

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Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction

Tanaka,

Vécsei

2024

J Neural Transm

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Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death

Cited by 11 publications

References 30 publications

Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones

Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones

Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones

Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction

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