Evaluation of the Biotic Ligand Model relative to other site-specific criteria derivation methods for copper in surface waters with elevated hardness

Genderen, Eric Van; Gensemer, Robert W.; Smith, C.F.; Santore, Robert C.; Ryan, Adam C.

doi:10.1016/j.aquatox.2007.02.024

Cited by 23 publications

(22 citation statements)

References 19 publications

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“…In addition, these authors reported a calculated LC50 of 1.2 μM of copper in contrast to the value of 13.82 μM calculated in our experiments, a difference of an order of magnitude (Seok et al, 2006). There are several possible explanations for these differences such as the strain of fi sh used (AB strain in our study versus a non-typifi ed strain), ion composition of the media (E3 in our experiments versus Ringer's solution) and water hardness (Long et al, 2004;Van Genderen et al, 2007).…”

Section: Discussioncontrasting

confidence: 52%

Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae

et al. 2011

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Copper is an essential ion that forms part of the active sites of many proteins. At the same time, an excess of this metal produces free radicals that are toxic for cells and organisms. Fish have been used extensively to study the effects of metals, including copper, present in food or the environment. It has been shown that different metals induce different adaptive responses in adult fi sh. However, until now, scant information has been available about the responses that are induced by waterborne copper during early life stages of fi sh. Here, acute toxicity tests and LC50 curves have been generated for zebrafi sh larvae exposed to dissolved copper sulphate at different concentrations and for different treatment times. We determined that the larvae incorporate and accumulate copper present in the medium in a concentrationdependent manner, resulting in changes in gene expression. Using a transgenic fi sh line that expresses enhanced green fl uorescent protein (EGFP) under the hsp70 promoter, we monitored tissue-specifi c stress responses to waterborne copper by following expression of the reporter. Furthermore, TUNEL assays revealed which tissues are more susceptible to cell death after exposure to copper. Our results establish a framework for the analysis of whole-organism management of excess external copper in developing aquatic animals.

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Section: Discussioncontrasting

confidence: 52%

Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae

et al. 2011

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“…The effect of hardness on copper toxicity might reflect competition between hardness ions and copper for binding sites on gill surface. Calcium appears to be more protective than magnesium against copper toxicity to fish [45]. Calcium binds to the gill surface and controls the permeability of the membrane and the integrity of the ionoregulatory function [46].…”

Section: Discussionmentioning

confidence: 99%

“…Although test water used by Villar et al [44] had lower dissolved organic carbon and alkalinity concentrations, hardness seems to have a strong influence on copper toxicity to C. decemmaculatus . Van Genderen et al [45] found that increments in water hardness from 200 to 1000 mg CaCO 3 L −1 , achieved by increasing concentration of calcium (magnesium held constant at 30 mg L −1 ), increased 96 h LC50 to larval P. promelas . Some studies have suggested that the molar ratio between calcium and magnesium may be more important than their absolute concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have suggested that the molar ratio between calcium and magnesium may be more important than their absolute concentrations. The calcium-to-magnesium molar ratio in the Pilcomayo River water is 1.45, and studies reported that hardness consisting primarily of calcium (molar ratios of >1) is protective of both fish [19, 23] and invertebrates [45]. However, hardness consisting primarily of magnesium (Ca : Mg molar ratios of ≤1) has only been shown to be important for invertebrates [22].…”

Section: Discussionmentioning

confidence: 99%

“…The effects of hardness on aquatic biota toxicity due to metals in some cases are misinterpreted by correlations with alkalinity, pH, and/or other ionic constituents. Van Genderen et al [45] found that the relationship between alkalinity and LC50 values for P. promelas in the natural waters tested was not significant, but analysis of laboratory water quality data demonstrated a significant positive correlation. Lauren and MacDonald [24] similarly concluded that cupric ion and copper hydroxo complexes, but not copper carbonate complexes, were toxic.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Measured Copper Toxicity toCnesterodon decemmaculatus(Pisces: Poeciliidae) and Predicted by Biotic Ligand Model in Pilcomayo River Water: A Step for a Cross-Fish-Species Extrapolation

Casares

Cabo²,

Seoane³

et al. 2012

Journal of Toxicology

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In order to determine copper toxicity (LC50) to a local species (Cnesterodon decemmaculatus) in the South American Pilcomayo River water and evaluate a cross-fish-species extrapolation of Biotic Ligand Model, a 96 h acute copper toxicity test was performed. The dissolved copper concentrations tested were 0.05, 0.19, 0.39, 0.61, 0.73, 1.01, and 1.42 mg Cu L−1. The 96 h Cu LC50 calculated was 0.655 mg L−1 (0.823 − 0.488). 96-h Cu LC50 predicted by BLM for Pimephales promelas was 0.722 mg L−1. Analysis of the inter-seasonal variation of the main water quality parameters indicates that a higher protective effect of calcium, magnesium, sodium, sulphate, and chloride is expected during the dry season. The very high load of total suspended solids in this river might be a key factor in determining copper distribution between solid and solution phases. A cross-fish-species extrapolation of copper BLM is valid within the water quality parameters and experimental conditions of this toxicity test.

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Ecological Toxicology of Engineered Carbon Nanoparticles

Roberts

Otter

2009

Advanced Nanomaterials

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Evaluation of the Biotic Ligand Model relative to other site-specific criteria derivation methods for copper in surface waters with elevated hardness

Cited by 23 publications

References 19 publications

Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae

Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae

Measured Copper Toxicity toCnesterodon decemmaculatus(Pisces: Poeciliidae) and Predicted by Biotic Ligand Model in Pilcomayo River Water: A Step for a Cross-Fish-Species Extrapolation

Ecological Toxicology of Engineered Carbon Nanoparticles

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