Evaluation of the biological and wound healing activities of Centaurea virgata

Aksoy, Halil

doi:10.33808/marusbed.789734

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…lycaonica, the ethyl acetate fraction of the ethanol extract of C. virgata was found to be more active in DPPH (IC 50 = 138.7 μg/mL) and ABTS radical scavenging activity. This fraction was also rich in phenolic compounds . In a study, C. drabifolia subsp.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Composition, In Vitro Antimicrobial, Antioxidant, and Enzyme Inhibition Activities, and In Silico Molecular Docking and Dynamics Simulations of Centaurea lycaonica: A Computational and Experimental Approach

et al. 2023

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Centaurea lycaonica is a local endemic species from the Centaurea L. genus. The Centaurea species has a wide range of usage in treating diseases in folk medicine. There are limited biological activity studies on this species in the literature. This study investigated enzyme inhibition and antimicrobial activity, antioxidant effect, and chemical content of extract and fractions of C. lycaonica. Enzyme inhibition activity was tested by α-amylase, αglucosidase, and tyrosinase enzyme inhibition methods and antimicrobial activity by the microdilution method. The antioxidant activity was investigated using DPPH • , ABTS •+ , and FRAP tests. The chemical content was determined by LC-MS/MS. The methanol extract showed the highest activity for α-glucosidase and α-amylase, even surpassing the positive control acarbose, with IC 50 values of 56.333 ± 0.986 and 172.800 ± 0.816 μg/mL, respectively. Additionally, the ethyl acetate fraction also exhibited high activity for α-amylase with an IC 50 value of 204.067 ± 1.739 μg/mL and tyrosinase with an IC 50 value of 213.900 ± 1.553 μg/mL. Moreover, this extract and fraction were found to have the highest total phenolic and flavonoid contents and antioxidant activity. Additionally, LC-MS/MS analyses of active extract and fraction revealed mainly the presence of phenolic compounds and flavonoids. In silico molecular docking and molecular dynamics simulation studies of determining compounds apigenin and myristoleic acid, common in CLM and CLE extracts and active against α-glucosidase and α-amylase, were performed. In conclusion, methanol extract and ethyl acetate fraction showed potential enzyme inhibition and antioxidant activity as a natural agent. Molecular modeling studies corroborate the findings of in vitro activity analyses.

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Section: Discussionmentioning

confidence: 99%

“…This fraction was also rich in phenolic compounds. 46 In a study, C. drabifolia subsp. drabifolia and C. lycopifolia extracts were observed in terms of the TPC (18.33–32.84 mg GAE /g extract ) and TFC content (2.88–22.39 mgRE/g extract ) and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition, In Vitro Antimicrobial, Antioxidant, and Enzyme Inhibition Activities, and In Silico Molecular Docking and Dynamics Simulations of Centaurea lycaonica: A Computational and Experimental Approach

et al. 2023

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“…There are study examples showing that A. hippocastanum seed extracts have anticancer effects and inhibit proliferation. As the cell proliferation phase progresses, fibroblasts become the predominant cells at the wound site and play an important role in wound contraction to restore the integrity of injured tissue (Aksoy, 2020). Especially, for the wound-healing phase, fibroblast concentration, proliferation and migration are very significant (Addis et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening and in vitro assessments of antioxidant and cytotoxic potentials of extracts from Aesculus hippocastanum L. green fruit mesocarps

Çelik

Aslantürk

2023

International Journal of Secondary Metabolite

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In this study, the in vitro antioxidant and cytotoxic effects of water and methanol extracts obtained from the green fruit mesocarp of Aesculus hippocastanum L. (Hippocastanaceae) were investigated. Phytochemical content of the methanol extract and the water extract were determined by qualitative methods; antioxidant activity was determined by DPPH free radical scavenging test, and total antioxidant capacity was determined by phosphomolybdate test. The effects of the extracts on proliferation and cell viability of BJ normal human foreskin fibroblasts were also evaluated by the WST-8 cell viability test. Qualitative phytochemical screening results showed that the methanol extract contains phenols, tannins, flavonoids, and saponins, but no alkaloids and anthraquinones. On the other hand, phenols, flavonoids, anthraquinone, and saponins were found in the water extract, tannins and alkaloids could not be detected. In addition, an increase in antioxidant activity was also observed with each increasing concentration of methanol and water extract. When the antioxidant capacity and free radical scavenging activity of methanol and water extracts were compared, it was determined that the methanol extract was more effective than that the water extract. The WST-8 trial results showed that both water and methanol extracts obtained from the green fruit mesocarp of A. hippocastanum did not have cytotoxic effects on BJ cells, on the contrary, treatment concentrations of 10, 20 and, 30 µgmL-1 increased cell proliferation significantly at the 24-hour work.

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The methanol extract of Centaurea depressa M. Bieb. -Containing nanoemulsion formulation: In vitro characterization and scratch assay

Guven,

Ugur Kaplan,

Yesilyurt

et al. 2024

Journal of Drug Delivery Science and Technology

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Evaluation of the biological and wound healing activities of Centaurea virgata

Cited by 3 publications

References 21 publications

Phytochemical Composition, In Vitro Antimicrobial, Antioxidant, and Enzyme Inhibition Activities, and In Silico Molecular Docking and Dynamics Simulations of Centaurea lycaonica: A Computational and Experimental Approach

Phytochemical Composition, In Vitro Antimicrobial, Antioxidant, and Enzyme Inhibition Activities, and In Silico Molecular Docking and Dynamics Simulations of Centaurea lycaonica: A Computational and Experimental Approach

Phytochemical screening and in vitro assessments of antioxidant and cytotoxic potentials of extracts from Aesculus hippocastanum L. green fruit mesocarps

The methanol extract of Centaurea depressa M. Bieb. -Containing nanoemulsion formulation: In vitro characterization and scratch assay

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