Evaluation of the Biological Activity of Folic Acid-Modified Paclitaxel-Loaded Gold Nanoparticles

Ren, Bin; Cai, Zhong-Chao; Zhao, Xue‐Jie; Li, Linsong; Zhao, Mei‐Xia

doi:10.2147/ijn.s322856

Cited by 12 publications

(3 citation statements)

References 53 publications

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“…Therefore, we found that the prepared Au/Gd@FA NCs had some photothermal conversion ability and could promote ROS production in tumor cells. Photothermal effects enhance tumor cells, with significant killing effects, while photogenerated intracellular ROS (such as singlet oxygen) can increase the biological damage of exposed cells through gold-enhanced singlet oxygen photogeneration [ 42 , 43 ]. To further clarify the influence of Au/Gd@FA NCs entering tumor cells under laser irradiation to produce a large number of ROS, leading to the death of tumor cells.…”

Section: Resultsmentioning

confidence: 99%

Ultra-Small and Metabolizable Near-Infrared Au/Gd Nanoclusters for Targeted FL/MRI Imaging and Cancer Theranostics

Dong

Wang

et al. 2022

Biosensors

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Tumor accurate imaging can effectively guide tumor resection and accurate follow-up targeted therapy. The development of imaging-stable, safe, and metabolizable contrast agents is key to accurate tumor imaging. Herein, ultra-small and metabolizable dual-mode imaging probe Au/Gd@FA NCs is rationally engineered by a simple hydrothermal method to achieve accurate FL/MRI imaging of tumors. The probes exhibit ultra-small size (2.5–3.0 nm), near-infrared fluorescence (690 nm), high quantum yield (4.4%), and a better T1 nuclear magnetic signal compared to commercial MRI contrast agents. By modifying the folic acid (FA) molecules, the uptake and targeting of the probes are effectively improved, enabling specific fluorescence imaging of breast cancer. Au/Gd@FA NCs with good biosafety were found to be excreted in the feces after imaging without affecting the normal physiological metabolism of mice. Intracellular reactive oxygen species (ROS) increased significantly after incubation of Au/Gd@FA NCs with tumor cells under 660 nm laser irradiation, indicating that Au/Gd@FA NCs can promote intracellular ROS production and effectively induce cell apoptosis. Thus, metabolizable Au/Gd@FA NCs provide a potential candidate probe for multimodal imaging and tumor diagnosis in clinical basic research. Meanwhile, Au/Gd@FA NCs mediated excessive intracellular production of ROS that could help promote tumor cell death.

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Section: Resultsmentioning

confidence: 99%

Ultra-Small and Metabolizable Near-Infrared Au/Gd Nanoclusters for Targeted FL/MRI Imaging and Cancer Theranostics

Dong

Wang

et al. 2022

Biosensors

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“…Folic acid interacts with cell membrane folate receptors that are widely expressed in cancer cell membranes then Mo loaded AuNPs are endocytosed and encapsulated releasing Mo. [33][34][35] On the other side, the role of AuNPs as drug carriers is being enhanced by the near-infrared (NIR) light exposure. NIR light is a light with wavelength ranging from 600-1000 mm.…”

Section: Discussionmentioning

confidence: 99%

Potential of Moringa oleifera extract-incorporated with folic acid-conjugated gold nanoparticles as an oral squamous cell carcinoma therapy by modulating intrinsic apoptotic pathway: A narrative review

Nugraha¹,

Sosiawan²,

Anwar³

et al. 2022

World J. Adv. Res. Rev.

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Background: Oral squamous cell carcinoma (OSCC) is the most common oral cancer worldwide. Surgery, radiotherapy and chemotherapy are the most common treatments, despite their side effects including toxicity, metastasis and multidrug resistance, thus evoking the need to develop safer treatment. Moringa oleifera (Mo) acts as anticancer agent but has poor bioavailability then incorporated with folic acid-conjugated gold nanoparticles (AuNPs) as drug carriers may enhance the action of Mo in OSCC treatment. Purpose: To describe the potential of Mo extract incorporated with folic acid-conjugated AuNPs as an OSCC therapy by modulating intrinsic apoptosis pathway. Review: Mo-AuNPs was injected to the body and reached the target cell. Folic acid in AuNPs bound to folic acid receptors in the cell membrane thus promoting endocytosis and encapsulation of Mo. AuNPs along with irradiation using near infrared light converted light into heat thus promoting pro-apoptotic protein release. This condition was also supported by Mo's ability to downregulate Akt thus upregulating Bad. Bad induces translocation of Bax into the outer mitochondrial membrane then induces the opening of mitochondrial pores. This condition manifests in formation of apoptosomes thus activating caspase-3 and inducing formation of apoptotic bodies. Conclusion: Mo extract-incorporated with folic acid-conjugated AuNPs may potential as an OSCC therapy by modulating intrinsic apoptosis pathway.

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“…Studies have also shown that GNPs may possess certain targeting properties, as demonstrated by the fact that GNPs selectively act on heparin-binding proteins, such as EGFR and VEGFR-2 ( Mukherjee et al, 2005 ; Huang et al, 2021 ; Zhao et al, 2022 ). In addition, it improves the precise delivery and bioavailability of drugs by covalently and non-covalently binding and transporting drug molecules ( Kim et al, 2012 ; Ren et al, 2021 ). Currently, numerous in vitro and ex vivo studies have almost demonstrated that the core components of AuNP do not possess significant biological toxicity, but their coating stabilizers, such as cetyltrimethylammonium bromide (CTAB), may present a risk of toxic effects on the organism ( Li et al, 2014 ; Zhao et al, 2022 ).…”

Section: Biocompatibility and Safety Of Nanomaterialsmentioning

confidence: 99%

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma

et al. 2022

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Neuroblastoma (NB), as the most common extracranial solid tumor in childhood, is one of the critical culprits affecting children’s health. Given the heterogeneity and invisibility of NB tumors, the existing diagnostic and therapeutic approaches are inadequate and ineffective in early screening and prognostic improvement. With the rapid innovation and development of nanotechnology, nanomedicines have attracted widespread attention in the field of oncology research for their excellent physiological and chemical properties. In this review, we first explored the current common obstacles in the diagnosis and treatment of NB. Then we comprehensively summarized the advancements in nanotechnology-based multimodal synergistic diagnosis and treatment of NB and elucidate the underlying mechanisms. In addition, a discussion of the pending challenges in biocompatibility and toxicity of nanomedicine was conducted. Finally, we described the development and application status of nanomaterials against some of the recognized targets in the field of NB research, and pointed out prospects for nanomedicine-based precision diagnosis and therapy of NB.

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Evaluation of the Biological Activity of Folic Acid-Modified Paclitaxel-Loaded Gold Nanoparticles

Cited by 12 publications

References 53 publications

Ultra-Small and Metabolizable Near-Infrared Au/Gd Nanoclusters for Targeted FL/MRI Imaging and Cancer Theranostics

Ultra-Small and Metabolizable Near-Infrared Au/Gd Nanoclusters for Targeted FL/MRI Imaging and Cancer Theranostics

Potential of Moringa oleifera extract-incorporated with folic acid-conjugated gold nanoparticles as an oral squamous cell carcinoma therapy by modulating intrinsic apoptotic pathway: A narrative review

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma

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