Evaluation of the automated fluorescent immunoassay system anti-hepatitis C virus assay for the detection of hepatitis C virus infection

Waheed, Usman; Hwang, Min-Woong; Saba, Noore; Hong, Sangjin; Saeed, Muhammad; Wazeer, Akhlaaq; Arshad, Muhammad; Usman, Javaid; Zaheer, Hasan Abbas

doi:10.4103/gjtm.gjtm_39_19

Cited by 1 publication

(2 citation statements)

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“…Before donation, potential donors were required to answer a detailed universal donor health questionnaire (Annexure A), which included data regarding their general health, life style, current or past febrile illness, weight loss, chronic disease, unusual or excessive bleeding, drug history, dental procedure, previous blood donation or transfusion, sexual history and high‐risk behaviours followed by a short general physical examination [11]. Vitals (temperature, blood pressure, pulse) and weight were also recorded.…”

Section: Methodsmentioning

confidence: 99%

“…The reality of TTI testing is starkly different in low-and lower middle-income countries like Pakistan. In most centres across Pakistan, TTI testing is being performed by rapid devices with variable sensitivities [9][10][11]. Unsafe blood transfusions thus form a major risk factor for the spread of TTIs like hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV) and syphilis.…”

Section: Introductionmentioning

confidence: 99%

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Degree of blood safety of voluntary non‐remunerated versus replacement blood donations: A multi‐centre study of the large cohort of blood donors from two provinces of Pakistan

Jamal,

Mansoor,

Ali

et al. 2023

Vox Sanguinis

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Background and ObjectivesVoluntary non‐remunerated blood donors (VNRBDs) are recognized as being crucial for the safety and sustainability of national blood supplies. Systems based on replacement donors (RDs) pose high risks of transfusion transmissible infections (TTIs). Currently, only 10%–13% of blood donations are voluntary in Pakistan. No large‐scale studies have been conducted to objectively evaluate the impact of the mode of donation on the frequency of TTIs, a gap this study aimed to fill.Materials and MethodsThe study was conducted at the Indus Hospital, Karachi. Data from a total of 591,820 blood donations were included from 1 October 2017 to 30 May 2021 and evaluated for type of donations and results of TTI testing, primarily performed on Architect i2000SR (Abbott). The TTIs tested include hepatitis B virus, hepatitis C virus, human immunodeficiency virus, syphilis and malaria.ResultsA total of 477,938 (80.7%) RDs and 113,882 (19.3%) VNRBDs were screened. Among these, 53,590 (9.06%) were positive for TTIs. There were 10.2% positive RDs (10.08–10.25 95% confidence interval [CI]) while 4.4% in VNRBDs (4.29–4.53 95% CI). Co‐infections were observed in 2367 (0.4%) RDs, while 159 (0.02%) in VNRBDs. Geographically, the highest frequency of TTIs was observed in semi‐urban areas of Sindh (11.2%) and Punjab (9.6%). A site‐wise comparison of TTIs in RD versus VNRBD showed significant differences (p‐value 0.00).ConclusionRDs are associated with higher frequencies of TTIs, compared with VNRBD. However, the study was unable to assess whether the significant difference was related to individual risk or repeat/first time status of the donors. Other important variables affecting frequency are the catchment area of the blood donors in Pakistan. Urban areas have less prevalence than semi‐urban areas.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%