“…Blood safety remains a paramount public health concern, and health authorities maintain a high level of vigilance to prevent transfusion-transmitted infections (TTIs) [ 1 ]. Rigorous policies, including healthy donor selection, pathogen detection, and pathogen reduction in donated blood, are crucial post-donation safety measures [ 2 ]. Historically, the universal implementation of enzyme immunoassays marked the first generation of blood screening tests in modern blood banks, significantly reducing the transmission of blood pathogens.…”