Evaluation of the association between a single-nucleotide polymorphism of bone morphogenetic proteins 5 gene and risk of knee osteoarthritis

Ac, Sharma; Rn, Srivastava; Srivastava,; Agrahari, Ashok Kumar; Singh, Ajai; Parmar, Devendra

doi:10.4103/jpgm.jpgm_450_16

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Sharma et al . [ 10 ] analyzed genotypic frequencies in Indian men and women. They found a 5.41- and 16.42-fold increased risk of KOA in men and women, respectively, when carrying CT genotype, while the risk is 3.42 and 5.08 fold, respectively, when carrying TT genotype compared with CC genotype.…”

Section: Discussion and C Onclusionmentioning

confidence: 99%

Gender differences in osteoarthritis of knee: An Indian perspective

Thati¹

2021

J Mid-life Health

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Introduction: The global burden of knee osteoarthritis (KOA) is on the rise with advancing age, as life expectancy is improving worldwide. The literature shows a higher prevalence and incidence of KOA in women. The gender differences are seen not only in the developing world but also in the developed world. KOA at advanced stage can be quite disabling affecting the individuals' functioning capacity. The available treatment modalities can improve the quality of life significantly. The aim of this review is to study the gender differences in epidemiological and clinical aspects of KOA in Indian population. Methods: The keywords “knee osteoarthritis, Gender, India,” “knee osteoarthritis, Sex, India,” and “knee osteoarthritis, Prevalence, India” are used for data search for retrieving data from Indian studies in MEDLINE and Google Scholar. The broad inclusion criteria were clinical and radiological diagnosis of KOA, inclusive of both men and women and excluded articles with rheumatoid arthritis, inflammatory arthritis, and secondary causes of arthritis. Results: A total of 18 articles were found to fulfill the broad inclusive criteria. Majority of the articles were cross-sectional prevalence studies either done in a community setup or in tertiary care hospitals. The overall prevalence of KOA in these studies ranges from 27.1% to 66.1%, depending on the lower age limit of the study population. Postmenopausal women are affected more than premenopausal women. High body mass index, hypertension, diabetes mellitus, and osteoporosis were the common comorbid conditions. Discussion & Conclusion: The gender difference in the incidence and prevalence is seen in several cross-sectional studies and case series in the Indian literature. However, there is a paucity of data on clinical presentation, progression of the diseases, disability scoring at various stages of the KOA, and management.

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Section: Discussion and C Onclusionmentioning

confidence: 99%

Gender differences in osteoarthritis of knee: An Indian perspective

Thati¹

2021

J Mid-life Health

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“…The mRNA expression of aggrecan (AGC) and Col2A signifying chondrogenic differentiation was highest where sustained BMP2 is delivered via BMP-coacervate [50]. Both BMP -2 and 7 appeared promising disease-modifying agents for OA patients and are currently under phase-II trial [51,52]. Human MSC, including ADMSCs, treated with BMP-4, 6, and 9 modulate in vitro cartilage development [46].…”

Section: Bone Morphogenetic Protein (Bmp) Induced Cartilage Formationmentioning

confidence: 99%

“…Human MSC, including ADMSCs, treated with BMP-4, 6, and 9 modulate in vitro cartilage development [46]. Recently, in a case-control study, a significant association of rs1470527 and rs9382564 polymorphism of BMP -5 gene with human OA-Knee has been demonstrated; this also may be a potential therapeutic target for OA [52].…”

Section: Bone Morphogenetic Protein (Bmp) Induced Cartilage Formationmentioning

confidence: 99%

Emerging and New Treatment Options for Knee Osteoarthritis

Siddiq

Clegg

Jansen

et al. 2022

CRR

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: Osteoarthritis (OA) is the most prevalent type of arthritis worldwide, resulting in pain and often chronic disability and a significant burden on healthcare systems globally. Non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, intra-articular corticosteroid injections are of little value in the long term, and opioids may have ominous consequences. Radiotherapy of knee OA has no added value. Physical therapy, exercises, weight loss, and lifestyle modifications may give pain relief, improve physical functioning and quality of life. However, no single treatment has regenerating potential for damaged articular cartilage. Due to a better understanding of osteoarthritis, innovative new treatment options have been developed. In this narrative review, we focus on emerging OA knee treatments, relieving symptoms, and regenerating damaged articular cartilage that includes intra-articular human serum albumin, conventional disease-modifying anti-rheumatic drugs (DMARDs), lipid-lowering agents (statin), nerve growth factors antagonists, bone morphogenetic protein, fibroblast growth factors, Platelet-Rich Plasma (PRP), Mesenchymal Stem Cells (MSC), exosomes, interleukin-1 blockers, gene-based therapy, and bisphosphonate.

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“…BMP5 is a bone morphogenetic protein known to promote chondrocyte differentiation, and mutations within this gene have been associated with osteoarthritis. 75 The upregulation of BMP5 appears to be necessary in the physiological repair pathway required for RCT healing. One high-quality study found BMP5 to be upregulated in torn supraspinatus or infraspinatus tendon tissue that successfully healed after surgical repair of RCTs at 1 year, as compared with tendons with failed healing.…”

Section: Growth Factor Genesmentioning

confidence: 99%

Polymorphisms and alterations in gene expression associated with rotator cuff tear and healing following surgical repair: a systematic review

Mousley

Hill-Buxton

Gill

et al. 2021

Journal of Shoulder and Elbow Surgery

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Background: Rotator cuff tears (RCTs) are a common cause of shoulder disability, yet both conservative and surgical treatment strategies can lead to poor results in some patient populations. Enhanced understanding of the genetic processes associated with RCTs can assist in the development of more effective management options and help predict individual responses to surgical treatment. This systematic review analyzes the current literature on the genetic footprint associated with RCTs and interprets these findings to enhance the current understanding of RCT pathogenesis, potential treatment regimens, and prognostic biomarkers of outcomes after surgical repair. Methods: A systematic search of the Embase, PubMed, and Web of Science electronic databases was performed. Medical Subject Headings (MeSH) and Emtree index terms were formulated from the concept terms ''rotator cuff tear,'' ''genetics,'' and ''human,'' and synonyms of these concepts were applied to the Web of Science search. Articles were screened against predefined inclusion and exclusion criteria. Eligible studies compared gene expression patterns and genetic polymorphisms between cases (with RCTs) and controls (without RCTs). Quality assessment was performed with studies being rated as high, moderate, or poor quality. A modified bestevidence synthesis was applied, and studies were determined to be of strong, moderate, or limited evidence. Results: The search identified 259 articles. Of these studies, 26 were eligible for review. Two studies were considered poor quality; 15 studies, moderate quality; and 9 studies, high quality. Analysis of these articles found that RCTs were associated with alterations in genes that code for the extracellular matrix, cell apoptosis, immune and inflammatory responses, and growth factor pathways. In particular, there was strong evidence of a significant association between RCTs and the genes MMP3, TNC, and ESRRB. Strong evidence of an association between BMP5 upregulation and successful healing after surgical repair was also found. Conclusion: This review provides strong evidence of an genetic association with RCTs. The genotype and gene expression patterns detailed within this review can assist in deciphering the biological mechanisms resulting in RCTs, as well as predicting an individual's Institutional review board approval was not required for this systematic review.

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Evaluation of the association between a single-nucleotide polymorphism of bone morphogenetic proteins 5 gene and risk of knee osteoarthritis

Cited by 5 publications

References 21 publications

Gender differences in osteoarthritis of knee: An Indian perspective

Gender differences in osteoarthritis of knee: An Indian perspective

Emerging and New Treatment Options for Knee Osteoarthritis

Polymorphisms and alterations in gene expression associated with rotator cuff tear and healing following surgical repair: a systematic review

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