Evaluation of the antiulcerogenic activity profile of a flavonol diglucoside from Equisetum palustre L.

Yeşilada, Erdem; Gürbüz, İlhan

doi:10.1016/j.jep.2010.05.011

Cited by 21 publications

(19 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ulcerative lesions have been detected histopathologically based on severe focal extensive superficial epithelial damage, desquamation of focal epithelium, focal hemorrhages/congestions, inflammatory cell infiltration, and necrosis of gastric glands and on the fundus after treatment with the HCl/EtOH mixture (Horiuchi, Wachi, & Seyama, 2010; Oyagi et al., 2010; Sánchez et al., 2006; Yesilada & Gurbuz, 2010). Changes in the histopathological images have been used as a valuable criteria index to confirm the gastroprotective effects of various candidates including medicinal herbs (Graziani et al., 2005; Oyagi et al., 2010; Yesilada & Gurbuz, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Changes in the histopathological images have been used as a valuable criteria index to confirm the gastroprotective effects of various candidates including medicinal herbs (Graziani et al., 2005; Oyagi et al., 2010; Yesilada & Gurbuz, 2010). In our results, HCl/EtOH‐associated microscopic ulcerative lesions were markedly inhibited by pretreatment with RA 100 mg/kg and by treatment with all three doses of FBe in a dose‐dependent manner.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

View full text Add to dashboard Cite

This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…This may be hypothesized that rutin protects against aspirin-pylorus ligation induced gastric ulcers, does not modify the endogenous PGs disturbed due to the ethanol administration (Guerrero et al, 1994). But kaempferol-3-O-β-glucopyranoside was found to improve the cytoprotection against HCl-ethanol induced ulcers by altering the gastric mucosa (Yesilada & Gurbuz, 2010). Further the activity might have been potentiated by β-sitosterol-3-O-β-glucopyranoside, which is well known for its gastroprotective activity.…”

Section: Discussionmentioning

confidence: 99%

Role ofBlepharis maderaspatensisandAmmannia bacciferaplant extracts onin vitrooxygen radical scavenging, secretion of gastric fluid and gastroprotection on ulcer induced rats

Rajasekaran¹,

Sivakumar

Darlinquine

2012

Pharmaceutical Biology

View full text Add to dashboard Cite

“…The ulcerogenic effect was investigated as described in a previous publication 44 . The animals were sacrificed with an overdose of diethyl ether 270 min after the administration of the compounds.…”

Section: Gastric Ulcerogenic Effectmentioning

confidence: 99%

Design and synthesis of stable n-[2-(aryl/heteroaryl substituted)ethyl] propanamide derivatives of (s)-ketoprofen and (s)-ibuprofen as non-ulcerogenic anti-inflammatory and analgesic agents

Berk¹,

Bender²,

Küpeli³

et al. 2016

actapharm

View full text Add to dashboard Cite

Evaluation of the antiulcerogenic activity profile of a flavonol diglucoside from Equisetum palustre L.

Cited by 21 publications

References 13 publications

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Role ofBlepharis maderaspatensisandAmmannia bacciferaplant extracts onin vitrooxygen radical scavenging, secretion of gastric fluid and gastroprotection on ulcer induced rats

Design and synthesis of stable n-[2-(aryl/heteroaryl substituted)ethyl] propanamide derivatives of (s)-ketoprofen and (s)-ibuprofen as non-ulcerogenic anti-inflammatory and analgesic agents

Contact Info

Product

Resources

About