Evaluation of the Antiproliferative Activity of Diterpene Isonitriles from the Sponge <i>Pseudoaxinella flava</i> in Apoptosis-Sensitive and Apoptosis-Resistant Cancer Cell Lines

Lamoral-Theys, Delphine; Fattorusso, Ernesto; Mangoni, Alfonso; Perinu, Cristina; Kiss, Róbert; Costantino, Valeria

doi:10.1021/np2005055

Cited by 26 publications

(34 citation statements)

References 23 publications

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“…To make sure that the anticancer effects are processed by cytotoxic or cytostatic pathways, the researchers used quantitative videomicroscopy as an approach to study the structure and bioactivity relationship. The quantitative videomicroscopy observation proved that diterpene isonitrile (46) is active through cytotoxic-related mechanisms [27].…”

Section: Terpenoidsmentioning

confidence: 94%

Anticancer agents from marine sponges

Zhou

Al-Kareef

et al. 2014

Journal of Asian Natural Products Research

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Marine sponges are currently one of the richest sources of anticancer active compounds found in the marine ecosystems. More than 5300 different known metabolites are from sponges and their associated microorganisms. To survive in the complicated marine environment, most of the sponge species have evolved chemical means to defend against predation. Such chemical adaptation produces many biologically active secondary metabolites including anticancer agents. This review highlights novel secondary metabolites in sponges which inhibited diverse cancer species in the recent 5 years. These natural products of marine sponges are categorized based on various chemical characteristics.

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Section: Terpenoidsmentioning

confidence: 94%

Anticancer agents from marine sponges

Zhou

Al-Kareef

et al. 2014

Journal of Asian Natural Products Research

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“…Marine sponges have been considered as an excellent source of marine natural products since the 1950s, with about 4851 compounds described to date, contributing to nearly 30% of all marine natural products discovered so far [67,68,69,70]. Several sponges show anti-diabetes properties, e.g., inhibition of GSK-3β, α-glucosidase, PTP1B, dipeptidyl peptidase IV or protection of the beta pancreatic cells.…”

Section: Marine Macroorganisms With Anti-diabetes Propertiesmentioning

confidence: 99%

Marine Organisms with Anti-Diabetes Properties

Lauritano

Ianora

2016

Marine Drugs

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Diabetes is a chronic degenerative metabolic disease with high morbidity and mortality rates caused by its complications. In recent years, there has been a growing interest in looking for new bioactive compounds to treat this disease, including metabolites of marine origin. Several aquatic organisms have been screened to evaluate their possible anti-diabetes activities, such as bacteria, microalgae, macroalgae, seagrasses, sponges, corals, sea anemones, fish, salmon skin, a shark fusion protein as well as fish and shellfish wastes. Both in vitro and in vivo screenings have been used to test anti-hyperglycemic and anti-diabetic activities of marine organisms. This review summarizes recent discoveries in anti-diabetes properties of several marine organisms as well as marine wastes, existing patents and possible future research directions in this field.

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“…Among marine organisms, the sponges’ holobiome is one of the richest marine sources of secondary metabolites [8,9,10,11] and often provides skeletons with no counterpart in the terrestrial environment. However, no pyrone polypropionates have been isolated so far from a marine sponge.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea

et al. 2018

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The organic extract of the Caribbean sponge Smenospongia aurea has been shown to contain an array of novel chlorinated secondary metabolites derived from a mixed PKS-NRPS biogenetic route such as the smenamides. In this paper, we report the presence of a biogenetically different compound known as smenopyrone, which is a polypropionate containing two γ-pyrone rings. The structure of smenopyrone including its relative and absolute stereochemistry was determined by spectroscopic analysis (NMR, MS, ECD) and supported by a comparison with model compounds from research studies. Pyrone polypropionates are unprecedented in marine sponges but are commonly found in marine mollusks where their biosynthesis by symbiotic bacteria has been hypothesized and at least in one case demonstrated. Since pyrones have recently been recognized as bacterial signaling molecules, we speculate that smenopyrone could mediate inter-kingdom chemical communication between S. aurea and its symbiotic bacteria.

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Evaluation of the Antiproliferative Activity of Diterpene Isonitriles from the Sponge Pseudoaxinella flava in Apoptosis-Sensitive and Apoptosis-Resistant Cancer Cell Lines

Cited by 26 publications

References 23 publications

Anticancer agents from marine sponges

Anticancer agents from marine sponges

Marine Organisms with Anti-Diabetes Properties

Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea

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