Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae)

Da, Ollo; Yerbanga, Serge; Traoré, Maminata; Coulibaly,; Koama, Benjamin Kouliga; Kabré, Zachari; Tamboura, S; Dakuyo, Z.; Sekhoacha, Mamello; Matsabisa, Motlalepula G.; Nikiema, Jean‐Baptiste; Ouédraogo, Jean‐Bosco; Ouédraogo, GA

doi:10.3923/pjbs.2016.171.178

Cited by 6 publications

(2 citation statements)

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“…Moreover, Woradulayapinij et al [124] showed slight inhibition action of ethanolic extracts on HIV type 1. Studies carried out by Da et al [125] revealed no significant changes in weight, tissues morphology, biochemical and hematological at doses above or equal to 2779.5 mg/kg body weight. Quinones and terpenes extract from Cassia alata significantly displayed in vitro antiplasmodial activity against Plasmodium falciparum [126].…”

Section: Ethnomedical and Pharmacological Evidencementioning

confidence: 88%

Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

Roger

Yougouda

Guidawa

et al. 2020

JMHE

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COVID-19 is a severe acute respiratory syndrome-related corona-virus SARS-CoV-2, that constitutes a pandemic threat to global public health. Unfortunately, there are no specific available therapies. This research work presents the ﬁndings of an investigation on traditional Cameroonian remedies of respiratory tract infections, malaria and viral infections, and also recipes that could serve as a baseline for the prevention, alleviate symptoms, treatment and perhaps may help for the anti-COVID-19 drugs discovery. Data on the medicinal plants were collected from traditional healers, Cameroonian medicinal plants books, the internet, and in addition to our personal experience as researchers and herbalists. Details of 85 plant species used to manage these three mentioned diseases in Cameroon and their pharmacological properties are recorded. Due to their ethnomedicinal uses and pharmacological activities, twenty-eight (28) plant species and 13 recipes are suggested for COVID-19 prevention, alleviate symptoms, treatment and baseline for anti-COVID-19 drug discovery. Amongst the proposed plants we have the following, Curcuma longa, Azadirachta indica, Zingiber officinale, Allium sativum and Ocimum gratissimum which were reported to possess certain inhibition properties against COVID-19 protease.

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Section: Ethnomedical and Pharmacological Evidencementioning

confidence: 88%

Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

Roger

Yougouda

Guidawa

et al. 2020

JMHE

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show abstract

“…Interestingly, other plant species in the genus Cassia have been validated as possessing antiplasmodial activities. Cassia siamea [37], Cassia occidentalis [38], Cassia nigricans [39], Cassia singueana, [40] and Cassia alata [41] have all been validated as possessing promising antiplasmodial activities. For some of these plants, some compounds responsible for the antiplasmodial activities have been isolated [42].…”

Section: Discussionmentioning

confidence: 99%

Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of Cassia nodosa Buch.-Ham. (Leguminosae)

Afu

Laryea

Borquaye

2020

Journal of Chemistry

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Medicinal plants are used worldwide to treat various diseases. However, scientific validation of the therapeutic potential of most medicinal plants is absent, and little to no information on their potential toxicity exists. It is therefore important to assess the efficacy and toxicity of various medicinal plants commonly used in traditional herbal medicine. The main goal of this study was to evaluate the efficacy and toxicity of the ethanolic extract of Cassia nodosa, a plant used in the treatment of fever, cold, gastric pain, diabetes mellitus, and malaria in Ghana. The stem bark extract of Cassia nodosa was obtained by cold maceration. Following phytochemical examination via standard procedures, the extract was screened for antiplasmodial, anti-inflammatory, and antioxidant activities. The extract was also evaluated for acute oral toxicity and its toxicity to the liver and kidney of rats. Phytochemicals present in the extract included sterols, alkaloids, tannins, glycosides, and coumarins. In the in vitro antiplasmodial activity test, the Cassia nodosa extract showed moderate antiplasmodial activity with an IC50 value of 23.98 ± 2.07 µg/ml. An ED50 value of 8.52 ± 2.83 mg/kg in the anti-inflammatory test indicated that the Cassia nodosa extract administered orally was very active in reducing inflammation. The total antioxidant capacity of the extract was determined to be 48.49 ± 5.24 gAAE/100 g with the total phenolic content being 28.48 ± 3.13 (gGAE/100 g) extract. In the DPPH radical scavenging assay, the concentration required for 50% inhibition of DPPH radical was found to be 78.71 ± 6.84 µg/mL. There was a gradual increase in the body weight of rats in both treated and control groups during the acute toxicity test. Clinical biochemical tests did not show any significant differences between control and treated groups of animals in terms of liver and renal functions, 14 days after administration of Cassia nodosa extracts. Taken together, these results provide scientific validation for the use of the plant in traditional medicine.

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Medicinal plants from West Africa used as antimalarial agents: an overview

Aubouy

Camara

Haddad

2022

Medicinal Plants as Anti-Infectives

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Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae)

Abstract: The dichloromethane/methanol leaf extract of Cassia alata had a good to moderate in vitro and in vivo antiplasmodial activity and was found to have low toxicity at high doses in tested animals.

Cited by 6 publications

References 0 publications

Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of Cassia nodosa Buch.-Ham. (Leguminosae)

Medicinal plants from West Africa used as antimalarial agents: an overview

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