Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of Schisandra chinensis Extracts and Their Applicability in Skin Care Product

Abstract

Plant extracts have been widely used for skin care for many centuries, and nowadays, they are commonly applied for the development and enrichment of new cosmetic preparations. The present study aimed the assessment of the biological activity of aqueous Schisandra chinensis extracts as a potential ingredient of skin care products. The aspects studied involved the ability to neutralize free radicals, impact on viability and metabolism of keratinocytes, as well as tyrosinase inhibitory potential. Our study showed that aqueous S. chinensis extracts have a positive effect on keratinocyte growth and have high antioxidant potential and strong tyrosinase inhibitory activity. UPLC-MS analysis revealed that three groups of phenolic compounds were predominant in the analyzed extract, including lignans, phenolic acids and flavonoids and protocatechiuc and p-coumaryl quinic acids were predominant. Moreover, microwave-assisted extraction, followed by heat reflux extraction, was the most effective for extracting polyphenols. Furthermore, a prototypical natural body washes gel formulation containing the previously prepared extracts was developed. The irritation potential and viscosity were assessed for each of the formulations. The study demonstrated that the addition of these extracts to body wash gel formulations has a positive effect on their quality and may contribute to a decrease in skin irritation. In summary, S. chinensis aqueous extracts can be seen as an innovative ingredient useful in the cosmetic and pharmaceutical industry.

Essential oil from Citrus depressa peel exhibits antimicrobial, antioxidant and cancer chemopreventive effects

“…The skin microbiota acts as a protective barrier against invasion, proliferation, and infection of alien and pathogenic microorganisms 1 . With an emphasis on personal appearance, there is an increasing demand for beauty and healthcare products that effectively target a variety of skin concerns, including aging, wrinkles, freckles, hydration and skin cancer prevention 2 . Modern consumers prefer products formulated with natural ingredients to avoid skin irritation and chemical damage, at the same time as minimizing environmental impact 3 .…”

“…1 With an emphasis on personal appearance, there is an increasing demand for beauty and healthcare products that effectively target a variety of skin concerns, including aging, wrinkles, freckles, hydration and skin cancer prevention. 2 Modern consumers prefer products formulated with natural ingredients to avoid skin irritation and chemical damage, at the same time as minimizing environmental impact. 3 Furthermore, the integration of phytochemicals with antibacterial properties in care products can extend their useful life at the same time as serving as natural preservatives.…”

Anti-Inflammatory and Protective Effects of Water Extract and Bioferment from Sambucus nigra Fruit in LPS-Induced Human Skin Fibroblasts

“…Cell cytotoxicity was also analyzed using a neutral red dye (Sigma Aldrich, St. Louis, MO, USA) according to the methodology previously described by Zagórska-Dziok et al [ 57 ]. As in the case of the AB assay, both cell types were placed in 96-well plates and cultured for 24 hours.…”

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

“…The aqueous extracts of S. chinensis were analyzed using HPLC–MS. In addition to lignans, phenolic acids and flavonoids, as well as protocatechiuc and p-coumaril quinic acids were found to be predominant ( 31 ). There are two major categories of flavonoids identified: Quercetin derivatives, including glucosides, galactosides, and rutinosides and Kaempferol derivatives, including rutinoside and glucoside ( 31 ).…”