Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats

Hepatoprotective effect of aqeous methanolic extract of <i>Rumex dentatus</i> in paracetamol induced hepatotoxicity in mice

“…Preliminary phytochemical studies showed the presence of tannins, saponins, flavonoids, terpenoids, cardiac glycosides and alkaloids. Hepatoprotective action is found in cinnamic acid (Simonyan, 1993), ferulic acid (Srinivasan et al, 2007), saponins, (Kumar et al, 2011;Gujrati et al, 2007), syringic acid (Itoh et al, 2009) alkaloids (Gujrati et al, 2007;Vijayan et al, 2003), vinillin (Makni et al, 2011), tannins (Sathaya et al, 2011, anthraquinones (Arosio et al, 2008) and flavonoids (Vijay and Padmaa, 2011;Sahreen et al, 2011).…”

Development of drug-loaded chitosan–vanillin nanoparticles and its cytotoxicity against HT-29 cells

“…3-Methoxy-4-hydroxybenzaldehyde (vanillin) is a flavouring agent which has been widely used in cosmetics, drink and food (Ho et al, 2011). In addition, it has been reported that vanillin exhibits many bioactive properties (Zhang, 2004;Makni et al, 2011;Tai et al, 2011). There were some reports on the preparation of chitosan microspheres using vanillin as crosslinking reagent in references (Li et al, 2006), but few studies on the preparation of chitosan nanoparticles by crosslinking with vanillin.…”

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

“…Numerous studies have indicated that hepatic damage induced by CCl 4 is caused by the accumulation of CCl 4 in hepatic parenchymal cells that are metabolically activated by cytochrome P-450 dependent monoxygenases to form metabolites of trichloromethyl free radicals (CCl 3 •) that cause lipid peroxidation and hepatocellular membrane damage. This process is followed by the release of growth factors, inflammatory mediators, and prostaglandins from activated hepatic macrophages that potentiate CCl 4 -induced hepatic injury (15,24,25). The ability of a hepatoprotective drug to alleviate the injurious effects or conserve normal hepatic physiological mechanisms affected by a hepatotoxin is the index of its protective effects (26).…”

“…The body has an effective mechanism to inhibit and neutralize free radical-induced damage using a set of endogenous antioxidant enzymes. When the balance between ROS production and antioxidant defense is destroyed, oxidative stress results, which deregulates cellular function and leads to various pathological conditions (25). Antioxidants can suppress free radical production, which makes them crucial for protection of the liver from chemical-induced damage through their stabilization of the antioxidant systems in the cell (28).…”