Evaluation of the antioxidant activity and the healing action of the ethanol extract of Calotropis procera bark against surgical wounds

Tsala, David Emery; Nga, Nnanga; Ndzana, Martin Thiery Bella; Mballa, Bienvenue Therese; Dimo, Théophile

doi:10.5455/jice.20141211071136

Cited by 32 publications

(23 citation statements)

References 17 publications

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“…The ethanolic extract of the bark of Calotropis procera was evaluated for the antioxidant potential and the wound-healing effect using excision and incision wound on normal and dexamethasone-suppressed wound-healing rodent models. It revealed a potential wound-healing agent due to improved collagen deposition and reduced inflammatory reaction [112,113].…”

Section: Other Plant Species Used In Wound Healingmentioning

confidence: 99%

Natural Compounds for Wound Healing

Georgescu¹,

Marinas²,

Popa³

et al. 2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Many plants or plant-derived compounds with high levels of antioxidants and antiinflammatory, immunomodulatory, and antimicrobial properties could be of great benefit for wound healing. Several studies have documented the use of plant extracts for the development of bioactive wound dressings. The purpose of this chapter is to give an update about the vegetal and bee products, which can be used as bioactive substances in wound dressings or in other formulations for wound healing. The adverse effects of plant and bee extracts, such as contact allergies, are also presented. In order to better exploit the huge reservoir of pharmacologically active plant-derived compounds and extracts, standardized methodology and clinical trials are necessary to give more concrete evidence supporting the use of traditional medicine in wound management.

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Section: Other Plant Species Used In Wound Healingmentioning

confidence: 99%

Natural Compounds for Wound Healing

Georgescu¹,

Marinas²,

Popa³

et al. 2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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“…6,7 Ethanol extract of C. gigantea root can more quickly heal wounds in rats. 8 The methanol extract of C. gigantea root bark in chloroform has antitumor activity against carcinoma cells in mice. Ethyl acetate extract from roots of C. gigantea collected in Meherchandi, Bangladesh contains terpenoid and steroidal compounds and showed cytotoxic activity against Artemia salina with an IC 50 value of 29.56 μg/ml.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity and Hepatotoxicity Evaluation of Methanol Extract of Root Bark of Calotropis gigantea in Rats

Hasballah

Sarong

Rusly

et al. 2018

Dhaka Univ. J. Pharm. Sci

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Many studies of root extract of Calotropis gigantea have been done to prove its potential as anticancer, antimicrobial, etc. agent C. gigantea plant itself is very easy to grow in tropical countries. However, studies of acute toxicity of C. gigantea root extract has not been performed.The purpose of this research was to know the safety level, the chemical constituents, and the acute toxicity of methanol extract of C. gigantea root bark given orally on Rattus norvegicus in rats. C. gigantea root bark was extracted by using methanol. The methanol extract was suspended in 1% sodium carboxymethyl cellulose (CMC) and administered orally by gavage (1250, 2500 and 5000 mg/kg) in separate groups. On the day of fifteen, all animals were anesthetized and some selected vital organs were excised, weighed and macroscopically examined. The liver was assessed histopathologically. There were no lethal effects, behavioral changes and no significant change in body and organ weights compared to control after the administration of the extracts. Thus, the value of LD50 for oral administration of methanol extracts from root bark of C. gigantea was larger than 5000 mg/kg. Methanol extract of C. gigantea root bark must be considered safe enough as none of the rats were died along the study. But, it can damage the hepatic cell, if given in higher dose. Dhaka Univ. J. Pharm. Sci. 17(2): 243-250, 2018 (December)

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“…To re-establish the integrity of a damaged tissue, an orderly intricate process which involve progression of events called wound healing is initiated by the damaged tissue itself from the moment an injury occurs [ 2 , 3 ]. Wound healing process involves complex mechanisms which involves hemostasis, inflammation, proliferation, and remodeling [ 1 , 4 , 5 ]. In each of these mechanisms, different biochemical substances are recruited to enhance the healing process.…”

Section: Introductionmentioning

confidence: 99%

“…Expression of matrix metalloproteinases promotes remodeling of the extracellular matrix [ 11 ]. Overall, measurable phenomena involved in wound healing include: Wound contraction, epithelialization, and granulation tissue formation [ 5 ]. The contributions to wound healing by these phenomena depend on the type of wound.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of wound healing potential of methanolic Crinum jagus bulb extract

Udegbunam¹,

Kene²,

Anika³

et al. 2015

J Intercult Ethnopharmacol

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Objective:Crinum jagus (J. Thomps.) Dandy commonly called Harmattan or St. Christopher’s lily belonging to the family Liliaceae is widely used traditionally in Southeastern Nigeria for treatment of skin sores. This study investigated the wound healing potentials of methanolic C. jagus bulb extract (MCJBE) using incision, excision, and dead space wound healing models.Materials and Methods:Phytochemical screening showed the presence of alkaloids, glycosides, tannins, saponins in the extract, but absence of flavonoids. In the incision and dead space wound models, rats were dosed orally with 300 mg/kg body weight (bw) of 10 and 5% of MCJBE solution, respectively, while in the excision wound model, rats were treated topically with 10 and 5% MCJBE ointments (MCJBEO), respectively.Result:The 10% MCJBE gave significantly (P < 0.05) highest percentage rate of wound contraction, shortest re-epithelialization and complete healing time when compared with 5% MCJBE and reference drug, framycetin sulfate. The extract of C. jagus showed significant (P < 0.05) concentration-dependent wound healing activity in incision, dead space and excision wound models. No contaminating microbial organism was isolated from wound sites of the rats dosed and treated with MCJBE throughout the study period. At day 7, post infliction of excision wound, histomorphological, and histochemical studies revealed more fibroblasts and Type 1 collagen deposits in wound site sections of rats treated with both 10 and 5% MCJBEO while those of the control showed more inflammatory cells and fewer Type 1 collagen deposits. At day 14 post infliction of excision wound, more epithelial regeneration with overlying keratin were seen in the histological sections of wounds of rats treated with both 10 and 5% MCJBEO, while histochemical study showed more Type 1 collagen deposits in wound site sections of rats in 10% MCJBEO treated group.Conclusion:This study established that methanolic C. jagus bulb extract potentiates wound healing. The study thus validated the folkloric use of C. jagus bulb in the management of skin sores and boils.

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Evaluation of the antioxidant activity and the healing action of the ethanol extract of Calotropis procera bark against surgical wounds

Cited by 32 publications

References 17 publications

Natural Compounds for Wound Healing

Natural Compounds for Wound Healing

Acute Toxicity and Hepatotoxicity Evaluation of Methanol Extract of Root Bark of Calotropis gigantea in Rats

Evaluation of wound healing potential of methanolic Crinum jagus bulb extract

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