Evaluation of wound healing potential of methanolic Crinum jagus bulb extract

Udegbunam, Sunday Ositadimma; Kene, Raphel Okoli Chukwujekwu; Anika, Silavanus Maduka; Udegbunam, Rita Ijeoma; Nnaji, T. O.; Anyanwu, Madubuike Umunna

doi:10.5455/jice.20150405064050

Cited by 10 publications

(7 citation statements)

References 28 publications

(50 reference statements)

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“…The marc was re-macerated to increase the yield. The three successive filtrates were combined, concentrated by Rota vapor at 40 °C to eliminate the alcoholic solvent, deep-frozen in a refrigerator at -20 °C, dried using drying oven at 40 °C, and stored in a refrigerator till used for the experimental [ 5 ].…”

Section: Methodsmentioning

confidence: 99%

“…Wound which might faced everyone in life time [ 1 ] can be described as “a loss or breaking of cellular, anatomical and/or functional connection of living tissues that result in a breach, contravention or interrupting of tissue integrity [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. These in turn have an important impact on public health care systems and resource expenses [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the wound healing activity of the crude extract of root bark of Brucea antidysentrica, the leaves of Dodonaea angustifolia and Rhamnus prinoides in mice

Tessema

Molla

2021

Heliyon

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Background: Wounds are major problems of developing countries that can be managed alternatively using traditional medicinal plants. Since majority of currently available drugs for wound management are expensive and pose problems such as allergy and drug resistance, it is pivotal for the world to have intensified inquiries on the claimed medicinal plants to come up with wound healing chemicals being affordable, effective and safe. Ethiopian traditional healers recruit a wide range of medicinal plants with wound healing activities. Root bark juice of Brucea antidysentrica, the leaves of Rhamnus prinoides and Dodonaea angustifolia are claimed among others in the folklore medicine. Therefore, the aim of this study was to evaluate the in vivo wound healing activities of the root bark juice of Brucea antidysentrica, the leaves of Rhamnus prinoides and Dodonaea angustifolia in mice. Method: The root bark juice of Brucea antidysentrica, the leaves of Rhamnus prinoides and Dodonaea angustifolia were collected, dried, ground to coarse powders. Then the crude extract was obtained by macerating with 80% methanol. The filtrate was dried, reconstituted in appropriate solvent and the wound healing activity was evaluated using excision and incision wound models. Results: On the last day of treatment, 80% methanol extracts from the selected medicinal plants showed a significant wound healing activity against control as supported by an increase in % wound contraction and a decrease in Epithelialization period. Ten percent of Rhamnus prinoides showed significant wound contraction against the control (P < 0.05) on days 2 and 4. But on day 6; except 5% extracts of Brucea antidysentrica and Rhamnus prinoides; all doses of extracts contracted the wound significantly (P < 0.05). Extracts of Dodonea angustifolia (5% & 10%) and 10% of Rhamnus prinoides and Brucea antidysentrica increases wound contraction rate with increasing significant level on days 8 & 10 (P < 0.01) and 12 &14 (P < 0.001). Among the extracts, 10% of Dodonea angustifolia showed maximum percent (99.9%; P < 0.001) of wound contraction followed by 5% Dodonea angustifolia (99.15%; P < 0.001) and 10% Rhamnus prinoides (99.00%; P < 0.001) on the last day of treatment. In addition; significantly shorter healing time was attained by 5% &10% leaves of Dodonea angustifolia (P < 0.01), 10% leaves Rhamnus prinoides & root barks Brucea antidysentrica (P < 0.05). Ten percent of Rhamnus prinoides & Brucea antidysentrica (P < 0.05) and both doses (5% & 10%) of Dodonea angustifolia (P < 0.01) significantly increased the tensile strength by 54.10%, 56.58%, 63.04%, and 79.19%, respectively against the control. Conclusion: The 80% methanol crude extracts of the study plants support the traditional claims for healing of wounds as evidenced by an increase in wound contraction rate and tensile strength, decrease in Epithelialization period.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the wound healing activity of the crude extract of root bark of Brucea antidysentrica, the leaves of Dodonaea angustifolia and Rhamnus prinoides in mice

Tessema

Molla

2021

Heliyon

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“…Crinum jagus belonging to Lilliaceae family, is a tender perennial bulb with tulip-like (showy) white flowers and called Bush onions, and it's found in tropical and subtropical areas all over the world (Udegbunam et al, 2015).…”

Section: Crinum Jagusmentioning

confidence: 99%

Phytotherapeutic mechanism of medicinal plants with wound-healing potential: a mini-review

Emmanuel

Adesibikan

Oladeji

2021

Preprint

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The applications of medicinal plant species for diverse therapeutic effects are well documented throughout the world. In recent times, the screening of higher plants for unique biologically active compounds, particularly those with pronounced therapeutic potency, has received the interest of the science community. A wound is a loss or break in the anatomic stability of active tissue. It not only poses a physical and mental threat to zillions of people but could cause the failure of multiple organs, amputation, and even death. Therefore, thousands of plants have been screened to obtain active metabolites or compounds that can accelerate the process of restoring the damaged tissue structure and inhibit the probability of infections. Due to the severity of wounds to the human body, it is essential to explore safe, economical, and environmentally friendly therapeutics from nature. This review aims to conduct a comprehensive search of medicinal herbs to uncover their therapeutic potential, identify gaping holes, and assess future research prospects that could lead to the discovery of novel pharmacophores. Thus, the review is tailored towards the appraisals of phytotherapeutic mechanism and wound healing efficacy of medicinal plants, which will help spur future research and improve our current knowledge leading to the unearthing of novel and potent pharmacophores with pronounced wound healing potentials. Several medicinal plants with scientifically proven wound-healing activities are reported and discussed alongside phytochemicals present their various extracts and isolates. The achievable wound-healing closure rate of each plant was also reported with a focus on what is responsible for the healing rate.

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“…Others are calcium tetrata, 6-hydroxycrinamine and calcium oxalate [6]. The ethanol extract of C. jagus was shown to have antidiabetic, antioxidant and antimicrobial effects [6].…”

Section: Introductionmentioning

confidence: 99%

“…Others are calcium tetrata, 6-hydroxycrinamine and calcium oxalate [6]. The ethanol extract of C. jagus was shown to have antidiabetic, antioxidant and antimicrobial effects [6]. Despite the great potential of Crinum species as a valuable source of bioactive compounds, no scientific data regarding the chemical composition and biological potential of essential oil from C. jagus has been reported.…”

Section: Introductionmentioning

confidence: 99%

Variation in pre-extraction processes influences the differences in chemical constituent, quantity and biochemical activities of volatile oils from Crinum jagus (Th.) D.: Gas Chromatography-Mass Spectrometry analysis

Oladimeji

2018

Journal of Taibah University for Science

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A comparative study performed on essential oil composition, cytotoxic and antioxidant activities of fresh and dried samples involving leaf and bulb of Crinum jagus (Th.) D. were reported. Qualitative and quantitative variations in the composition of oils were investigated using GC and GC-MS. The oil extracted from the leaf of C. jagus's was characterized by high proportions of beta-ocimene (10.0-13.8%), followed by hexadecane (2.6-11.1%), tetramethylpentadecane (9.3-10.4%) and phytol (7.0-9.0%). Bulb oil is rich in 14-methylpentanedecanoic acid methyl ester (20.6-22.5%), tetratetracontane (7.9-10.0%) and 9,12-octadecadinenoic acid (14.0-14.2%). Dried leaves and dried bulbs exhibited the highest cytotoxic activity (IC50 of 0.002 and 0.003 µg/mL, respectively) followed by fresh leaves 0.033 µg/mL and fresh bulb 0.55 µg/mL. The essential oils at 1.0 mg/mL displayed significant antioxidant activities. The level of antioxidant capacity varied according to samples. The chemical constituents and quantities significantly varied based on sample pre-extraction processing, thus affecting the biochemical activities.

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Evaluation of wound healing potential of methanolic Crinum jagus bulb extract

Cited by 10 publications

References 28 publications

Evaluation of the wound healing activity of the crude extract of root bark of Brucea antidysentrica, the leaves of Dodonaea angustifolia and Rhamnus prinoides in mice

Evaluation of the wound healing activity of the crude extract of root bark of Brucea antidysentrica, the leaves of Dodonaea angustifolia and Rhamnus prinoides in mice

Phytotherapeutic mechanism of medicinal plants with wound-healing potential: a mini-review

Variation in pre-extraction processes influences the differences in chemical constituent, quantity and biochemical activities of volatile oils from Crinum jagus (Th.) D.: Gas Chromatography-Mass Spectrometry analysis

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