Evaluation of the Antihyperlipidemic and Antioxidant Effects of Catharanthus roseus Extracted from Vinca minor in Diabetic Rats

Abstract

The role of oxidative stress is known among the patients of diabetes as the level of reactive oxygen species was high among diabetic patients. This oxidative stress is generated in diabetic patients due to continuous high glucose levels that cause to decrease in the defence mechanism for antioxidant enzymes within the body. The reduction of the antioxidant defence mechanism leads towards the generation of hydroxyl radicals consequently results in lipid peroxidation. The objective of this study is to examine the efficacy of Vincamine extracts as antihyperlipidemic and antioxidant in diabetic rats. To evaluate the antihyperlipidemic and antioxidant effects of Vincamine, adult BB Wistar rats, weighing 150- 170 g were obtained and divided in six groups. Blood analysis was taken measure the observed parameters. The findings showed vincamine display antioxidant, hypoglycaemic and hypolipidemic activity.It is concluded that vincamine hasa protective role and acts as a good antioxidant activity along with effective antidiabetic effects.

Natural remedies for hyperlipidemia: A review

“…Part Used: Rhizome protodioscin Most probably it is known to act as a HMG-CoA reductase inhibitor [71] 49. Vinca Scientific name: Catharanthus roseus Family: Apocynaceae Part Used: leaves Vincamine Reduced the oxidative stress and Reactive oxygen species [72] . Activation of PPARa stops the formation of macrophage foam cells formation of reactive oxygen species (ROS), and associated lipoprotein oxidative modification.…”

Effects of vindoline on rat cytochrome P450 isoform activities in vitro

“…The plant is known to produce more than 200 important compounds (mainly alkaloids) (Chaudhary et al, 2015; Gupta et al, 2005). In some countries, hot water decoctions of the leaves are used for diabetic treatment (Aboelnaga, 2021; Yao et al, 2013). Previous reports revealed that the alcoholic extract of the leaves of C. roseus exhibited blood glucose‐lowering activity (Chattopadhyay, 1999).…”