Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study

Abstract

Background: Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that still present many side effects, are the cause for this problem. These limitations emphasize the need to develop new and more effective antifungal agents with lesser side effects. Materials and Methods: The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of Curcuma longa on four dilutions of Candida albicans (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium. Results: There was complete inhibition of the growth of all four dilutions of Candida at a concentration of 800 μl which is considered as the MIC of alcoholic extract of turmeric on C. albicans , and the minimum fungicidal concentration was at 1600 μl. Conclusion: This study indicates a potent antifungal action of C. longa against C. albicans .

Antifungal activities of the rhizome extract of five member Zingiberaceae against Candida albicans and Trichophyton rubrum

“…The extract showed antifungal activity against C. albicans in the agar well diffusion assay (10.2-27.1 mm inhibition diameter) and against T. rubrum (27.3-44.3 mm inhibition diameter). These results are in accordance with (Murugesh et al (2019) wherethey studied potent antifungal action of C. longa (alcoholic extract) against C. albicans. A. galanga has antifungal activity against filamentous fungi (Handajani and Purwoko 2008), Z. officinale (ginger) had pronounced antifungal activity, including strains that were highly resistant to amphotericin B and ketoconazole (Ficker et al 2003).…”

Curcumin: Natural Antimicrobial and Anti Inflammatory Agent

“…So far, phytochemicals have remained the leading source for potential antimicrobial agents, whether investigated independently or in a combination with another substance [2,25]. Recent studies have demonstrated a wide range of antimicrobial properties of curcumin mediated by different mechanisms, such as alteration of gene expression, inhibition of bacterial DNA replication and disruption of the bacterial cell membrane [26][27][28].Literature data demonstrate the beneficial and preventive role of curcumin against various microorganisms [29][30][31]. Despite various studies evaluating the antimicrobial activity of curcumin, further research is required with different concentrations against different strains of microorganisms.…”

Biomedical Effects of Popular Phytonutrients and Their Phytochemicals: A Comprehensive Review

“…From this study, phytochemicals in turmeric have better antifungal activity working in combination than individual compounds [78]. Murugesh and colleagues elucidated that turmeric extracts exhibit a potent anticandidal effect against Candida albicans on in vitro studies [79]. In a randomized clinical trial, researchers demonstrated that the topical administration of curcumin 5% ointment can significantly reduce knee pain in osteoarthritis patients [80].…”