Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate

Noor, Neveen A.; Ezz, Heba S. Aboul; Faraag, Abdel Razik; Khadrawy, Yasser A.

doi:10.1016/j.yebeh.2012.03.026

Cited by 41 publications

(25 citation statements)

References 86 publications

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“…Although bioavailability of compounds like curcumin is lower when orally administered as compared to intraperitoneal route, most previous studies have administered curcumin orally (Agarwal et al, 2011;Ezz et al, 2011;Noor et al, 2012;Reeta et al, 2011). In addition, there are some reports that in vivo curcumin could cross the blood-brain barrier in sufficient amount to exert a direct neuroprotective effect in the brain (Garcia-Alloza et al, 2007;Yang et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy

Kiasalari

Roghani

Khalili

et al. 2013

Pharmaceutical Biology

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Context: Temporal lobe epilepsy (TLE) is an intractable neurological disorder. Curcumin is the bioactive component of turmeric with anti-epileptic and neuroprotective potential. Objective: The beneficial effect of curcumin on the intrahippocampal kainate-induced model of TLE was investigated. Materials and methods: Rats were divided into sham, curcumin-pretreated sham, kainate and curcumin-pretreated kainate groups. The rat model of TLE was induced by unilateral intrahippocampal injection of 4 mg of kainate. Rats received curcumin p.o. at a dose of 100 mg/kg/d starting 1 week before the surgery. Seizure activity (SE) and oxidative stressrelated markers were measured. Furthermore, the Timm index for evaluation of mossy fiber sprouting (MFS) and number of Nissl-stained neurons were quantified. Results: All rats in the kainate group had SE, while 28.5% of rats showed seizures in the curcumin-pretreated kainate group. Malondialdehyde and nitrite and nitrate levels significantly increased in the kainate group (p50.01 and p50.05, respectively), and curcumin significantly lowered these parameters (p50.05). Superoxide dismutase activity significantly decreased in the kainate group (p50.05) and curcumin did not improve it. Rats in the kainate group showed a significant reduction of neurons in Cornu Ammonis 1 (CA1) (p50.05), CA3 (p50.005) and hilar (p50.01) regions, and curcumin significantly prevented these changes (p50.05-0.005). The Timm index significantly increased in the kainate group (p50.005), and curcumin significantly lowered this index (p50.01). Discussion and conclusion: Curcumin pretreatment can attenuate seizures, lower some oxidative stress markers, and prevent hippocampal neuronal loss and MFS in the kainate-induced model of TLE.

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Section: Discussionmentioning

confidence: 99%

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy

Kiasalari

Roghani

Khalili

et al. 2013

Pharmaceutical Biology

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“…In the cortex, a significant increase in aspartate, glutamate, GABA, glycine, and taurine levels was obtained after pilocarpine injection. Treatment of pilocarpinized rats with curcumin and valproate ameliorated most of the changes in amino acid concentrations and reduced the histopathological abnormalities induced by pilocarpine, while N. sativa oil failed to improve the pilocarpine-induced abnormalities [111] .…”

Section: Anticonvulsant Activitymentioning

confidence: 93%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,092

796

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“…Nigella sativa (NS), usually known as black cumin, belongs to the botanical family of Ranunculaceae which is extensively farmed in the Mediterranean region (Noor et al, 2012). NS has been widely carried out researches for its biological activities and restorative potential and illustrated to have a wide range of activities such as diuretic, antihypertensive, anti-diabetic, anti-cancer, immune-modulatory, antimicrobial, anthelmintic, spasmolytic, bronchodilator, anti-inflammatory, antitussive, gastroprotective, hepato-protective, neuroprotective, renal protective and anti-oxidant properties.…”

Section: ]mentioning

confidence: 99%

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

Safwat

Hussein

Samy

2017

IJB

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Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa oil (NSO) extract on the neurotoxic and hepatotoxic potentials from valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study's case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the enzymatic antioxidant, brain and liver catalase (CAT) activity and the non-enzymatic antioxidant, brain and liver glutathione (GSH) and lipid peroxidation (LPO) concentrations.

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Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate

Cited by 41 publications

References 86 publications

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy

A review on therapeutic potential of Nigella sativa: A miracle herb

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

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