Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test

Pathophysiological Roles of Serotonergic System in Regulating Extrapyramidal Motor Functions

“…1,[3][4][5] Several studies demonstrated that activation of 5-HT 1A receptors improves antipsychotic-induced EPS and motor disabilities in animal models of Parkinson's disease. [10][11][12][13][14][15][16] In our studies, 5-HT 1A agonists (e.g., 8-hydroxy-2-(di-n-propylamino)-tetralin and tandospirone) ameliorated haloperidol-induced bradykinesia and catalepsy with potencies similar to those of antiparkisonian agents (e.g., trihexyphenidyl and L-3,4-dihydroxyphenylalanine (L-DOPA)). 13,14) Consistently with these anti-EPS actions, 5-HT 1A agonists reversed striatal Fos protein expression induced by haloperidol, indicating that 5-HT 1A receptors counteract D 2 receptor blockade by antipsychotics in the striatum.…”

“…[10][11][12][13][14][15][16] In our studies, 5-HT 1A agonists (e.g., 8-hydroxy-2-(di-n-propylamino)-tetralin and tandospirone) ameliorated haloperidol-induced bradykinesia and catalepsy with potencies similar to those of antiparkisonian agents (e.g., trihexyphenidyl and L-3,4-dihydroxyphenylalanine (L-DOPA)). 13,14) Consistently with these anti-EPS actions, 5-HT 1A agonists reversed striatal Fos protein expression induced by haloperidol, indicating that 5-HT 1A receptors counteract D 2 receptor blockade by antipsychotics in the striatum. 14,15) Earlier studies showed that microinjection of 5-HT 1A agonists into the raphe nuclei attenuated antipsychotic-induced catalepsy, suggesting that activation of presynaptic 5-HT 1A autoreceptors can reduce EPS 11) ( Fig.…”

“…1 and Table 1). On the 10,12,13) In addition, it is known that local microinjection of 5-HT 1A agonists into the striatum or cerebral cortex (i.e., motor cortex) attenuates extrapyramidal disorders 16) (Fig. 1 and Table 1).…”

Effects of Tandospirone, a 5-HT1A Agonistic Anxiolytic Agent, on Haloperidol-Induced Catalepsy and Forebrain Fos Expression in Mice

“…It is therefore conceivable that, besides 5-HT 2A antagonism, 5-HT 1A agonism also alleviates APDinduced EPS and/or Parkinson's disease (3). Although the mechanisms for these actions of 5-HT 1A agonists are yet to be clarified, we have previously shown that alleviation of haloperidol-induced EPS by 8-OH-DPAT was resistant against the serotonergic denervation with p-chlorophenylalanine (a 5-HT synthetase inhibitor) (8). Consistent with previous findings (4,7,9), our results suggest that 8-OH-DPAT alleviates APD-induced EPS probably through activating postsynaptic 5-HT 1A receptors (including heteroreceptors).…”

Deficits in Striatal Dopamine and Hippocampal Serotonin Following Induction of Anxiety/Depressive-Like Behaviors by Bisphenol A

“…Several lines of evidence have shown that 5-HT1A receptors play an important role in controlling motor functions and ameliorate various extrapyramidal disorders such as PD (5)(6)(7)(8)(9) and L-DOPA-induced motor disabilities (10)(11)(12)(13). In addition, 5-HT1A receptors are implicated in the pathogenesis and treatment of mood disorders (anxiety/ depression) (8).…”