Evaluation of the antibacterial efficacy of different bioactive lining and pulp capping agents

Abstract

Aim: To evaluate the antibacterial potential of dental cements on the growth of the colonies of Streptococcus mutans. Materials & methods: Ten Discs were prepared from three types of bioactive materials; light cure calcium hydroxide, light cure resin modified glass ionomer, and Biodentine. Bacterial Strain S. mutans was suspended in Tryptone Soy Broth (TS) medium and incubated for 18 h. Agar diffusion test was used to evaluate the antibacterial activity by measuring the gauge of inhibition zone around the discs. Statistical analysis was performed by using one-way Anova test and differences were considered significant at the 95% confidence level (P < 0.05). Results: A significant difference of antibacterial characteristics between groups at p 0.001. Biodentin had the largest inhibition zone (15.14 ± 0.34), followed by Resin modified glass ionomer (11.22 ± 0.13). Light cured Calcium hydroxide showed the smallest inhibition zone (9.15 ± 0.3). Conclusion: While Biodentin showed the strongest antibacterial properties, the VLC bioactive glass ionomer and calcium hydroxide cements are also effective as standard pulp-capping products in inhibiting the growth of S. mutans organism commonly found at the base of a cavity preparation.

The effect of desiccation on water sorption, solubility and hygroscopic volumetric expansion of dentine replacement materials

“…Although the practice of dentin replacement using the 'liner' or 'base' approach may have negative tendency to affect the restoration longevity as has been shown by a recent systematic review [19], it may be legitimate to apply BD as a dentin replacement material compared to other materials mainly due to its effect on preserving the pulp vitality through its bioactive therapeutic effect. Furthermore, it has an antibacterial effect that makes it suitable for deep caries cavities [20] as well as an excellent bond and seal with dentine, short setting time, and good mechanical properties [21]. On the other hand, it does not have a satisfactory wear resistance, mechanical strength and aesthetic to be a definitive restoration.…”

Characterization of Chlorhexidine-Loaded Calcium-Hydroxide Microparticles as a Potential Dental Pulp-Capping Material

“…The antibacterial activity of pulp-capping agents has been widely evaluated with the agar-diffusion test [ 53 , 54 ]. Studies have attested to the diminished efficacy of CHX and Ca(OH) 2 combination in eliminating the bacterial activity [ 55 ], as supported by current findings ( Table 2 ).…”

Oroactive dental biomaterials and their use in endodontic therapy

“…63 Zayed et al evaluated the antibacterial efficacy of calcium hydroxide based-, resin-modified glass ionomer based-, and calcium silicatebased pulp capping materials. 64 The authors observed the largest inhibition zone (in agar studies) with the calcium silicate material. In addition, Zhang et al demonstrated a greater odontogenic potential in bioceramics where a more predictable odontoblast-related gene expression with superior mineralization capability to that of MTA was proven.…”

“…Albeit, even with this change, there is no significant improvement in cytotoxicity between these materials . Zayed et al evaluated the antibacterial efficacy of calcium hydroxide based‐, resin‐modified glass ionomer based‐, and calcium silicate‐based pulp capping materials . The authors observed the largest inhibition zone (in agar studies) with the calcium silicate material.…”