Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus

Getie, Melkamu; Gebre‐Mariam, Tsige; Rietz, R.; Höhne, C; Huschka, C.; Schmidtke, Michaela; Abate, Aida; Neubert, Reinhard H.H.

doi:10.1016/s0367-326x(02)00315-5

Cited by 141 publications

(124 citation statements)

References 16 publications

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“…Some studies have been reported on biological properties of this plant. Antimicrobial activities of this plant has previously been demonstrated on Salmonella typhymurium, Listeria monocytogens, Escherichia coli and Staphylococcus saprophiticus [24] an against streptococcus pyogenes, S. aureus, Coxsackie virus B3 and Influenza A virus [25]. Our results are slightly different from those of [24], but this difference in susceptibility could be attributed to the inherent resistance factors of the test organisms [26], the strains we used were by demonstrated to be multidrug resistant (see table V above).…”

Section: Cussonia Arborea (Ca) Dissotis Longipetala (Dl Lonchocarpuscontrasting

confidence: 56%

Antimicrobial Activities of Some Medicinal Plants Against Multiresistants Microorganisms Causing Urogenital Tract Infections in Cameroon

Merveille¹

2017

JDMP

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Abstract:Urogenital tract infections remain a serious global treat especially in women. The control of these infections is increasingly complicated due to development of resistance against available drugs. Therefore a perpetual search of new antimicrobial molecules is needed to face the challenge of microbial resistance. This study was initiated to screen the antimicrobial activities of methanol extracts of nine Cameroonian medicinal plants, used for the treatment of infectious diseases, against multiresistant pathogens isolated from urogenital infected patients. The plants included: Cussonia arborea, Dissotis longipetala, Lonchocarpus sepium, Nauclea pobeguinii, Picralima nitida, Rumex abyssinicus, Rumex berqueatii, Sapium ellypticum, Psorospermum febrifigum, They were tested on seven strains including six clinical isolates (Escherichia coli, Proteus vulgaris, Providencia stuartii, Pseudomonas aeruginosa, Staphylococcus saprophiticus, Candida krusei) and one reference strain (E. coli JM109). Clinical strains were checked for their multiresistance using disc diffusion method. The antimicrobial activities were determined by agar well diffusion method. MICs were determined using microdilution assay. The phytochemical screening of plants was also done. All the bacteria strains were found to be multidrug-resistant (MDR) against at least 7 of the 12 antibiotics tested. Antimicrobial activities demonstrated that 6/9 (SE, DL, RA, RB, PN, LS) plants were active on at least six microorganisms. MICs ranged from 0.125 to 128mg/ml for crude extracts, from 0.5 to 0.16µg/ml for gentamicin and was 0,002mg/ml for fluconazole. One extract (NP) which showed limited results on agar, inhibited the growth of all the strains with MICs ranging from 1to 16mg/ml showing a limited activity of this extract on agar. We found that four extracts (SE, NP, RA, DL) have significant activities since they presented MICs ≤ 8mg/ml on at least 5 tested microorganism individually. Findings from phytochemical screening showed that most active extracts contain tannins, alkaloids and saponins which could be responsible of these activities.

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Section: Cussonia Arborea (Ca) Dissotis Longipetala (Dl Lonchocarpuscontrasting

confidence: 56%

Antimicrobial Activities of Some Medicinal Plants Against Multiresistants Microorganisms Causing Urogenital Tract Infections in Cameroon

Merveille¹

2017

JDMP

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“…(Polygonaceae) and Rumex abyssinicus Jacq. (Polygonaceae) (Getie et al, 2003) and Mallotus peltatus (Geist) Muell. Arg.…”

Section: Introductionunclassified

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

Agyare

Koffuor

Boakye

et al. 2013

Pharmaceutical Biology

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“…D. viscosa has been used in folk medicine in various cultures of the world. The traditional antimicrobial uses include application as antibacterial, antiviral (Getie et al, 2003;Wagner et al, 1987), and anticandidal agents (Patel and Coogan, 2008). Phytochemical reports describe the presence of phenolics, terpenoids, and saponins (Rojas et al, 1992;Wagner et al, 1987;Sachdev and Kulshreshtha, 1986) in it.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae)

Khurram¹,

Hameed²,

Amin³

et al. 2011

Afr. J. Pharm. Pharmacol.

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The activity of fractions derived from hydroalcoholic extract of Dodonaea viscosa leaves against Candida albicans (Cl. I. 4043) was evaluated. The hydroalcoholic extract was sequentially fractionated to give n-hexane, dichloromethane, ethylacetate and n-butanol fractions that were subjected to qualitative phytochemical analyses. Disk diffusion assay was used in preliminary anticandidal screening with clotrimazole and chloroform serving as positive and negative controls, respectively. Optimized solvent systems were used for thin layer chromatography (TLC) that was followed by contact bioautography to evaluate the bioactivities of the fractions. Using broth microdilution technique, minimum inhibitory concentrations (MIC) of the individual fractions were established. With the exception of aqueous fraction all the fractions exhibited anticandidal activities (zone of inhibition 10 mm) in preliminary screening against test yeast. However, n-hexane fraction showed two inhibition zones at R f = 0.14 and 0.60 in contact bioautography, which indicates location of inhibitory compounds. The MIC of 62.5 µg/ml also supports the presence of anticandidal moieties in n-hexane fraction. Flavonoids, terpenoids, tannins and steroids were the main metabolites indicated in phytochemical screenings.

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Evaluation of the anti-microbial and anti-inflammatory activities of the medicinal plants Dodonaea viscosa, Rumex nervosus and Rumex abyssinicus

Cited by 141 publications

References 16 publications

Antimicrobial Activities of Some Medicinal Plants Against Multiresistants Microorganisms Causing Urogenital Tract Infections in Cameroon

Antimicrobial Activities of Some Medicinal Plants Against Multiresistants Microorganisms Causing Urogenital Tract Infections in Cameroon

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae)

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