Evaluation of the anti‐aging and antioxidant action of Ananas sativa and Moringa oleifera in a fruit fly model organism

Abstract

aging is an inevitable biological complex process. It involves the gradual loss of cellular vitality due to accumulative damage to cellular macromolecules by reactive oxygen species (ROS). These ROS are highly implicated in health, disease, and lifespan. The biochemical pathways involved in the aging process are highly influenced by both exogenous (environmental factors) and endogenous stress factors. These cellular processes are the same in most organisms including the fruit fly, nematode, yeast, mammalian cell line, and rodents. These model organisms have been extensively used in the screening of potent antioxidant botanicals for anti-aging bioactivity. Moringa oleifera and Ananas sativa are great sources of health-promoting nutrients and antioxidants, however, their anti-aging impact is still an evolving area of research interest. Therefore, this review focused on their anti-aging mode of action and some other anti-aging nutriceuticals in different model organisms including the fruit fly. Practical applications Staying forever young and healthy is everyone's right. Aside from genetic trait, healthy feeding is peculiar to the world's longest-living people. Ananas sativa (pineapple) and Moringa oleifera leaves are highly valued fruit and herb with nourishing, antioxidant, and medicinal properties. Their extract exhibit antioxidant, anticancer, anti-inflammatory, and anti-aging activities. The ancient Greeks, Egyptians, and Romans used Moringa seed oil for cosmetics and perfumes. Moringa tea leaves is consumed for its nutritive and medicinal value. Its antioxidant potency endorses its use for anti-aging and other health-promoting purposes. The bioactive compound in pineapple, bromelain, promotes wound healing and it is a component of postsurgical applications due to its anti-inflammatory property. Consumption of Ananas fruit provides the recommended daily allowance of vitamin C, a potent antioxidant. To identify new antiaging bioactive compounds of therapeutic importance, and understanding the mode of action of these nutriceuticals will contribute to new anti-aging research prospects.

Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets

“…In the meantime, a large number of studies indicated that M. oleifera also possessed anti-aging properties. For instance, M. oleifera leaf extracts displayed anti-aging activity by improving oxidative stress resistance and nutrient-sensing pathways ( 10 ), extending the life span, and improving stress tolerance of Caenorhabditis elegans ( 11 ). Moreover, it was also found that the M. oleifera leaf extracts observably decreased age-related neurodegeneration in the old treated rat model ( 12 ), and its cream restored skin vitality and reduced skin aging ( 13 ).…”

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

“…Moringa oleifera is one of the natural compounds that contain many active constituents including flavonoids, alkaloids, glycosides, lipids, proteins, carbohydrates, minerals, and vitamins among others [ 45 , 46 ] and belongs to the family of Moringaceae that are distributed widely in many African and Asian countries [ 47 ]. It has been reported to have antioxidative, anti-inflammatory, antimicrobial, bactericidal, hypoglycemic, anti-cancer, anti-aging, and neuroprotective potentials [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. In the field of AD, MO was reported to exert anti-aging, antioxidative, anti-cholinesterase, and neuroprotective activities [ 27 , 49 , 56 , 57 , 58 ] and is safe at higher doses in both rats and mice as its LD50 was more than 6400 mg/kg in mice [ 59 , 60 , 61 ].…”

“…It has been reported to have antioxidative, anti-inflammatory, antimicrobial, bactericidal, hypoglycemic, anti-cancer, anti-aging, and neuroprotective potentials [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. In the field of AD, MO was reported to exert anti-aging, antioxidative, anti-cholinesterase, and neuroprotective activities [ 27 , 49 , 56 , 57 , 58 ] and is safe at higher doses in both rats and mice as its LD50 was more than 6400 mg/kg in mice [ 59 , 60 , 61 ]. Moreover, in our previous study [ 21 ], we found that MO can alleviate homocysteine-induced AD-like pathological changes including Aβ production, Tau hyperphosphorylation, and neurodegeneration via decreasing BACE1, GSK-3β, CDK5, CaMKII, increasing PP2A activities, and improving oxidative stress and cognitive deficits.…”

Hawthorn extract inhibited the PI3k /Akt pathway to prolong the lifespan of Drosophila melanogaster

“…Aging is thought to be an inevitable biological process, which leads to various diseases including the loss of reproduction and regeneration (Ajagun‐Ogunleye & Ebuehi, 2020). Many studies have shown that ROS are concerned with major processes related to aging, like telomere shortening and autophagy (Lennicke & Cocheme, 2020).…”