Evaluation of the Angiographic Grading Scale in Aneurysms Treated with the WEB Device in 80 Rabbits: Correlation with Histologic Evaluation

Abstract

BACKGROUND AND PURPOSE:The WEB Occlusion Score has been proposed to assess angiographic outcomes for intracranial aneurysms treated with the Woven EndoBridge (WEB) device. Using a large series of experimental aneurysms treated with the WEB, we had the following objectives: 1) to compare angiographic outcomes as measured by the WEB Occlusion Scale with histologic results, and 2) to assess interobserver and intraobserver agreement of the WEB Occlusion Scale.

How to WEB: a practical review of methodology for the use of the Woven EndoBridge

“…It is important to differentiate the filling of proximal marker recess from residual filling of the aneurysm neck. Studies have shown that this proximal marker recess is covered by dense neoendothelium after aneurysm occlusion with the WEB device 19. Thus, the filling of this marker recess area with contrast is an expected finding in completely occluded aneurysms with the WEB device 7.…”

Occlusion assessment of intracranial aneurysms treated with the WEB device

“…Fiorella et al [8] reported kappa = 0.78, and in their animal study Rouchaud et al [17] reported kappa = 0.63.…”

Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device

“…The WEB occlusion scale was approved and validated as the grading scale for the 150 patients in the US WEB-IT Clinical Study and was correlated to histology in an 80-subject preclinical study. 39,40 Our study has several limitations. First, a small number of patients were included.…”