Evaluation of the anesthetic effect of nasal mucosa with tetracaine 0.5% on hemodynamic changes and postoperative pain of septoplasty: A randomized controlled trial

Abstract

The nasal septum repair surgery is the dangerous operations that any stimulation of this area causes a large change in the rhythm of the heartbeat and blood pressure. This study aimed to determine the effects of tetracaine 0.5% on changes in heartbeat and heart rhythm, hemodynamic changes during surgery, intraoperative bleeding, and pain after septoplasty surgery. The irregular double-blind clinical trial registry of clinical trials Iran with the code number (IRCT: 20150526625N8) in the first half of 2013 on 86 patients in Kashani hospital of Shahrekord. Having selected and matched the patients were divided into two groups. Case group was dropped tetracaine 0.5% in each of the nasal cavity 15 min before the beginning of the operation. The control group was dropped distilled water 15 min preoperation in each of the nasal cavity. The surgery lasted about 30–60 min. Clinical symptoms were evaluated after anesthetic induction as well as pain using the visual analog scale after the operation, in the recovery room. The collected data were analyzed using SPSS version software 17 through independent t-test, Chi-square, and repeated measures variance analysis. Postoperative pain intensity in the experimental group compared to the control group was significantly lower than the control group (P < 0.05); however, blood pressure and heart rate during anesthesia, there was no difference between groups (P > 0.05). Based on the findings, intake of tetracaine drop 0.5% has no impact on some hemodynamic changes during septoplasty operation. However, compared with the control group, pain was significantly reduced.

Delayed-Onset Neuropathic Pain after Septoplasty

“…Nasal pain after septoplasty and septorhinoplasty is expected acutely, and numerous studies have been conducted looking into the optimum analgesia to manage short-term pain [ 4 – 6 ]. However, the length of postoperative pain is usually a few days rather than months or years.…”

Biopolymer‐based Carriers for DNA Vaccine Design

“…PEG has been shown to prevent particle interaction and increase their circulation time in blood, thus enhancing the probability of reaching the targeted tissue. PEG surface modification has been demonstrated for PLGA‐, [98] PDA‐, [185] gelatine‐, [186, 187] polyspermine‐, [141] and PLA‐based [188] DNA carriers.…”

“…[183,184] To prevent aggregation, asurface coating with hydrophilic polymers,s uch as polyethylene glycol (PEG), can be introduced to the nanoformulation. PEG has been shown to prevent particle interaction and increase their circulation time in blood, thus enhancing the probability of reaching the targeted tissue.P EG surface modification has been demonstrated for PLGA-, [98] PDA-, [185] gelatine-, [186,187] polyspermine-, [141] and PLA-based [188] DNAc arriers.…”

Comparison of the effects of articaine, tetracaine, and lidocaine application on pain and hemorrhage during and after nasal pack removal

“…The effect of tetracaine is fast-acting, long term, having low risk of methemoglobinemia, and strong compared to other local anesthetics. The mean dose is 0.1-0.2 mg/ kg, and the mean effect duration is 90-200 min 7 .…”