Evaluation of the acceptability of a new oral vitamin K prophylaxis for breastfed infants

Strehle, EM; Howey, C; Jones, Rebecca

doi:10.1111/j.1651-2227.2009.01630.x

Cited by 11 publications

(4 citation statements)

References 27 publications

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“…15 The association between intramuscular vitamin K refusal by parents and midwife-assisted deliveries was replicated by investigators in Michigan. 6 In a cross-sectional survey of mothers in the United States, investigators found that Regimens reported in European studies included 3-dose series of oral vitamin K (given at birth, either day 4 or week 1, and week 4), 61,63 multiple-dose series (at birth and then either daily or weekly until 3 months of age), 62,65 2-dose series (at birth and day 4), 66 and 4-dose series (at birth and at weeks 2, 4, and 6 [in breastfed neonates]). 64 The incidence of VKDB after oral vitamin K prophylaxis in these studies was up to 2.8 per 100 000.…”

Section: Concern Of Harm From the Injectionmentioning

confidence: 99%

Refusal of Intramuscular Vitamin K by Parents of Newborns: A Review

Loyal

Shapiro

2020

Hospital Pediatrics

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In 2019, the American Academy of Pediatrics made public education about intramuscular vitamin K administration at birth a public health priority, partly in response to reports of refusal of intramuscular vitamin K by parents of newborns that led to vitamin K deficiency bleeding (VKDB). We reviewed the literature on the frequency of, reported reasons for, and factors associated with refusal of intramuscular vitamin K, incidence of VKDB in newborns who did not receive intramuscular vitamin K, and use of oral vitamin K to prevent VKDB. Without prophylaxis, estimates of the incidence per 100 000 births of VKDB range from 250 to 1700 for early VKDB and from 10.5 to 80 for late VKDB. The frequency of refusal of intramuscular vitamin K by parents ranged from 0% to 3.2% in US hospitals, up to 14.5% in home births, and up to 31.0% in birthing centers. Reported reasons for refusal were concern of harm from the injection, a desire to be natural, and a belief in alternative methods of prophylaxis. Parents who refused intramuscular vitamin K were more likely to refuse immunizations. Many different regimens were used for orally administered vitamin K; it is not clear which is best, but all are less effective than intramuscular vitamin K. VKDB is rare but can result in either neurologic sequelae or death. In addition to continued surveillance of the frequency of both refusal of intramuscular vitamin K and VKDB, a renewed focus on education of and collaboration with parents is needed to address this major public health threat.

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Section: Concern Of Harm From the Injectionmentioning

confidence: 99%

Refusal of Intramuscular Vitamin K by Parents of Newborns: A Review

Loyal

Shapiro

2020

Hospital Pediatrics

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“…Administration of phylloquinone at a pharmacological dose, either orally or by intramuscular injection, is usual practice for prevention of haemorrhagic disease in newborn infants (Clarke et al, 2006;Busfield et al, 2007;Strehle et al, 2010;Mihatsch et al, 2016). Oral pharmacological doses of MK-4 (2 mg at birth, and 4 mg at 1 week of age, n = 72,000) have been successfully used in newborns for prophylaxis of haemorrhagic diseases in Japan (Matsuzaka et al, 1987).…”

Section: Deficiencymentioning

confidence: 99%

Dietary reference values for vitamin K

Turck¹,

Bresson²,

Burlingame³

et al. 2017

EFS2

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for vitamin K. In this Opinion, the Panel considers vitamin K to comprise both phylloquinone and menaquinones. The Panel considers that none of the biomarkers of vitamin K intake or status is suitable by itself to derive DRVs for vitamin K. Several health outcomes possibly associated with vitamin K intake were also considered but data could not be used to establish DRVs. The Panel considers that average requirements and population reference intakes for vitamin K cannot be derived for adults, infants and children, and therefore sets adequate intakes (AIs). The Panel considers that available evidence on occurrence, absorption, function and content in the body or organs of menaquinones is insufficient, and, therefore, sets AIs for phylloquinone only. Having assessed additional evidence available since 1993 in particular related to biomarkers, intake data and the factorial approach, which all are associated with considerable uncertainties, the Panel maintains the reference value proposed by the Scientific Committee for Food (SCF) in 1993. An AI of 1 lg phylloquinone/kg body weight per day is set for all age and sex population groups. Considering the respective reference body weights, AIs for phylloquinone are set at 70 lg/day for all adults including pregnant and lactating women, at 10 lg/day for infants aged 7-11 months, and between 12 lg/day for children aged 1-3 years and 65 lg/day for children aged 15-17 years.

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“…19 Several limitations in this study should be noted. Many expecting parents search for a pediatrician or family practitioner at this stage of pregnancy and seek information from professionals and the media (eg, popular media and the internet) toward the beginning of their role as parents.…”

Section: Discussionmentioning

confidence: 89%