Evaluation of Tear Meniscus Dynamics Using Anterior Segment Swept-Source Optical Coherence Tomography After Topical Solution Instillation for Dry Eye

Akiyama-Fukuda, Reina; Usui, Tomohiro; Yoshida, Tatsuya; Yamagami, Satoru

doi:10.1097/ico.0000000000000807

Cited by 31 publications

(20 citation statements)

References 29 publications

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“…Akiyama‐Fukuda et al. () obtained a longer residence time after 0.3% SH instillation compared with 0.1% SH, remaining significantly until 10 and 3 min, respectively, whose results are similar to those of this present study. Napoli et al.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Carracedo

Pastrana

Serramito

et al. 2018

Acta Ophthalmologica

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Purpose: To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions. Methods: An experimental, double-masked, randomized study was performed. Twenty-three healthy subjects (16 women and seven men; mean age 23.57 AE 2.56 years) participated in this study. About 35 ll of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus measurements (height, depth and turbidity) were taken with OCT at 30 seconds and 1, 3, 5, 10 and 20 min after instillation. Subsequently, the Schirmer test and tear break-up time (TBUT) were evaluated. Results: Tear meniscus depth and tear meniscus height showed a significant increase with all solutions compared to basal values: up to 3 min for 0.1% SH, up to 5 min for 0.2% and up to 10 min for 0.3% SH ophthalmic solution. Tear meniscus turbidity was also increased at 30 seconds for 0.1%, 0.2% and 0.3% SH artificial tears (p < 0.05). This increase remained significant for up to 1 min for 0.2% and 0.3% SH solutions (p < 0.05). After 5 min of saline and 0.1% SH instillation, the turbidity was lower than basal values (p < 0.05). There was a significant increase in the TBUT for all solutions after instillation (p < 0.05). No differences between the Schirmer pre-and postinstillation were found (p > 0.05). Finally, the comfort was significantly improved for all ophthalmic solutions (p < 0.05). Conclusion: Sodium hyaluronate (SH) ophthalmic solutions increase residence time in healthy subjects and are positively correlated with its concentration and therefore the viscosity.

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Section: Discussionsupporting

confidence: 91%

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Carracedo

Pastrana

Serramito

et al. 2018

Acta Ophthalmologica

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“…110 TMH has been shown to correlate with DED and the traditional measurements for DED. 97,110–120 Some studies suggest there is good repeatability and reproducibility of TMH measurements in DED and normals. 101,114,115,118,120–122 However, TMH taken with different machines may not be comparable.…”

Section: Point Of Care Biomarkersmentioning

confidence: 99%

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

Roy

Wei

Kuklinski

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeBiomarkers with minimally invasive and reproducible objective metrics provide the key to future paradigm shifts in understanding of the underlying causes of dry eye disease (DED) and approaches to treatment of DED. We review biomarkers and their validity in providing objective metrics for DED clinical research and patient care.MethodsThe English-language literature in PubMed primarily over the last decade was surveyed for studies related to identification of biomarkers of DED: (1) inflammation, (2) point-of-care, (3) ocular imaging, and (4) genetics. Relevant studies in each group were individually evaluated for (1) methodological and analytical details, (2) data and concordance with other similar studies, and (3) potential to serve as validated biomarkers with objective metrics.ResultsSignificant work has been done to identify biomarkers for DED clinical trials and for patient care. Interstudy variation among studies dealing with the same biomarker type was high. This could be attributed to biologic variations and/or differences in processing, and data analysis. Correlation with other signs and symptoms of DED was not always clear or present.ConclusionsMany of the biomarkers reviewed show the potential to serve as validated and objective metrics for clinical research and patient care in DED. Interstudy variation for a given biomarker emphasizes the need for detailed reporting of study methodology, including information on subject characteristics, quality control, processing, and analysis methods to optimize development of nonsubjective metrics. Biomarker development offers a rich opportunity to significantly move forward clinical research and patient care in DED.OverviewDED is an unmet medical need — a chronic pain syndrome associated with variable vision that affects quality of life, is common with advancing age, interferes with the comfortable use of contact lenses, and can diminish results of eye surgeries, such as cataract extraction, LASIK, and glaucoma procedures. It is a worldwide medical challenge with a prevalence rate ranging from 8% to 50%. Many clinicians and researchers across the globe are searching for better answers to understand the mechanisms related to the development and chronicity of DED. Though there have been many clinical trials for DED, few new treatments have emerged over the last decade. Biomarkers may provide the needed breakthrough to propel our understanding of DED to the next level and the potential to realize our goal of truly personalized medicine based on scientific evidence. Clinical trials and research on DED have suffered from the lack of validated biomarkers and less than objective and reproducible endpoints. Current work on biomarkers has provided the groundwork to move forward. This review highlights primarily ocular biomarkers that have been investigated for use in DED, discusses the methodologic outcomes in providing objective metrics for clinical research, and suggests recommendations for further work.

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“…All three parameters correlated with Schirmer’s test scores, corneal vital staining score and TBUT, with Schirmer’s test score having the strongest correlation, which suggests the OCT tear meniscus parameters likely reflect the tear fluid quantity 27. The increase in TMH, TMA and TMH also varies depending on the instillation of different artificial tears of different retentive properties, which allows quantitative evaluation of the tear fluid dynamics after treatment 28. While Schrimer’s I test is a convenient and low-cost clinical test and acts as a surrogate for tear volume, it has poor reproducibility and is inherently invasive and causes reflex tear secretion.…”

Section: Imaging Techniquesmentioning

confidence: 93%

Advances in dry eye imaging: the present and beyond

et al. 2017

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New advances in imaging allow objective measurements for dry eye as well as define new parameters that cannot be measured by clinical assessment alone. A combination of these modalities provides unprecedented information on the static and dynamic properties of the structural and functional parameters in this multifactorial disease. A literature search was conducted to include studies investigating the use of imaging techniques in dry eye disease. This review describes the application of non-invasive tear breakup time, optical coherence tomography, meibomian gland imaging, interferometry, in vivo confocal microscopy, thermography and optical quality assessment for this condition.

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Evaluation of Tear Meniscus Dynamics Using Anterior Segment Swept-Source Optical Coherence Tomography After Topical Solution Instillation for Dry Eye

Abstract: The instillation of ophthalmic solutions for the treatment of dry eye greatly increased tear meniscus measurements in healthy subjects. Thus, SS-OCT can be a practical tool for the quantitative evaluation of early-phase tear fluid dynamics.

Cited by 31 publications

References 29 publications

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

Advances in dry eye imaging: the present and beyond

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