Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Abstract

Purpose: To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions. Methods: An experimental, double-masked, randomized study was performed. Twenty-three healthy subjects (16 women and seven men; mean age 23.57 AE 2.56 years) participated in this study. About 35 ll of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus measurements (height, depth and turbidity) were taken with OCT at 30 seconds and 1, 3, 5, 10 and 20 min after instillation. Subsequently, the Schirmer test and tear break-up time (TBUT) were evaluated. Results: Tear meniscus depth and tear meniscus height showed a significant increase with all solutions compared to basal values: up to 3 min for 0.1% SH, up to 5 min for 0.2% and up to 10 min for 0.3% SH ophthalmic solution. Tear meniscus turbidity was also increased at 30 seconds for 0.1%, 0.2% and 0.3% SH artificial tears (p < 0.05). This increase remained significant for up to 1 min for 0.2% and 0.3% SH solutions (p < 0.05). After 5 min of saline and 0.1% SH instillation, the turbidity was lower than basal values (p < 0.05). There was a significant increase in the TBUT for all solutions after instillation (p < 0.05). No differences between the Schirmer pre-and postinstillation were found (p > 0.05). Finally, the comfort was significantly improved for all ophthalmic solutions (p < 0.05). Conclusion: Sodium hyaluronate (SH) ophthalmic solutions increase residence time in healthy subjects and are positively correlated with its concentration and therefore the viscosity.

Evaluation of 18 artificial tears based on viscosity and pH

“…Previous work [1][2][3] has suggested that long-term use of artificial tears was proven to revitalise ocular surface integrity; however, short-term effects remain debatable. [4][5][6] Commercially available artificial tear products are unique as their mechanism of action depends on the formulation used by the respective manufacturers. These formulations are not only limited to types of lubrication agents, demulcents, and emollients, but also the addition and selection of preservatives.…”

Anwendungsmöglichkeiten der optischen Kohärenztomographie beim trockenen Auge

“…Analog zur TFT kommt es auch zu einem Anstieg der Tränenmeniskusparameter nach 1-maliger Verabreichung von topischen Lubrikanzien [52][53][54]. Auch scheint sich die Methode gut zur Therapieevaluierung über einen längeren Zeitraum zu eignen, z.…”

Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease

“…In addition, tear meniscus parameters differ between different types of dry eye and may therefore be valuable in differential diagnosis [ 45 ]. Single administration of topical lubricants increases tear meniscus parameters in healthy subjects as well as in patients with OSD and may therefore also be used as a marker for corneal residence time of eye drops [ 46 , 47 , 48 ]. Two-month treatment with topical cyclosporine increased tear meniscus height and volume in patients with dry eye, suggesting that this parameter might also be valuable in therapeutic monitoring [ 13 ].…”