2018
DOI: 10.1111/aos.13887
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Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Abstract: Purpose: To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions. Methods: An experimental, double-masked, randomized study was performed. Twenty-three healthy subjects (16 women and seven men; mean age 23.57 AE 2.56 years) participated in this study. About 35 ll of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus m… Show more

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Cited by 31 publications
(33 citation statements)
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“…Previous work [1][2][3] has suggested that long-term use of artificial tears was proven to revitalise ocular surface integrity; however, short-term effects remain debatable. [4][5][6] Commercially available artificial tear products are unique as their mechanism of action depends on the formulation used by the respective manufacturers. These formulations are not only limited to types of lubrication agents, demulcents, and emollients, but also the addition and selection of preservatives.…”
Section: Introductionmentioning
confidence: 99%
“…Previous work [1][2][3] has suggested that long-term use of artificial tears was proven to revitalise ocular surface integrity; however, short-term effects remain debatable. [4][5][6] Commercially available artificial tear products are unique as their mechanism of action depends on the formulation used by the respective manufacturers. These formulations are not only limited to types of lubrication agents, demulcents, and emollients, but also the addition and selection of preservatives.…”
Section: Introductionmentioning
confidence: 99%
“…Analog zur TFT kommt es auch zu einem Anstieg der Tränenmeniskusparameter nach 1-maliger Verabreichung von topischen Lubrikanzien [52][53][54]. Auch scheint sich die Methode gut zur Therapieevaluierung über einen längeren Zeitraum zu eignen, z.…”
Section: Tränenfilmmeniskusunclassified
“…In addition, tear meniscus parameters differ between different types of dry eye and may therefore be valuable in differential diagnosis [ 45 ]. Single administration of topical lubricants increases tear meniscus parameters in healthy subjects as well as in patients with OSD and may therefore also be used as a marker for corneal residence time of eye drops [ 46 , 47 , 48 ]. Two-month treatment with topical cyclosporine increased tear meniscus height and volume in patients with dry eye, suggesting that this parameter might also be valuable in therapeutic monitoring [ 13 ].…”
Section: Imaging Modalitiesmentioning
confidence: 99%