Evaluation of Tablet Breaking Strength Testers

Goodhart, Frank W.; Draper, J. Ronald; Dancz, Douglas; Ninger, Fred C.

doi:10.1002/jps.2600620226

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…ODTs were prepared by direct compression [9,10] and evaluated for Hardness [11], weight variation [12], friability [13], content uniformity [14], disintegration time [15] and dissolution [16]. The % drug content was found in the range of 98.95 -101.21% (within the acceptable range) and the hardness was found between 3.94 -4.06 kg/cm 2 .…”

Section: Resultsmentioning

confidence: 99%

Taste Masking of Lornoxicam by polymer carrier system and formulation of oral disintegrating tablets.

et al. 2009

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Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties and belongs to the class oxicams. It is extremely bitter in taste. The purpose of this research was to develop a bitterless oral disintegrating tablet of Lornoxicam. Taste masking was done by complexing Lornoxicam with aminoalkyl methacrylate copolymer (Eudragit EPO) in different ratios. In vitro release profile obtained at pH 6.2 indicate that perceivable amount of drug will not be released in saliva while high percentage release (more than 80 % in 30 mins.) would be obtained at acidic pH 1.2 of the stomach. Three super disintegrants were used while preparing the tablets e.g. sodium starch glycolate, crospovidone and crosscarmellose sodium. The tablets were evaluated for different properties like drug content, hardness, friability and disintegration time. The tablets shown good taste and disintegration in oral cavity.

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Section: Resultsmentioning

confidence: 99%

Taste Masking of Lornoxicam by polymer carrier system and formulation of oral disintegrating tablets.

et al. 2009

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“…(Brook and Marshall, 1968). Several variants of tablet hardness testers ranging from manual to automatic are currently being utilized (Bavitz et al, 1973;Fairchild and Michel, 1961;Goodhart et al, 1973;McCallum et al, 1955).…”

Section: Current Pharmacopeial/non-pharmacopeial Methodsmentioning

confidence: 99%

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

Dave

Shahin

Youngren-Ortiz³

et al. 2017

International Journal of Pharmaceutics

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The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets. The irregularities associated with these attributes may influence the drug product functionality. Thus, an accurate and efficient characterization of these properties is critical for successful development and manufacturing of a robust tablets. These properties are mainly analyzed and monitored with traditional pharmacopeial and non-pharmacopeial methods. Such methods are associated with several challenges such as lack of spatial resolution, efficiency, or sample-sparing attributes. Recent advances in technology, design, instrumentation, and software have led to the emergence of newer techniques for non-invasive characterization of physical-mechanical properties of tablets. These techniques include near infrared spectroscopy, Raman spectroscopy, X-ray microtomography, nuclear magnetic resonance (NMR) imaging, terahertz pulsed imaging, laser-induced breakdown spectroscopy, and various acoustic- and thermal-based techniques. Such state-of-the-art techniques are currently applied at various stages of development and manufacturing of tablets at industrial scale. Each technique has specific advantages or challenges with respect to operational efficiency and cost, compared to traditional analytical methods. Currently, most of these techniques are used as secondary analytical tools to support the traditional methods in characterizing or monitoring tablet quality attributes. Therefore, further development in the instrumentation and software, and studies on the applications are necessary for their adoption in routine analysis and monitoring of tablet physical-mechanical properties.

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“…Similarly control tablets were compressed using pure drug instead of taste-masked microspheres. The fracture strength was measured with Monsanto tablet hardness tester[10]. …”

Section: Methodsmentioning

confidence: 99%

Development of Taste Masked Oral Formulation of Ornidazole

2010

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Taste masked microspheres of ornidazole were prepared using amino alkyl methacrylate copolymers (Eudragit E-100) by solvent evaporation technique. Taste assessment of these microspheres was done by both spectrophotometric taste evaluation technique and panel testing. Compressed tablets of taste masked ornidazole microspheres which rapidly disintegrated in the oral cavity were prepared using microcrystalline cellulose as directly compressible filler and sodium starch glycolate as a super-disintegrant. These were subsequently evaluated for various pharmacopoeial tests, drug release, and disintegration time in the oral cavity. Sensory taste evaluation was carried by panel testing in 20 healthy human volunteers. Results indicate successful formulation of oral fast disintegrating tablets which disintegrated in the oral cavity in about 30 s and possessed good taste.

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Evaluation of Tablet Breaking Strength Testers

Cited by 15 publications

References 6 publications

Taste Masking of Lornoxicam by polymer carrier system and formulation of oral disintegrating tablets.

Taste Masking of Lornoxicam by polymer carrier system and formulation of oral disintegrating tablets.

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

Development of Taste Masked Oral Formulation of Ornidazole

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