Evaluation of systemic oxidant/antioxidant status and paraoxonase 1 enzyme activities in psoriatic patients treated by narrow band ultraviolet B phototherapy

Pektaş, Suzan Demir; Akoğlu, Gülşen; Metin, Ahmet; Neşeli̇oğlu, Salim; Erel, Özcan

doi:10.1179/1351000213y.0000000061

Cited by 12 publications

(21 citation statements)

References 27 publications

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“…They concluded that with PASI50, PON-l activity and the total antioxidant capacity -TAC increase, whereas the CRP level, which correlates adversely with PON-l, drops. On the other hand, Pektas et al did not prove any changes in PON-l activity in 24 Turkish psoriatic patients following 30 phototherapy sessions with use of UVB narrowband lamps [10]. Similar observations were made by Kilic et al who did not report any increase in PON-l activity after 8 weeks of Methotrexate treatment in 28 Turkish patients [11].…”

Section: Discussionmentioning

confidence: 70%

Paraoxonase-1 and other factors related to oxidative stress in psoriasis

Oszukowska¹,

Kozłowska²,

Kaszuba³

2020

pdia

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A b s t r a c tIntroduction: Psoriasis is considered as a risk factor for atherosclerosis and contributes to myocardial infarction, ischemic heart disease and brain stroke. Aim: To estimate the atherogenic potential of psoriasis by analysing antioxidative and prooxidative factors (paraoxonase-1, α-tocopherol, uric acid, homocysteine), compare levels of these parameters between groups of psoriatic patients and healthy individuals as well as to analyse the impact of psoriasis severity and duration on the factors under the study and to define correlation between the marked factors and patients' lifestyles, body mass index (BMI) and abdominal circumference. Material and methods: The investigated group consisted of 66 patients with psoriasis vulgaris, while the control group comprised 30 persons. Both groups were comparable as regards their age, sex and BMI as well as abdominal circumference.Results: A significantly lower activity of paraoxonase-1 (p < 0.001), level of tocopherol (p < 0.05) and significantly higher concentration of homocysteine (p < 0.01), uric acid (p < 0.05) were found in patients with psoriasis as compared to the reference group. A higher homocysteine level occurs in patients with a negative family history of psoriasis (p < 0.05). In the group of patients with psoriasis and metabolic syndrome, the uric acid level was significantly higher (p < 0.05). Concentration of uric acid correlated negatively with the abdominal circumference value (p < 0.001). Conclusions: Psoriasis promotes arteriosclerosis development by decreasing the levels of antiatherogenic and increasing the levels of proatherogenic agents. Adverse changes in psoriatic patients involve activity of paraoxonase-1, levels of α-tocopherol, uric acid, homocysteine as compared to healthy individuals selected by their age, BMI and abdominal circumference value.

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Section: Discussionmentioning

confidence: 70%

Paraoxonase-1 and other factors related to oxidative stress in psoriasis

Oszukowska¹,

Kozłowska²,

Kaszuba³

2020

pdia

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“…Paraoxoase-1 (PON1) belongs to the group of antioxidants (calcium dependent esterase) [ 56 ], is an enzyme associated with HDL, and has anti-inflammatory functions [ 56 , 57 , 58 ]. This enzyme has paraoxonase (PON) and arylesterase (ARE) activities [ 59 ]. The level of PON1 in patients with Ps was lower compared to the control group [ 60 , 61 ]; and, after implementation of Ps treatment, PON1 levels were higher compared to the control group.…”

Section: Perspective Markers Of Oxidative Stress In Psmentioning

confidence: 99%

Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis

Pleńkowska

Gabig-Cimińska

Mozolewski

2020

IJMS

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This review discusses how oxidative stress (OS), an imbalance between oxidants and antioxidants in favor of the oxidants, increased production of reactive oxygen species (ROS)/reactive nitrogen species (RNS), and decreased concentration/activity of antioxidants affect the pathogenesis or cause the enhancement of psoriasis (Ps). Here, we also consider how ROS/RNS-induced stress modulates the activity of transcriptional factors and regulates numerous protein kinase cascades that participate in the regulation of crosstalk between autophagy, apoptosis, and regeneration. Answers to these questions will likely uncover novel strategies for the treatment of Ps. Action in the field will avoid destructive effects of ROS/RNS-mediated OS resulting in cellular dysfunction and cell death. The combination of the fragmentary information on the role of OS can provide evidence to extend the full picture of Ps.

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“…narrow-band ultraviolet phototherapy -NB-UVB) na parametry stresu oksydacyjnego i stężenie PON 1 u chorych na łuszczycę. Autorzy nie stwierdzili istotnego wpływu terapii NB-UVB na aktywność PON 1, jak również zależności pomiędzy aktywnością PON 1 i wskaźnikiem nasilenia łusz-czycy mierzonego skalą PASI [25]. Kilic i wsp.…”

Section: Paraoksonazaunclassified