In order to study the temperature characteristics of temperature-controlled wafer chuck and make its temperature uniformity meet the use requirements. In this paper, a structure of temperature-controlled wafer chuck is proposed firstly. On this basis, the fluid dynamics simulation model of the external flow field of temperature-controlled wafer chuck is built by using the Flow simulation software. By solving the model, the surface temperature map of the Vacuum chuck under the steady temperature of 125℃ is obtained. Secondly, the rationality of the model is proved by building a prototype for experiments, collecting the temperature data of each point on the surface of the Vacuum chuck and comparing the simulation data. Finally, based on the simulation model, the response surface experiment is designed and the maximum temperature difference regression equation is obtained, which provides great reference value for engineering designers.