Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

Haseeb, Muhammad Tahir; Hussain, Muhammad Ajaz; Bashir, Sajid; Ashraf, Muhammad; Ahmad, Naveed

doi:10.1080/03639045.2016.1257017

Cited by 34 publications

(20 citation statements)

References 32 publications

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“…[19] Evaluation of HES-Acetate as Sustained-Release Material: Caffeine was used as a model drug to examine the sustained-release behavior of HESacetate using a reported method. [20] Accordingly, powder blend of HES (300 mg) and caffeine (100 mg) were kneaded gently in a pestle and mortar by aqueous PVP K30 (5% w/v in isopropyl alcohol) solution to get a damp mass. This damp mass was then converted into uniform sized granules by passing through sieve no.…”

Section: Spectroscopic and Thermal Characterizationmentioning

confidence: 99%

Synthesis, Characterization, Isoconversional Analysis and Degradation Kinetics of Novel Acetate Coated Hydroxyethyl Starch: A New Candidate as a Drug Carrier

Abbas

Rizwan

et al. 2022

Starch Stärke

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The hydroxethyl starch (HES) is very trending biopolymer in biomedical field.In recent research we have successfully synthesized a novel ester of HES, i.e., HES-acetate by acetylation of HES followed by investigation of its thermal behavior. The successful acetylation of HES was confirmed by Fourier Transform Infrared (FTIR) and Proton-Nuclear Magnetic Resonance (1H NMR) spectroscopic techniques. Thermal stability and thermal degradation kinetics of HES-acetate were investigated by thermo-gravimetric analysis. Flynn-Waal-Ozawa model was fitted to the thermal data to find the values of thermodynamic triplet (𝚫S, 𝚫G and 𝚫E). Energy of activation (Ea) values of the major thermal degradation steps were found to be 242.85 and 287.17 kJ mol -1 for HES and HES-acetate, respectively. The order of degradation, integral procedural decomposition temperature (IPDT) and index of intrinsic thermal stability (ITS) were also taken into account. The results of the thermal analysis reveal that the HES-acetate gained significant thermal stability as compared to that of HES. This benign polysaccharide-based material was investigated for its potential in drug release studies by taking caffeine as a model drug. HES-acetate-based matrix tablets showed sustained release behavior of the drug indicating its potential for the development of oral delivery systems for sustained drug release.

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Section: Spectroscopic and Thermal Characterizationmentioning

confidence: 99%

Synthesis, Characterization, Isoconversional Analysis and Degradation Kinetics of Novel Acetate Coated Hydroxyethyl Starch: A New Candidate as a Drug Carrier

Abbas

Rizwan

et al. 2022

Starch Stärke

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“…Water swellable hydrogel is an integral component of a controlled/sustained release drug delivery system [4,40]. In vitro DS release studies were performed both in SGF (pH 1.2) for 2 h and in SIF (pH 6.8) for 10 h at 37 ∘ C. The drug release from a polymeric material depends upon the swelling and drug loading capability of the polymer followed by the drug solubility in the concerned media [41]. Poor swelling ability of BSH in acidic environment declines the penetration of media and also the drug is not solubilized from polymeric matrix.…”

Section: In Vitro Drug Release Study and Mechanismmentioning

confidence: 99%

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Lodhi

Hussain

Sher

et al. 2019

Advances in Polymer Technology

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This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swellingdeswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 m noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic. Recently, polysaccharide-based hydrogels have gained a lot of interest in drug delivery system due to their extraordinary swelling indices, stimuli responsive properties, biodegradability, biocompatibility, and nontoxicity [9][10][11][12][13].Ocimum basilicum L., (Syn: sweet basil in English, Babui tulsi in Hindi and Marathi, Rihan in Arabic, Niasabo in Gujrati, Jangli tulsi in Urdu, Tohrakhurasani in Persian, and Okimon in Unani) is a popular culinary and ornamental herb

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“…In the past decade or so, its initial utilization was reported as a gelling adhesive agent in combination with other polymers for buccal delivery [ 15 , 16 ] and colon targeting [ 17 ]. The swelling properties of the mucilage led to an investigation of their hydro-gelling potential; however, because of the lower mechanical strength, they were being used as an admixture with other polymers [ 18 , 19 ]. In our opinion, the graft copolymerization technique can help in fabricating harder and denser networks with enhanced mechanical strength of hydrogel with linseed mucilage.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Investigation of Linum usitatissimum Mucilage-Based Hydrogel as Possible Substitute to Synthetic Polymer-Based Hydrogels for Sustained Release Oral Drug Delivery

Mahmood

Erum

Mumtaz

et al. 2022

Gels

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The aim of this study was to investigate the potential of Linum usitatissimum mucilage, a natural polymer, in developing a sustained release hydrogel for orally delivered drugs that require frequent dosing. For this purpose, nicorandil (a model drug)-loaded hydrogels with various feed ratios of Linum usitatissimum mucilage, acrylamide (monomer) and methylene bis-acrylamide (crosslinker) were prepared. The newly synthesized hydrogel formulations were probed fundamentally with respect to swelling behaviour, solvent penetration, and the release of the drug from the hydrogels. Later, the selected formulations were further characterized by Fourier-transform infrared spectroscopy, thermal analysis, X-ray diffraction analysis, and scanning electron microscopy. The swelling coefficient demonstrated a linear relation with the polymer ratio; however, an inverse behaviour in the case of monomer and crosslinker was observed. The drug release studies, performed at pH 1.2 and 4.5 and considering the dynamic environment of GIT, demonstrated that all formulations followed the Korsmeyer–Peppas model, displaying a slow drug release via diffusion and polymer erosion. FTIR analysis confirmed the successful grafting of acrylamide on linseed mucilage. Furthermore, scanning electron microscopy revealed a clear surface morphology with folds and pinholes in the hydrogel. Therefore, based upon the in-vitro outcomes, it can be concluded that a promising sustained release hydrogel can be prepared from natural polymer, Linum usitatissimum mucilage, offering many-fold benefits over the conventional synthetic polymers for oral delivery of drugs.

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Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

Abstract: These finding indicates that LSH holds potential to be developed as sustained release material for tablet.

Cited by 34 publications

References 32 publications

Synthesis, Characterization, Isoconversional Analysis and Degradation Kinetics of Novel Acetate Coated Hydroxyethyl Starch: A New Candidate as a Drug Carrier

Synthesis, Characterization, Isoconversional Analysis and Degradation Kinetics of Novel Acetate Coated Hydroxyethyl Starch: A New Candidate as a Drug Carrier

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Preliminary Investigation of Linum usitatissimum Mucilage-Based Hydrogel as Possible Substitute to Synthetic Polymer-Based Hydrogels for Sustained Release Oral Drug Delivery

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