Evaluation of ^99mTc‐L‐methionine brain SPECT for detection of recurrent brain tumor: a pilot study with radiological and pathological correlation

Abstract

99mTc-L-methionine can be used as a SPECT tracer to differentiate tumor recurrence from post-radiation gliosis.

Evaluation of brain tumor recurrence by 99mTc-tetrofosmin SPECT: a prospective pilot study

“…Technetium99m-labeled compounds have also been studied and LGA low-grade astrocytoma, LGO low-grade oligodendroglioma, TF tetrofosmin, L/N lesionto-normal, R recurrence ( a histologically verifi ed recurrence), N necrosis proved advantageous over 201 Tl, due to the 140 keV γ-ray energy and high photon fl ux resulting in higher spatial resolution, with signifi cantly lower radiation burden to the patient [6,16]. 99m Tc-sestamibi, 99m Tc-methionine, and iodine-123-a-Methyl tyrosine ( 123 I-IMT) were proved suitable [17,18]. 99m Tc-tetrofosmine is a lipophilic diphosphine routinely used for myocardial perfusion imaging.…”

Metabolic Imaging of Brain Tumor by 99mTc-Tetrofosmin Scintitomography

“…Various natural amino acids have been labeled with radioactive isotopes -mostly PET-and are currently investigated. As regards SPECT, encouraging results were reported for 99m Tc-methionine and 123 I-IMT (Barai et al, 2004;Samnick et al, 2002). …”

Preclinical and Clinical Use of Indigenously Developed 99mTc-Diethylenetriaminepentaacetic Acid-Bis-Methionine: l-Type Amino Acid Transporter 1-Targeted Single Photon Emission Computed Tomography Radiotracer for Glioma Management

“…At least 17 different classes of transporters have been identified. Three systems are thought to transport neutral amino acids: system L, system A, and alanine-serine-cysteine (ASC) . The amino acid transport system L transports 11 C-L-MET into cells. , The increased protein synthesis and trans-methylation metabolic processes of tumors allow 11 C-L-MET to become incorporated into tumor molecules, resulting in 11 C-L-MET accumulation in malignancies …”

“…59 The amino acid transport system L transports 11 C-L-MET into cells. 59,60 The increased protein synthesis and trans-methylation metabolic processes of tumors allow 11 C-L-MET to become incorporated into tumor molecules, resulting in 11 C-L-MET accumulation in malignancies. 60 Development of amino acid-based tracers has been primarily focused on system L amino acid transport for PET imaging.…”