Evaluation of Subgingival Microflora in Diabetic and Nondiabetic Patients

Kumar, Vikas; Kumar, Kuchimanchi Phani; Gafoor, Abdul; Santhosh, Vediyera Chandroth

doi:10.5005/jp-journals-10024-1113

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Although some authors have reported that the microbial profiles of periodontitis are similar between patients with well‐controlled diabetes and patients without diabetes, 8 diabetes seems to lead to differences in the periodontal microbiota 9‐11 . In addition, periodontitis is more severe 12 and shows a faster rate of progression 13 in patients with diabetes compared with their counterparts without diabetes.…”

mentioning

confidence: 99%

Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three‐Month Randomized Clinical Trial

Raslan

Cortelli

Costa

et al. 2015

Journal of Periodontology

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confidence: 99%

Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three‐Month Randomized Clinical Trial

Raslan

Cortelli

Costa

et al. 2015

Journal of Periodontology

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“…Kumar et al (27) reported a very similar microbiological profile for diabetic and non-diabetic populations affected by periodontitis. Ciantar et al (28) identified significantly higher numbers of P. gingivalis, A. actinomycetemcomitans, Capnocytophaga spp.…”

Section: Discussionmentioning

confidence: 90%

Dental Implant Sites in Healthy versus Diabetic Subjects: A Two-Year Clinical and Bacteriological Assessment

Bignozzi

Ciobanu

Quaranta³

et al. 2013

Eur J Inflamm

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The aim of this study was to analyze by Real-Time Polymerase Chain Reaction (PCR) possible differences in periimplant microbiota of patients without significant systemic diseases versus patients affected by non-insulin-dependent diabetes mellitus (NIDDM), both treated with dental implants with the same implant-abutment system. Patients suffering from NIDDM, and those with no history of major systemic diseases, treated with dental implants at the Prosthodontics Operative Unit of “Sapienza” University of Rome in the period February 2009 - March 2010 were considered. Clinical parameters as well as microbiological profile were evaluated for each implant site at 3, 6,12, and 24 month follow-up. Crevicular fluid was collected for microbial sampling and analyzed by Real-Time PCR in order to identify the possible presence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum and Prevotella intermedia. Eight patients suffering from NIDDM and 22 with no history of major systemic diseases were included in the present investigation, each having received one to three dental implants. All the implants had been loaded 3 months after surgery, and the average follow-up after implant placement was 26.37±3.86. Clinical parameters showed no noticeable difference between the two groups, except for the Implant Stability Quotient (ISQ) that showed significantly lower values in NIDDM patients. A slightly higher amount of the considered pathogenic bacteria were retrieved in samples collected from patients with NIDDM (7.38×105) in comparison with those of healthy subjects (6.78×105), though the differences were below statistical significance. Within the limitations of the present study, a slight correlation was empirically detected between gene expression profiles of microbial populations and history of NIDDM, which however remained below the statistical significance. Further well-designed clinical studies may be useful to conclusively clarify the impact of subgingival microflora on the increased susceptibility of diabetic patients to periimplantitis.

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“…Others expanded this investigation by evaluating the subgingival microflora in both insulindependent and non-insulin-dependent diabetic patients with periodontitis. Although predominant organisms were identified in the insulin-dependent diabetic group, the study failed to establish statistically significant differences in subgingival microflora between diabetic and healthy individuals (Kumar et al, 2012).…”

Section: Type 1 Diabetes Mellitus and Oral Microbiotamentioning

confidence: 84%

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Vlachou,

Loume,

Giannopoulou

et al. 2024

Preprint

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Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected to rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes mellitus (T1DM), focusing on cellular and molecular mechanisms derived by the interplay between oral microbiota and the host immune response. A comprehensive search of literature published between 2008 and 2023 was conducted to elucidate the association between these two diseases. Preclinical and clinical evidence suggests a bidirectional relationship, with individuals with T1DM exhibiting heightened susceptibility to periodontitis, and vice versa. The review includes recent findings from human clinical studies, revealing variations in oral microbiota composition in T1DM patients, including increases in certain pathogenic species such as Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans, along with shifts in microbial diversity and abundance. Molecular mechanisms underlying this association involve oxidative stress and dysregulated host immune responses, mediated by inflammatory cytokines such as IL-6, IL-8, and MMPs. Furthermore, disruptions in bone turnover markers, such as RANKL and OPG, contribute to periodontal complications in T1DM patients. While preventive measures to manage periodontal complications in T1DM patients may improve overall health outcomes, further research is needed to understand the intricate interactions between oral microbiota, host response, periodontal disease, and systemic health in this population.

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Evaluation of Subgingival Microflora in Diabetic and Nondiabetic Patients

Cited by 4 publications

References 13 publications

Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three‐Month Randomized Clinical Trial

Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three‐Month Randomized Clinical Trial

Dental Implant Sites in Healthy versus Diabetic Subjects: A Two-Year Clinical and Bacteriological Assessment

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

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