Evaluation of SOX2 as a potential marker for ameloblastic carcinoma

Lei, Yu; Jaradat, Jumana M.; Owosho, Adepitan A.; Adebiyi, Kehinde Emmanuel; Lybrand, Kelley S.; Neville, Brad W.; Müller, Susan; Bilodeau, Elizabeth A.

doi:10.1016/j.oooo.2014.01.017

Cited by 49 publications

(58 citation statements)

References 28 publications

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“…More recently a study explored using SOX2 (sex determining region-Y-related high mobility group box2) immunohistochemical nuclear staining as a marker to identify areas in high-grade transformation in ameloblastic neoplasms [17]. The investigators used a scoring system with two parameters, percent of nuclei staining and intensity of staining.…”

Section: Ameloblastic Carcinomamentioning

confidence: 99%

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Malignant Odontogenic Tumors: An Update on Selected Tumors

Richardson

Müller

2014

Head and Neck Pathol

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This is an update on selected odontogenic malignancies. The article deals with aspects of recognized odontogenic carcinomas, odontogenic sarcoma and a yet unrecognized entity, sclerosing odontogenic carcinoma. Odontogenic malignancies are exceedingly rare, complicating a thorough understanding of the biologic behavior, reproducible standardized diagnostic criteria, appropriate classification and clinical management. Without the knowledge of the tumor's biologic behavior, adequate clinical management is difficult and patient outcomes uncertain. The histopathologic features are emphasized as well as the more recent biomarker findings. These recent advances may facilitate further understanding of this group of malignancies and provide useful stratification to guide patient management.

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Section: Ameloblastic Carcinomamentioning

confidence: 99%

“…Prior to this study the proliferative marker Ki-67 has been found to be markedly higher in AC than AB. The investigators concluded that use of SOX2 in conjunction with Ki-67 would aid in separating AC from AB and AA [17] (Fig. 2).…”

Section: Ameloblastic Carcinomamentioning

confidence: 99%

Malignant Odontogenic Tumors: An Update on Selected Tumors

Richardson

Müller

2014

Head and Neck Pathol

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“…Thus, morphological features including the cytological features of malignancy and a prominent infiltrative and destructive growth pattern are likely to be more useful [16]. However, a number of newer immunohistochemical markers have been suggested, such as nuclear SOX2 expression [47], and these may prove useful markers to identify malignant ameloblastic tumours.…”

Section: Malignant Odontogenic Tumorsmentioning

confidence: 99%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

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“…Yoon et al (29) found that the expression of cytokeratin 18, parenchymal matrix metalloproteinase (MMP)-2, stromal MMP-9 and Ki-67 differentiate AC from ameloblastoma. Lei et al (30) recommend the inclusion of SOX2 immunohistochemical staining in conjunction with Ki-67 in challenging cases with atypical features. Locally the tumor is invasive, often showing a silent infiltrative growth (30).…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature

et al. 2016

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Ameloblastic carcinoma (AC) is an uncommon malignant odontogenic tumor that can be difficult to differentiate from ameloblastoma and can arise directly as an undifferentiated lesion or from a pre-existing benign lesion. The current study presents a novel case of primary maxillary AC and review the literature on AC of the maxilla. The review of the literature indicates that secondary tumors and posterior localization are associated with a higher tendency for recurrence and, often, multiple recurrences. Surgical therapy, eventually followed by radiotherapy, is the treatment modality most frequently applied, while the role of chemotherapy remains unclear. Several new cases of maxillary AC have been recently described in literature, making this pathology more frequent than previously considered; this is perhaps an indication of an increased diagnostic sensibility, rather than a real increase in the incidence of the disease itself.

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Evaluation of SOX2 as a potential marker for ameloblastic carcinoma

Abstract: The diffuse nuclear staining pattern of SOX2 is suggestive of a high-grade process in ameloblastic neoplasms. Numerous aggregates of cells harboring dense nuclear stain should raise concern for a malignancy.

Cited by 49 publications

References 28 publications

Malignant Odontogenic Tumors: An Update on Selected Tumors

Malignant Odontogenic Tumors: An Update on Selected Tumors

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature

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