Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI

Vu, An T.; Beckett, Alexander; Setsompop, Kawin; Feinberg, David

doi:10.1016/j.neuroimage.2017.02.001

Cited by 15 publications

(15 citation statements)

References 48 publications

(52 reference statements)

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“…Muckli et al, 2015; for review see Lawrence et al, 2017), 0.65 mm isotropic over small regions (Heidemann et al, 2012); or even 0.45 mm using super resolution techniques (e.g. Vu et al, 2018). These high-resolution images allow the recording of blood oxygenation level dependent (BOLD, Ogawa et al, 1992) responses at the level of cortical layers and columns.…”

Section: Introductionmentioning

confidence: 99%

Multivoxel Pattern of Blood Oxygen Level Dependent Activity can be sensitive to stimulus specific fine scale responses

Vizioli

Martino

Petro

et al. 2019

Preprint

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1.AbstractAt ultra-high field, fMRI voxels can span the sub-millimeter range, allowing the recording of blood oxygenation level dependent (BOLD) responses at the level of fundamental units of neural computation, such as cortical columns and layers. This sub-millimeter resolution, however, is only nominal in nature as a number of factors limit the spatial acuity of functional voxels. Multivoxel Pattern Analysis (MVPA) may provide a means to detect information at finer spatial scales that may otherwise not be visible at the single voxel level due to limitations in sensitivity and specificity. Here, we evaluate the spatial scale of stimuli specific BOLD responses in multivoxel patterns exploited by linear Support Vector Machine, Linear Discriminant Analysis and Naïve Bayesian classifiers across cortical depths in V1. To this end, we artificially misaligned the testing relative to the training portion of the data in increasing spatial steps, then investigated the breakdown of the classifiers’ performances. A one voxel shift led to a significant decrease in decoding accuracy (p<.05) across all cortical depths, indicating that stimulus specific responses in a multivoxel pattern of BOLD activity exploited by multivariate decoders can be as precise as the nominal resolution of single voxels (here .8 mm isotropic). Our results further indicate that large draining vessels, prominently residing in proximity of the pial surface, do not, in this case, hinder the ability of MVPA to exploit fine scale patterns of BOLD signals. We argue that tailored analytical approaches can help overcoming limitations in high-resolution fMRI and permit studying the mesoscale organization of the human brain with higher sensitivities.

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Section: Introductionmentioning

confidence: 99%

Multivoxel Pattern of Blood Oxygen Level Dependent Activity can be sensitive to stimulus specific fine scale responses

Vizioli

Martino

Petro

et al. 2019

Preprint

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“…Combination of multi-slab and SMS has also been demonstrated in SLIDER, [38][39][40] where high resolution is achieved by super-resolution reconstruction 38,39 and RF encoding 40 rather than by the k z gradient encoding in the conventional multislab and SMSlab. Therefore, SLIDER is not affected by the inter-slab gap interference discussed in this work.…”

Section: Discussionmentioning

confidence: 99%

A 3D k‐space Fourier encoding and reconstruction framework for simultaneous multi‐slab acquisition

Dai

et al. 2019

Magnetic Resonance in Med

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Purpose To propose a novel 3D k-space Fourier encoding and reconstruction framework for simultaneous multi-slab (SMSlab) acquisition and demonstrate its efficacy in high-resolution imaging. Methods First it is illustrated in theory how the inter-slab gap interferes with the formation of the SMSlab 3D k-space. Then joint RF and gradient encoding are applied to remove the inter-slab-gap interference and form a SMSlab 3D k-space. In vivo experiments are performed to validate the proposed theory. Acceleration in the proposed SMSlab 3D k-space is also evaluated. Results High-resolution (1.0 mm isotropic) images can be reconstructed using the proposed SMSlab 3D framework. CAIPI sampling and 2D GRAPPA reconstruction can also be applied in the SMSlab 3D k-space. Compared with conventional multi-slab acquisition, SMSlab exhibits better SNR maintainability (such as lower g-factors), especially at high acceleration factors. Conclusion It is demonstrated that the joint application of RF and gradient encoding enables SMSlab within a 3D Fourier encoding framework. Images with high isotropic resolution can be reconstructed and further acceleration is also applicable. The proposed SMSlab 3D k-space can be valuable for both high-resolution and high-efficiency diffusion and functional MRI.

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“…New wavefront-shaping techniques permit complex 3D holography for precisely patterned optogenetic stimulation (Emiliani et al, 2015; Paluch-Siegler et al, 2015; Chaigneau et al, 2016; Conti et al, 2016;Hernandez et al, 2016). Novel channel opsins are being optimized for targeted, single-cell stimulation (Govorunova et al, 2016), as are photoswitchable receptors for precise interventions (Lin et al, 2015;Reiner et al, 2015;Berlin et al, 2016), and the toolbox for chemogenetic neuromodulation now has a novel designer ligand-receptor pair (English and Roth, 2015;Vardy et al, 2015). New strategies for noninvasive imaging and modulation include MR contrast agents for imaging calcium dynamics (Bartelle et al, 2016), which would revolutionize fMRI.…”

Section: Circuit-focused Tools and Maps For A New Era Of Neurosciencementioning

confidence: 99%

“…Initial data from these studies yielded insights into circuit processing in a variety of animals and neural systems. These include small organisms, such as the larval zebrafish (Bianco and Engert, 2015;Dunn et al, 2016; and fruit fly (Weir and Dickinson, 2015;Suver et al, 2016;Tuthill and Wilson, 2016;Weir et al, 2016), which allow comprehensive assays of entire circuits. In songbirds, learned behaviors can be studied on millisecond time scales aligned with neural activity (Liberti et al, 2016), and nonhuman primates offer neocortical brain regions that are direct orthologues of human counterparts (Sunkara et al, 2016).…”

Section: Circuit-focused Tools and Maps For A New Era Of Neurosciencementioning

confidence: 99%

The State of the NIH BRAIN Initiative

et al. 2018

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The BRAIN Initiative arose from a grand challenge to "accelerate the development and application of new technologies that will enable researchers to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought." The BRAIN Initiative is a public-private effort focused on the development and use of powerful tools for acquiring fundamental insights about how information processing occurs in the central nervous system (CNS). As the Initiative enters its fifth year, NIH has supported >500 principal investigators, who have answered the Initiative's challenge via hundreds of publications describing novel tools, methods, and discoveries that address the Initiative's seven scientific priorities. We describe scientific advances produced by individual laboratories, multi-investigator teams, and entire consortia that, over the coming decades, will produce more comprehensive and dynamic maps of the brain, deepen our understanding of how circuit activity can produce a rich tapestry of behaviors, and lay the foundation for understanding how its circuitry is disrupted in brain disorders. Much more work remains to bring this vision to fruition, and the National Institutes of Health continues to look to the diverse scientific community, from mathematics, to physics, chemistry, engineering, neuroethics, and neuroscience, to ensure that the greatest scientific benefit arises from this unique research Initiative.

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Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI

Cited by 15 publications

References 48 publications

Multivoxel Pattern of Blood Oxygen Level Dependent Activity can be sensitive to stimulus specific fine scale responses

Multivoxel Pattern of Blood Oxygen Level Dependent Activity can be sensitive to stimulus specific fine scale responses

A 3D k‐space Fourier encoding and reconstruction framework for simultaneous multi‐slab acquisition

The State of the NIH BRAIN Initiative

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