Evaluation of skin sensitization potential of jet fuels by murine local lymph node assay

Kanikkannan, Narayanasamy; Jackson, Tanise; Shaik, Madhu Sudhan; Singh, Mandip

doi:10.1016/s0378-4274(00)00212-5

Cited by 25 publications

(13 citation statements)

References 19 publications

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“…1 -8 More attention now is being given to JP-8-induced skin irritation and inflammation. 7,10,14,19 Because JP-8 jet fuel can act as an irritant, safe exposure levels of ground personnel to liquid and aerosol forms of JP-8 during refueling, handling of engine parts and fuel-tank maintenance should be identified.…”

Section: Discussionmentioning

confidence: 99%

“…Aliphatic components of this kerosene-based fuel were found in higher concentrations than aromatic components in rat skin after in vitro exposures. 9 Dermal exposure of rodents to JP-8 can lead to mild skin irritation 7,10 and petroleum middle distillates can cause chronic irritation and inflammation. 11 Such prolonged irritation may lead to tumor formation.…”

Section: Introductionmentioning

confidence: 99%

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Detection of oxidative species and low‐molecular‐weight DNA in skin following dermal exposure with JP‐8 jet fuel

Rogers¹,

Gunasekar²,

Garrett³

et al. 2001

J of Applied Toxicology

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Dermal absorption of JP-8 jet fuel can lead to skin irritation within hours after exposure. This study detected the formation of oxidative species and low-molecular-weight DNA in rat skin as potential indicators of JP-8-induced skin injury. At 0, 1, 2, 4 and 6 h after the beginning of a 1-h exposure, skin samples were removed and analyzed for oxidative species formation and low-molecular-weight DNA analysis. At 1, 2 and 4 h, mean oxidative species levels increased significantly (P < 0.05) above unexposed samples. Significantly higher (P < 0.05) low-molecular-weight DNA values were observed at 4 and 6 h compared with unexposed controls. These results demonstrate significant increases in oxidative species and low-molecular-weight DNA levels in the skin following dermal exposure to JP-8. These responses may serve as indicators of skin injury following exposure to JP-8 jet fuel and other volatile chemicals or mixtures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of oxidative species and low‐molecular‐weight DNA in skin following dermal exposure with JP‐8 jet fuel

Rogers¹,

Gunasekar²,

Garrett³

et al. 2001

J of Applied Toxicology

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“…(Deichmann et al 1955). Eine Untersuchung, der zufolge ein Treibstoff nach Zusatz von 25 ppm BHT im LocalLymph-Node-Assay eine etwas geringere Lymphozytenproliferation auslöste als der ursprüngliche Treibstoff (Kanikkannan et al 2000), ist für die Bewertung der hautsensibilisierenden Wirkung von BHT nicht geeignet. Zur atemwegssensibilisierenden Wirkung liegen keine Angaben vor.…”

Section: Allergene Wirkungunclassified

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 39. Lieferung, Ausgabe 2004 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkungen auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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“…Dermal toxicity studies have shown that JP-8 has a weak skin-sensitizing potential but is nonirritating to eyes [Cooper and Mattie, 1996;Kanikkannan et al, 2000]. Dermal absorption of JP-8 and JP-8ϩ100 varies with the hydrocarbon content of the fuels [Riviere et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

“…The aliphatic components are absorbed by the skin and aromatics penetrate most rapidly [McDougal et al, 2000]. Significant skin absorption of JP-8 and JP-8ϩ100 components such as tridecane, naphthalene, nonane, and toluene has been reported [Kanikkannan et al, 2000]. JP-8 exposure is linked to decreased immune organ weight and loss of viable immune cell numbers [Harris et al, 1997a,b].…”

Section: Introductionmentioning

confidence: 99%

DNA damage assessment by comet assay of human lymphocytes exposed to jet propulsion fuels

Jackman

Grant

Kolanko³

et al. 2002

Environ and Mol Mutagen

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Exposure to jet fuel damages DNA and results in a number of physiological changes in liver, lung, immune, and neurological tissue. In this study the single-cell gel electrophoresis assay or comet assay was used to compare the DNA damage in human peripheral lymphocytes produced by three jet propulsion fuels: JP-8, JP-5, and JP-8+100. These fuels consist of complex mixtures of aliphatic, aromatic, and substituted naphthalene hydrocarbons. Two exposure times were investigated which correspond to estimated occupational exposure times and concentrations of fuels were used that were based on previous fuel toxicity studies. Analysis of samples for the extent of DNA damage as determined by tail moment and percent tail DNA was performed on exposed cells following a brief recovery time. All fuels produced significant increases in DNA damage; however, only JP-8+100 was genotoxic at the lowest exposure concentration (1:500). At the highest exposure concentration (1:75), the mean tail moments for JP-8 and JP-8+100 (32.041 +/- 2.599 and 45.774 +/- 4.743, respectively) were significantly greater than for JP-5 (1.314 +/- 0.474). These results indicate that JP-8+100 is the most potent inducer of DNA damage in human peripheral lymphocytes and that both JP-8+100 and JP-8 are capable of damaging lymphocyte DNA to a greater extent than JP-5.

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Evaluation of skin sensitization potential of jet fuels by murine local lymph node assay

Cited by 25 publications

References 19 publications

Detection of oxidative species and low‐molecular‐weight DNA in skin following dermal exposure with JP‐8 jet fuel

Detection of oxidative species and low‐molecular‐weight DNA in skin following dermal exposure with JP‐8 jet fuel

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

DNA damage assessment by comet assay of human lymphocytes exposed to jet propulsion fuels

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