Evaluation of single and joint effect of metabolites isolated from marine sponges, Fasciospongia cavernosa and Axinella donnani on antimicrobial properties
“…salmonicida and A . hydrophila 296 . Furthermore, a novel natural protein, siganus oramin L‐amino acid oxidase, isolated from the serum of the rabbitfish Siganus oramin , showed antibacterial activity against the fish pathogenic bacteria A .…”
Section: Added Value Activities For Novel Aquafeedmentioning
confidence: 99%
“…Additionally, when combined, three metabolites, secomanoalide, dehydromanoalide and cavernosine, isolated from the sponge Fasciospongia cavernosa, had a synergistic antimicrobial effect against A. salmonicida and A. hydrophila. 296 Furthermore, a novel natural protein, siganus oramin L-amino acid oxidase, isolated from the serum of the rabbitfish Siganus oramin, showed antibacterial activity against the fish pathogenic bacteria A. sobria. Although this protein was isolated from a marine organism, the protein was produced using the yeast eukaryotic expression system, by genetic engineering tools.…”
Section: Added Value Activities For Novel Aquafeedmentioning
Climate Change Mitigation and Adaptation" call I "Ecosystem resilience increased" project "Impacts of invasive alien species and climate change on marine ecosystems in Estonia; Erasmus+ Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans,
“…salmonicida and A . hydrophila 296 . Furthermore, a novel natural protein, siganus oramin L‐amino acid oxidase, isolated from the serum of the rabbitfish Siganus oramin , showed antibacterial activity against the fish pathogenic bacteria A .…”
Section: Added Value Activities For Novel Aquafeedmentioning
confidence: 99%
“…Additionally, when combined, three metabolites, secomanoalide, dehydromanoalide and cavernosine, isolated from the sponge Fasciospongia cavernosa, had a synergistic antimicrobial effect against A. salmonicida and A. hydrophila. 296 Furthermore, a novel natural protein, siganus oramin L-amino acid oxidase, isolated from the serum of the rabbitfish Siganus oramin, showed antibacterial activity against the fish pathogenic bacteria A. sobria. Although this protein was isolated from a marine organism, the protein was produced using the yeast eukaryotic expression system, by genetic engineering tools.…”
Section: Added Value Activities For Novel Aquafeedmentioning
Climate Change Mitigation and Adaptation" call I "Ecosystem resilience increased" project "Impacts of invasive alien species and climate change on marine ecosystems in Estonia; Erasmus+ Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans,
“…NP due to their structural and functional complexity are highly considerable for antibiotic innovation. 75,76 The very first sesterterpenoid (60) found with antiinfectious activity, extracted from marine sponge Luffariella variabilis. 77 Axinellamines B-D separated from Australian species Axinella sp.…”
Section: Spongological Activitiesmentioning
confidence: 99%
“…NP due to their structural and functional complexity are highly considerable for antibiotic innovation. 75,76 Figure 13.Anti-bacterial compounds isolated from different sponges.…”
Section: Algae and Sponge—marine Nps Sourcesmentioning
Marine organisms are potentially a pretty good source of highly bioactive secondary metabolites that are best known for their anti-inflammation, anti-infection, and anti-cancer potential. The growing threat of bacterial resistance to synthetic antibiotics, is a potential source to screen terrestrial and marine natural organisms to discover promising anti-inflammatory and antimicrobial agents which can synergistically overcome the inflammatory and infectious disases. Algae and sponge have been studied enormously to evaluate their medicinal potential to fix variety of diseases, especially inflammation, infections, cancers, and diabetes. Cytarabine is the first isolated biomolecule from marine organism which was successfully practiced in clinical setup as chemotherapeutic agent against xylogenous leukemia both in acute and chronic conditions. This discovery opened the horizon for systematic evaluation of broad range of human disorders. This review is designed to look into the literature reported on anti-inflammatory, anti-infectious, and anti-cancerous potential of algae and sponge to refine the isolated compounds for value addition process.
A pair of enantiomeric sesterterpenoids, (±)‐hippolide J (1a and 1b), were isolated from the marine sponge Hippospongia lachne collected from the South China Sea. The racemic mixture was resolved into a pair of enantiomers, (–)‐1a and (+)‐1b, by chiral HPLC separation. The structures of the enantiomers were determined through ESI‐HRMS and NMR spectroscopic analysis, and their absolute configurations were determined by comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. Hippolide J (1) features an unusual bicyclo[4.2.0]octene core and contains three functional groups, namely, a hydroxymethyl group, an α,β‐unsaturated γ‐lactone fragment, and a characteristic prenyl side‐chain. The evaluation of the antifungal activity of (–)‐1a and (+)‐1b revealed that both show potent antifungal activity against three strains of hospital‐acquired pathogenic fungi, namely, Candida albicans SC5314, Candida glabrata 537, and Trichophyton rubrum Cmccftla, with MIC50 (minimum concentration to give 50 % inhibition) values of 0.125–0.25 µg/mL.
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