Evaluation of serum uric acid levels in psoriasis vulgaris

Abstract

IntroductionPsoriasis is an inflammatory and immune-mediated papulosquamous disease with unknown etiology. It is characterized by abnormal epidermal hyperproliferation and differentiation, and it affects 1%-2% of the population (1).Uric acid is an endogenously produced end-product of adenosine-and guanosine-based purine metabolism (2). A number of studies showed strong correlation among high uric acid levels, insulin resistance, and metabolic syndrome, which has been suggested to develop secondary to insulin resistance (3,4).Few studies in the literature investigated serum uric acid levels in patients with psoriasis, and those studies reported that the levels of uric acid could be correlated with the activity of psoriasis. However, none of those studies evaluated metabolic syndrome, which could directly affect the uric acid level.Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders such as cardiovascular diseases, hepatosteatosis, obesity, diabetes mellitus, hypertension, and hyperlipidemia. High serum uric acid levels are also associated with components of metabolic syndrome such as obesity, cardiovascular diseases, and hypertension. In our study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome into account, since it is one of the most important factors that affect serum uric acid levels. Material and methodsSeventy patients with psoriasis aged between 17 and 82 years who were untreated for psoriasis in the previous 6 months and 70 age-and sex-matched healthy subjects were included in this cross-sectional study. The Scientific Research Assessment Committee of our hospital approved the study protocol and all participants provided written informed consent.The demographic characteristics of the patients such as age and sex, as well as disease characteristics including dermatological examination, type of psoriasis, Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods:In this cross-sectional study, we evaluated 70 psoriasis patients and 70 healthy individuals who were matched with the patients according to the presence of metabolic syndrome. We evaluated the demographic features, levels of serum uric acid, Psoriasis Area Severity Index (PASI) scores, presence of psoriatic arthritis, nail involvement, and metabolic syndrome criteria of the patients.Results: Serum uric acid levels of psoriasis patients were significantly higher than thos...

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

“…Conflicting evidence was available for 14 of 137 laboratory markers: markers of bone metabolism (Dickkopf (DKK1) [ 52 , 53 ]; RANK-L [ 49 – 51 , 53 , 56 , 57 ]), markers of lipid metabolism (serum leptin [ 64 , 71 ]; total serum cholesterol [ 42 , 62 , 71 , 76 , 77 ]; total cholesterol: HDL ratio [ 42 , 76 ]; serum triglycerides [ 42 , 71 , 72 , 76 , 77 , 130 ]), inflammation markers (erythrocyte sedimentation rate (ESR) [ 43 , 44 , 47 , 56 , 62 , 66 , 70 , 74 , 75 ], cell numbers (platelet count [ 68 , 70 ]; white blood cell count [ 70 , 130 ]), cell phenotype (IL-17 secretion [ 58 , 59 ]), cytokine levels (IL-12/23 p40 [ 49 , 56 ]; macrophage colony-stimulating factor (M-CSF) [ 52 , 53 ]), uric acid [ 77 , 86 – 88 ], and antibodies against LL-37 [ 82 , 95 ].…”

Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

“…The extent of skin involvement, as measured by the PASI score, was not associated with HUC in the current study. Previous literature has provided some conflicting results as to whether HUC is related to the severity of psoriasis 8,10,11 or metabolic dysregulation 21,22 . It was reported that the serum uric acid is 1 of the determinants of the metabolic syndrome in nonpsoriatic patients; with 1 unit increase of serum uric acid, the odds of developing metabolic syndrome roughly doubled 22 .…”

“…Although several studies have shown a correlation between HUC and psoriasis, results were conflicting 10,11,12 . It is not clear whether HUC is correlated with the extent of skin involvement, or whether it results from the effects of coexisting features of the metabolic syndrome.…”

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

“…The metaanalysis consisted of two parts based on the type of response variable. The first part included the 27 studies (10,11,(14)(15)(16)(17)(18)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) that used continuous SUA as the response variable. These studies consisted of 31,314 participants (2,951 with psoriasis and 28,363 controls).…”