Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

Aljohani, Roaa; Polachek, Ari; Ye, Justine Yang; Chandran, Vinod; Gladman, Dafna D.

doi:10.3899/jrheum.170384

Cited by 33 publications

(27 citation statements)

References 29 publications

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“…Three other studies used a list of comorbidities to evaluate the impact of the number of reported comorbidities on PROs in PsA patients [14,88,95]. One of these studies, a prospective observational study with more than 600 patients with PsA, found that the presence of at least three comorbidities significantly worsened a patient's quality of life, as assessed with the SF- Abou-Raya/2014 [18] No data regarding the impact of comorbidity on PROs 2 Aguiar/2013 [20] No data regarding the impact of comorbidity on PROs 3 Aguiar/2013 [19] No data regarding the impact of comorbidity on PROs 4 Akhtari/2018 [21] No data regarding the impact of comorbidity on PROs 5 Aljohani/2017 [22] No data regarding the impact of comorbidity on PROs 6 Arancibia/2014 [24] No data regarding the impact of comorbidity on PROs 7 Arancibia/2015 [23] No data regarding the impact of comorbidity on PROs 8 Bandinelli/2009 [25] No numerical data provided 9 Batkaeva/2018 [26] No data regarding the impact of comorbidity on PROs [14]. A second study, a small prospective study, used the Functional Comorbidity Index (FCI) to corroborate that an increase in the number of comorbidities was significantly associated with moderate-severe work disability (OR 2.31, 95% CI 1.19-4.50).…”

Section: Resultsmentioning

confidence: 99%

The Impact of Comorbidity on Patient-Reported Outcomes in Psoriatic Arthritis: A Systematic Literature Review

et al. 2020

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Introduction: A systematic literature review was conducted with the aim to analyse the impact of comorbidity on patient-reported outcomes (PROs) in patients with psoriatic arthritis (PsA).(current and ex-smokers) had a negative impact on pain, function, fatigue, quality of life and overall health; alcohol intake had a negative impact on pain, function, fatigue, quality of life and overall health. Conclusions: The prevalence and impact of medical comorbidity on PROs are very high in patients with PsA.

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Section: Resultsmentioning

confidence: 99%

The Impact of Comorbidity on Patient-Reported Outcomes in Psoriatic Arthritis: A Systematic Literature Review

et al. 2020

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“…Other diagnostic tools include laboratory tests and imaging. Although no specific laboratory test is available for PsA, it is often characterized by negative results for rheumatoid factor and anti-citrullinated peptides, with possible laboratory abnormalities, including hyperuricemia, elevated C-reactive protein, and prolonged erythrocyte sedimentation rate [50,51]. Radiographs allow visualization of PsA-associated features (e.g., new bone formation), and magnetic resonance imaging provides visualization of soft tissue, facilitating the detection of enthesitis and spondylitis [52][53][54][55].…”

Section: Diagnosis Of Psamentioning

confidence: 99%

Psoriatic arthritis: the role of the nonphysician clinician in the diagnosis and treatment of patients with psoriasis

Overcash

Chillura

Fender

et al. 2021

Drugs Ther Perspect

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Psoriatic arthritis is a clinically heterogeneous, chronic, and progressive disease that develops in up to 30% of patients with psoriasis and is characterized by multiple and increasing joint defects caused by persistent immune-mediated inflammation. Several treatment options are available, including multiple biologic agents that inhibit specific cellular mediators of inflammation either directly or indirectly. Early detection and intervention are critical to preventing severe joint damage and pain, necessitating increased awareness and education about this disease for primary providers and nonphysician clinicians. Physician assistants and nurse practitioners, given their role in the primary care setting and within multiple specialty areas such as dermatology and rheumatology, are often the first to see patients who may have psoriatic arthritis. These healthcare providers are increasingly important in the early diagnosis and treatment of this disease. In this review, we provide an overview of psoriasis and psoriatic arthritis and discuss the multiple treatment options that are available for these patients. We also discuss ways to help recognize early joint involvement in the clinic and emphasize the role that nonphysician clinicians play in the care of patients with psoriatic arthritis. Key points Psoriatic arthritis, an inflammatory disease, may cause irreversible joint damage in patients with psoriasis. Physician assistants and nurse practitioners in dermatology and rheumatology, who are well positioned to recognize psoriatic arthritis early, treat patients, and prevent long-term complications, benefit from education on recognizing and treating psoriatic disease to improve outcomes. Biologics have demonstrated efficacy in several disease domains of psoriatic arthritis, and treatment guidelines generally recommend their use over that of nonbiologic agents.

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“…These include an increased level of uric acid, alcohol abuse, hypertension, the use of antihypertensives, increased body mass index (BMI) and familial history of gout (5). In addition, it has been reported that gout may be associated with persistent psoriasis especially in male patients and in those with other causes of hyperuricemia (6). Gout arthritis is most commonly seen in the metatarsophalangeal joint.…”

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confidence: 99%

Ayak İnterfalangeal Ekleminde Psöriazis İlışkili Gut Artriti: Olgu Sunumu

Öztürk¹

2020

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In this study, we present the first report of a case of gout arthritis localized in the interphalangeal joint of the right foot first toe, which was related to psoriasis disease in a 40-year-old male patient. Since the symptoms did not respond to conservative treatments, the patient was treated with surgery. Arthrotomy was performed to debride around the bones and intraarticular crystals. Then, pharmacological treatment was initiated and lifestyle changes were made. No recurrence of the symptoms was observed during a 24-month follow-up. AYAK İNTERFALANGEAL EKLEMİNDE PSÖRİAZİS İLİŞKİLİ GUT ARTRİTİ: OLGU SUNUMU ÖZETBiz bu çalışmada 40 yaşında erkek hastada, psöriazis hastalığı ile ilişkili, sağ ayak 1. parmak interfalangeal eklem lokalizasyonlu gut artritinin ilk raporunu yayımlıyoruz. Belirtiler konservatif tedavilere cevap vermediğinden, hasta cerrahi olarak tedavi edildi. Artrotomi yapılarak, kemiklerin çevresi ve eklem içi yerleşimli kristaller debride edildi. Ardından farmakolojik tedavi ve yaşam stili değişiklikliği uygulandı. 12 aylık izlemde semptomların rekürrensi olmamıştır.

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Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia

Abstract: HUC is common in patients with PsA, especially in those with longer disease duration and obesity. Proper control of HUC and metabolic diseases may play a preventive role in improving PsA outcomes.

Cited by 33 publications

References 29 publications

The Impact of Comorbidity on Patient-Reported Outcomes in Psoriatic Arthritis: A Systematic Literature Review

The Impact of Comorbidity on Patient-Reported Outcomes in Psoriatic Arthritis: A Systematic Literature Review

Psoriatic arthritis: the role of the nonphysician clinician in the diagnosis and treatment of patients with psoriasis

Ayak İnterfalangeal Ekleminde Psöriazis İlışkili Gut Artriti: Olgu Sunumu

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