Evaluation of Serum Trace Element Levels and Superoxide Dismutase Activity in Patients with Inflammatory Bowel Disease: Translating Basic Research into Clinical Application

Mohammadi, Erfan; Qujeq, Durdi; Taheri, Hassan; Hajian‐Tilaki, Karimollah

doi:10.1007/s12011-016-0891-0

Cited by 59 publications

(45 citation statements)

References 36 publications

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“…The serum trace element levels and superoxide dismutase activity in patients with IBD changes, compared to the healthy controls (28). In addition, use of antioxidants is an important complementary treatment in cardiometabolic, neurological, and gastrointestinal disorders (29), such as ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Vaghari‐Tabari¹,

Moein²,

Qujeq³

et al. 2017

Ann Colorectal Res

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Background: Ulcerative colitis is a common type of inflammatory bowel disease (IBD). The aim of the present study was to examine the relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients with ulcerative colitis. Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20 were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation coefficient test. P < 0.05 was considered statistically significant. Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitis in comparison with the healthy controls (P < 0.05). No significant correlation was observed between the MDA level and triglyceride, cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between HDL-C and MDA levels (r, -0.306; P < 0.05). Conclusions:The inverse correlation between HDL-C and MDA levels can be regarded as an indicator of the protective role of HDL-C against lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparison with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Vaghari‐Tabari¹,

Moein²,

Qujeq³

et al. 2017

Ann Colorectal Res

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“…Low levels of nitric oxide are thought to be physiological and protective, whereas its high levels as proinflammatory and injurious [ 32 ]. Recently, in CD patients, the overexpression of ROS and NO, as well as lower concentrations of numerous antioxidants, have been studied in intestinal mucosa or blood but not in saliva [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases: A Systematic Review

Nijakowski

Surdacka

2020

IJMS

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Saliva as a biological fluid has a remarkable potential in the non-invasive diagnostics of several systemic disorders. Inflammatory bowel diseases are chronic inflammatory disorders of the gastrointestinal tract. This systematic review was designed to answer the question “Are salivary biomarkers reliable for the diagnosis of inflammatory bowel diseases?”. Following the inclusion and exclusion criteria, eleven studies were included (according to PRISMA statement guidelines). Due to their heterogeneity, the potential salivary markers for IBD were divided into four groups: oxidative status markers, inflammatory cytokines, microRNAs and other biomarkers. Active CD patients manifest decreased activity of antioxidants (e.g., glutathione, catalase) and increased lipid peroxidation. Therefore, malondialdehyde seems to be a good diagnostic marker of CD. Moreover, elevated concentrations of proinflammatory cytokines (such as interleukin 1β, interleukin 6 or tumour necrosis factor α) are associated with the activity of IBD. Additionaly, selected miRNAs are altered in saliva (overexpressed miR-101 in CD; overexpressed miR-21, miR-31, miR-142-3p and underexpressed miR-142-5p in UC). Among other salivary biomarkers, exosomal PSMA7, α-amylase and calprotectin are detected. In conclusion, saliva contains several biomarkers which can be used credibly for the early diagnosis and regular monitoring of IBD. However, further investigations are necessary to validate these findings, as well as to identify new reliable salivary biomarkers.

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“…Many studies have shown that MPO expression in the intestinal mucosa is positively correlated with the severity of intestinal inflammation in UC, which can be used as a monitoring index for disease severity in UC patients [29]. MPO is abundant in neutrophils, which use hydrogen peroxide as an oxidant to oxidize tyrosine to tyrosyl.…”

Section: Logistic Regression Analysismentioning

confidence: 99%

No association of vitamin D binding protein gene polymorphisms with ulcerative colitis in Chinese patients

Qiu

Zhang

Wang

et al. 2019

Preprint

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Object Vitamin D (VD) deficiency has been reported in patients with ulcerative colitis (UC), and polymorphism in the gene encoding the vitamin D binding protein (DBP) can affect the characteristics of DBP, thus affecting the level and function of VD in vivo . Previous studies have rarely reported on the potential relationship between DBP polymorphisms and UC. To investigate the associations between genetic variants in DBP genes and UC susceptibility in the Han Chinese population, in order to discern whether any differences exist between this population and those of other countries.Methods In this case-control study, the genotyping of DBP rs4588 and rs7041 polymorphisms was conducted using polymerase chain reaction (PCR)-ligase detection reactions, and the rs4588 and rs7041 genotypes were detected by PCR-restriction fragment length polymorphism.Results In our case-control cohort, no significant difference was observed in the UC risk for either of the two SNPs (rs4588 and rs7401) in the DBP genes ( P > 0.05). No association between UC susceptibility and the DBP gene haplotypes was found either.Conclusions Our results suggest that the two SNPs (rs4588 and rs7401) in the DBP genes may have no correlation with susceptibility to UC in the Chinese Han population. But interestingly, haplotype GC, which contains the rs4588 and rs7041 variants in the DBP gene, may affect the level of oxidative stress in UC patients, especially the level of MDA.

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Evaluation of Serum Trace Element Levels and Superoxide Dismutase Activity in Patients with Inflammatory Bowel Disease: Translating Basic Research into Clinical Application

Cited by 59 publications

References 36 publications

Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases: A Systematic Review

No association of vitamin D binding protein gene polymorphisms with ulcerative colitis in Chinese patients

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