Evaluation of serum neutrophil gelatinase‐associated lipocalin in older patients with chronic kidney disease

Guo, Lulu; Zhu, Bei; Hai-chuan, Yuan; Zhao, Weihong

doi:10.1002/agm2.12098

Cited by 19 publications

(20 citation statements)

References 59 publications

(53 reference statements)

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“…In the elderly patients with CKD, serum NGAL has recently emerged to reflect renal impairment and to be closely related to Cystatin C, creatinine, urea, and eGFR. In a cohort of elderly 160 CKD patients (mean age 75.29 ± 12.08 years), Lulu Guo et al clearly demonstrated that NGAL levels increased progressively with the increase of 2- and 5-year risk of ESRD using the Kidney Failure Risk Equations (KFRE) [ 152 ]. Therefore, NGAL can be considered a novel and independent risk marker of kidney function decline in patients aged >50 years and >65 years with advanced CKD.…”

Section: The Diagnosis Of Aki In Older Populationmentioning

confidence: 99%

Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention

Infante

Franzin

Madio

et al. 2020

JCM

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Acute kidney injury (AKI), a critical syndrome characterized by a sudden reduction of renal function, is a common disorder among elderly patients particularly in Intensive Care Unit (ICU). AKI is closely associated with both short- and long-term mortality and length of hospital stay and is considered a predictor of chronic kidney disease (CKD). Specific hemodynamic, metabolic, and molecular changes lead to increased susceptibility to injury in the aged kidney; therefore, certain causes of AKI such as the prerenal reduction in renal perfusion or vascular obstructive conditions are more common in the elderly; moreover, AKI is often multifactorial and iatrogenic. Older patients present several comorbidities (diabetes, hypertension, heart failure) and are exposed to multiple medical interventions such as the use of nephrotoxic contrasts media and medications, which can also trigger AKI. Considering the emerging relevance of this condition, prevention and treatment of AKI in the elderly should be crucial in the internist and emergency setting. This review article summarizes the incidence, the risk factors, the pathophysiology, the molecular mechanisms and the strategies of prevention and treatment of AKI in elderly patients.

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Section: The Diagnosis Of Aki In Older Populationmentioning

confidence: 99%

Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention

Infante

Franzin

Madio

et al. 2020

JCM

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“…In patients with CKD, LCN2 is a fair indicator not only of disease progression [114] but also of nutrition, anemia, and inflammation [115]. We have recently found that LCN2 excess in patients with CKD positively correlates with FGF23 excess.…”

Section: Lipocalin-2 Regulates Fibroblast Growth Factor 23 Production...mentioning

confidence: 99%

Lipocalin-2: a novel link between the injured kidney and the bone

Courbon

David

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewFibroblast growth factor 23 (FGF23) excess is associated with left ventricular hypertrophy (LVH) and early mortality in patients with chronic kidney disease (CKD) and in animal models. Elevated Lipocalin-2 (LCN2), produced by the injured kidneys, contributes to CKD progression and might aggravate cardiovascular outcomes. The current review aims to highlight the role of LCN2 in CKD, particularly its interactions with FGF23. Recent findingsInflammation, disordered iron homeostasis and altered metabolic activity are common complications of CKD, and are associated with elevated levels of kidney-produced LCN2 and bone-secreted FGF23. A recent study shows that elevated LCN2 increases FGF23 production, and contributes to cardiac injury in patients and animals with CKD, whereas LCN2 reduction in mice with CKD reduces FGF23, improves cardiovascular outcomes and prolongs lifespan.

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“…Acute kidney insult indicators are regarded other markers such as neutrophil gelatinaseassociated lipocaline (NGAL) and kidney injury molecule 1 (KIM-1) (Schrezenmeier et al, 2017), (Xu et al, 2015). Unfortunately the NGAL is also manufactured to prevent its usage in the CF disease, in response to injured epithelial lung cells (Guo et al, 2020). Recent urine KIM-1 interests as an indicator for renal necrosis and regeneration have not been extensively assessed and CF usage trials have not been conducted.…”

Section: ⅱ Confirmation and Screening Of Renal Dysfunctionmentioning

confidence: 99%

Biochemical Aspects of Cystic Fibrosis and Kidney Disease: A Brief Discussion

Sabih

Mahmood

Jahangeer

et al. 2021

FCS

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Cystic fibrosis is a recessive autosomal disease. A nosographic entity that considered lethal in childhood. In organs such as the hypothalamus, kidney, and bone, the protein is directly affected, where its malfunction is likely to imply linear delays in growth, delayed pubertal onset, modulation of bone density, and susceptibility to renal calculus, which may be present in CF and have been in use for years, Nevertheless, the most researched and recognized cause of renal wound is iatrogenic in CF patients due to the consumption by pulmonary exacerbation of large doses of aminoglycosides (3-5 mg/kg/dose). The rise in the incidence of CF nephrocalcinosis does not seem to be connected to an inherent renal issue. Among fact, chronic kidney disease (CKD) prevalence in CF patients looks to be at least twice as high with a double rise every 10 years impacting over 20% of individuals older than 55 years. There has been no substantial change in proteome content in the treatment of CFTR modulators. These data indicate that a re-regulating proteasome activities adapts CF cells to the CFTR deficiency and impairs autophagy and endosomal aiming.

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Evaluation of serum neutrophil gelatinase‐associated lipocalin in older patients with chronic kidney disease

Cited by 19 publications

References 59 publications

Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention

Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention

Lipocalin-2: a novel link between the injured kidney and the bone

Biochemical Aspects of Cystic Fibrosis and Kidney Disease: A Brief Discussion

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