Evaluation of serum lactate dehydrogenase in oral squamous cell carcinoma, oral leukoplakia and oral submucous fibrosis

Rathore, Atul; Nagarajappa, Anil Kumar; Sreedevi,

doi:10.4103/0972-1363.167071

Cited by 9 publications

(24 citation statements)

References 1 publication

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“…The comparison of salivary LDH levels between OSMF and healthy subjects was statistically significant (p < 0.001). Our study findings were consistent with the study conducted by Sivaramakrishnan et al, 3 Kallalli et al, 1 Bhambal et al, 2 Shetty et al, 16 Rathore et al, 9 Pereira et al, 6 and Muralidhar et al 14 According to WHO 2005, oral leukoplakia is defined as a predominantly white patch or plaque that cannot be characterized clinically or pathologically as any other disorder; oral leukoplakia carries an increased risk of cancer development either in or close to the area of leukoplakia or elsewhere in the oral cavity or the head and neck region. 17 Malignant transformation rate of oral leukoplakia varies from 0.13 to 34%.…”

supporting

confidence: 83%

“…When serum LHD values were compared among oral cancer and control subjects, we found the LDH values were significantly higher in oral cancer group than healthy controls (p = 0.001). Our findings were in accordance with those of Rathore et al, 9 Joshi et al, 11 Pereira et al, 6 Hariharan et al, 13 Muralidhar et al, 14 and Görögh et al 15 We also found that salivary LDH levels in oral cancer cases were significantly higher than in control group. The comparison of salivary LDH levels between oral cancer and healthy subjects was statistically significant (p < 0.001).…”

supporting

confidence: 83%

“…6 Classic features may include a white lesion, red lesion, mixed red and white lesion, lump, and ulcer with exophytic raised margin. 9 The poor prognosis of oral cancer is owing to several factors including late diagnosis. 6 Oral cancer is often preceded by PMDs.…”

Section: Discussionmentioning

confidence: 99%

“…1 Most common PMDs are leukoplakia, OSMF, and lichen planus. 9 Diagnosis at early stage is the key to reduce mortality, morbidity, prognosis, and response to therapy. Early detection followed by appropriate treatment can increase cure rate to about 80% and can greatly improve the quality of life by minimizing extensive and debilitating treatments.…”

Section: Discussionmentioning

confidence: 99%

“…8 Increased LDH levels are due to increased mitotic index and more lactic acid production by tumor cells due to breakdown of glycoprotein. 9 It has been found that the serum LDH levels are increased in PMDs and malignancy. 6 With the above background, the aim of the study is to estimate and compare serum and salivary LDH in oral cancer and oral PMDs.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

Nandita¹,

Basavaraju²,

Pachipulusu³

2017

IJPCDR

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supporting

confidence: 83%

supporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

Nandita¹,

Basavaraju²,

Pachipulusu³

2017

IJPCDR

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Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

et al. 2020

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Background Increased levels of lactate dehydrogenase (LDH) as a tumor marker have been reported in malignant and some premalignant oral lesions such as oral lichen planus (OLP) and oral lichenoid reactions (OLRs). This study aimed to assess the level of total LDH in the saliva and serum of patients with oral squamous cell carcinoma (OSCC), OLP and OLRs. Methods In this case–control study, the participants were divided into four groups (n = 25) of healthy controls, OLP, OLRs, and OSCC. The serum and stimulated/unstimulated salivary levels of LDH were spectrophotometrically measured using standard LDH kits (Pars Azmoun). One-way ANOVA, Chi-square test, Pearson’s correlation test, and receiver operating characteristic (ROC) analysis were applied to analyze the data. Results The serum and salivary levels of LDH in OSCC patients were significantly higher than that the corresponding values in other groups (P = 0.0001). The serum level of LDH in OLR group was significantly higher than that in the control and OLP groups (P = 0.0001), but the difference in salivary level of LDH was not significant. The ROC analysis showed that both the serum and salivary levels of LDH had significant diagnostic ability for detection of OSCC and OLRs. Significant associations were noted between the serum and salivary levels of LDH. Conclusions Patients with OSCC and OLRs had higher serum levels of LDH than OLP and control groups. Further prospective longitudinal studies are required to assess the tissue level of LDH and monitor the transformation of OLRs because they have low rate of malignant transformation compared with other oral premalignant lesions.

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Prognostic Potential of Argyrophillic Nucleolar Organizer Regions (Agnors) in Oral Lesions: A Systematic Review

Singh

Bhargava

Ali

et al. 2022

Biosci., Biotech. Res. Asia

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Early detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is important for dental professionals to improve patient survival rates. More than half of patients with oral squamous cell cancer had advanced disease at the time of diagnosis, indicating a lack of early detection and risk assessment biomarkers. The development of new protein biomarkers will help in early diagnosis and treatment.The argyrophilic nucleolar organiser regions (AgNORs) staining technique is simple and cost-effective. These are replicatory markers that identify epithelial dysplasia. And it also plays a very important role in differentiating the benign, pre-malignant, and malignant lesions of the oral cavity. The number of AgNORs per cell has been considered an indicator of cellular proliferative activity. Microscopically, NORs can be identified as well-defined black dots located throughout the cell nucleus. The agNOR quantity is strictly proportional to the proliferative activity of the cell. AgNOR quantification helps in the determination of the degree of epithelial dysplasia and, consequently, in the analysis of its potential for malignant transformation. AgNOR qualitative characteristics help in differentiating hyperplastic, premalignant, and malignant oral lesions. The sliver staining technique is useful for studying the structure of the nucleolus as well as the variations in its activity. AgNORs are a valuable parameter in tumour pathology.

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Evaluation of serum lactate dehydrogenase in oral squamous cell carcinoma, oral leukoplakia and oral submucous fibrosis

Cited by 9 publications

References 1 publication

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

Prognostic Potential of Argyrophillic Nucleolar Organizer Regions (Agnors) in Oral Lesions: A Systematic Review

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