Evaluation of Serum HE4 in Ovarian Tumors, Its Comparison with Serum CA125 and Correlation with Histological Subtypes

Khati, Shikha; Jaiswal, Riddhi; Singh, Nisha

doi:10.1007/s40944-018-0232-7

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…In many studies, we see that at the end of treatment, the social health of cancer patients was lower than at the beginning of treatment (34). Accordingly, very little or no change in the quality of life score and especially the social health of patients is a success for researchers (29). Regarding the dimension of spiritual health, the obtained results are in line with the study of Golchin et al (35).…”

Section: Discussionsupporting

confidence: 87%

“…These monoclonal antibodies have been used to develop ELISA-based methods for measuring HE4 in postmenopausal women. Therefore, a higher level of expression indicates the progression of the disease and the deterioration of the patient (29). In this study, a significant decrease in HE4 gene expression after the intervention indicates the role of supportive and educational care of nurses in improving patients' physical health.…”

Section: Discussionmentioning

confidence: 59%

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The effect of supportive and educational nursing care on quality of life and HE4 gene expression in patients with ovarian cancer

Li¹,

Zhang²

2022

Cell Mol Biol (Noisy-le-grand)

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Ovarian cancer is one of the most common malignancies in women and is also the fifth leading cause of cancer death in women worldwide. In recent years, the survival rate of patients with this disease has been long, and at the same time, more emphasis is on their quality of life. Therefore, the present study was conducted to investigate the effect of supportive and educational care of nurses on the life quality of patients with ovarian cancer. The expression of the HE4 gene was also evaluated as a diagnostic marker of ovarian cancer to assess the role of supportive and educational care of nurses in improving the physical health of these patients. In this study, which was a quasi-experimental study, 45 patients with ovarian cancer participated. The instrument was demographic information and quality of life questionnaires related to Beckman Institute, which were completed in two stages before and after patients' training and support sessions. HE4 gene expression was also assessed by Real-time PCR technique. Finally, the obtained data were analyzed using SPSS software and statistical tests. Based on the results, the mean score of quality of life before the intervention was 51.73 ± 13.91, and after the intervention was 60.46 ± 13.80 (P <0.001). Also, in all four dimensions of quality of life, the mean score of individuals after the intervention increased compared to before the intervention, but this difference was recognized as significant in only two dimensions of physical and mental health (P <0.001). The results of HE4 gene expression also showed that supportive and educational care of nurses had a significant effect on the expression of this gene. Therefore, this study confirmed the positive effect of educational and supportive programs in improving the quality of life of patients with ovarian cancer. In general, the design and implementation of such programs are proposed more widely and based on patients' educational and supportive needs.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 59%

The effect of supportive and educational nursing care on quality of life and HE4 gene expression in patients with ovarian cancer

Li¹,

Zhang²

2022

Cell Mol Biol (Noisy-le-grand)

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“…However, CA125 has low specificity as it is also increased in benign endometriosis, endometrial and cervical adenocarcinoma, breast and colon cancer etc. 26,27 B. Serum HE4 (Human Epididymis protein) is used to monitor recurrence/progressive disease in patients with epithelial ovarian malignancy. Normally female genital tract and epididymal epithelium secrete HE4.…”

Section: Serum Markersmentioning

confidence: 99%

Observational study on serum markers and circulating tumor cells in ovarian cancer

Gupta¹,

Jaiswal²,

Tripathi³

et al. 2021

ACHR

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1) To detect Cyclophilin, APC and SFRP5 genes associated with Epithelial ovarian cancer by PCR. 2) To study and compare the prognostic and diagnostic efficacy of serological markers like Ca 125 and HE4 and their correlation with epithelial/ non epithelial ovarian neoplasms.Comparative observational study, Prospective study 64 cases fulfilling the inclusion criteria and giving their consent for inclusion in the study were enrolled as subjects of the present study over a period of one year. After DNA extraction (Invitrogen mini kit, USA) conventional PCR to amplify the extracted DNA and further subjected them to agarose gel electrophoresis for the identification(expression) of 3 genes i.e Cyclophillin, APC and SFRP5, was done; However, none expressed.ELISA was used to assess CA125 and HE4 pre and post surgical intervention. The serum markers were raised more in malignant epithelial ovarian cancer cases and levels plummeted after surgical intervention, as compared to benign masses. We could not establish correlation of the genes’ expression with the serum markers and histopathology. Combining HE4 and CA125 both might be more helpful than either of them using alone, in diagnosing as well as prognosticating ovarian diseases. A panel of multiple genes on a larger sample size may be needed for CTC detection.Early detection of ovarian tumors leads to early diagnosis and hence early institution of intervention and hence decreased morbidity and mortality.

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“…Shikha et alconcluded that, levels of both CA125 and HE4 were found to be raised in malignant cases, more in comparison to benign counterpart [3].…”

Section: Introductionmentioning

confidence: 97%

Evaluation of Serum s EGFR in Ovarian Tumors, its Comparison with Serum CA125, HE4 and Correlation with Histopathological Types

Chaudhary

Jaiswal

Singh

et al. 2021

Indian J Gynecol Oncolog

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Background and Objective EGFR is deregulated, in several types of cancer, by three mechanisms: (1) activating gene mutations; (2) overexpression of the EGFR transmembrane form and (3) altered ligand expression. Selective EGFR inhibitors have been suggested as first-line therapy in lung cancer patients harboring EGFR mutations, tumors of the pancreas and certain histotypes of ovarian tumors. Carbohydrate antigen 125(CA125) and Human Epididymis 4 are being used routinely for detection and follow up of ovarian cancer globally. Material and Methods A comparative observational study, over a 40 samples was carried out using Pre-operative and Postoperative Measurement of CA125 and HE4 by chemiluminescence and sEGFR by ELISA (Bioassay Technology Laboratory, Cat. No.E0313Hu). Results were compared between the three markers in various histological types of ovarian tumor using Statistical analysis (SPSS version 21.0). Results and Conclusion1. Mean pre-operative and post-operative values of sEGFR, CA125 and HE4 levels of malignant lesions were found to be higher as compared to those of benign lesions 2. Significant decline in EGFR was seen postoperatively in benign lesions but not in CA125 and HE4, while significant decline in CA125 and HE4 was seen postoperatively in malignant lesions but not in EGFR A combined panel of serum sEGFR, CA125, and HE4 increases the specificity and efficiency in ovarian cancer diagnosis.

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Evaluation of Serum HE4 in Ovarian Tumors, Its Comparison with Serum CA125 and Correlation with Histological Subtypes

Cited by 5 publications

References 20 publications

The effect of supportive and educational nursing care on quality of life and HE4 gene expression in patients with ovarian cancer

The effect of supportive and educational nursing care on quality of life and HE4 gene expression in patients with ovarian cancer

Observational study on serum markers and circulating tumor cells in ovarian cancer

Evaluation of Serum s EGFR in Ovarian Tumors, its Comparison with Serum CA125, HE4 and Correlation with Histopathological Types

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