Evaluation of Serum and Seminal Levels of Prostate Specific Antigen in Men With Spinal Cord Injury

Abstract

SCI patients have a significant decrease in total seminal PSA but total serum PSA is not affected by this lesion.

Prostate activity and prostate cancer in spinal cord injury

“…This finding suggests that some neurogenically mediated factor plays a role in the PSA production and that this spinal cord level (T7) represents a crucial point in the neurogenic stimulation of the prostate gland. Lynne et al 18 and Alexandrino et al 20 also found that seminal PSA concentrations obtained from patients were lower than those obtained from controls. However, in the study of Alexandrino et al, 20 total seminal PSA was lower in patients compared to controls regardless of lesion level with no difference between levels at T7 and below T7.…”

“…Lynne et al 18 and Alexandrino et al 20 also found that seminal PSA concentrations obtained from patients were lower than those obtained from controls. However, in the study of Alexandrino et al, 20 total seminal PSA was lower in patients compared to controls regardless of lesion level with no difference between levels at T7 and below T7. The results are shown in Table 3.…”

“…Variation in serum PSA among studies may be attributed to asymptomatic urinary tract infection in patients with a neurogenic bladder. It has been previously observed that subclinical prostatitis may be correlated with high serum PSA, 22 which may be an explanation for the results of Lynne et al 18 Serum prostate-specific antigen levels according to patient characteristics Most groups have demonstrated that patient characteristics, including a history of urinary tract infection, 18 a positive urine culture, 19 the bladder management techniques, 21 the level of SCI, 14,19,20 the completeness of the lesion, 14 or the duration of the lesion, 14,20 do not influence the serum PSA values in the SCI groups. However, the presence of a catheter was noted as an independent factor that were correlated with higher serum PSA values in this group in some studies.…”

“…[13][14][15][18][19][20][21] However, some conflicting results regarding serum PSA levels in SCI patients have been reported.…”

“…The results are shown in Table 3. 18,20,24 Prostate cancer diagnosis in men with spinal cord injury It has been theorized that central denervation of an organ is protective against malignancy and changes in Prostate activity and prostate cancer SCI HB Shim et al the hypothalamic-pituitary-gonadal axis but no persuasive data are available. Historically, since SCI patients rarely survived into the years during which prostate cancer becomes a significant medical issue, they were not screened and death from prostate cancer in patients with SCI was rare.…”