Evaluation of selected trace elements in male type 2 diabetic patients in Nnewi, south eastern Nigeria

Onah, Christian Ejike; Meludu, SC; Dioka, CE; Amah, Ubuo K.; Okwara, John E.; Osuji, CU

doi:10.4103/1658-600x.120848

Cited by 7 publications

(8 citation statements)

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“…In contrast, serum LH, FSH, and PRL concentrations should typically be between 1.4 and 18.1 mIU/mL, 1.5 to 9.3 mIU/mL, and 2.1 to 17.7 ng/mL, respectively (Chmitt et al, 2011). The current findings are consistent with earlier research that found lower testosterone levels (Rosen, 2004;Dhindsa et al, 2005;Stanworth & Jones 2009a;Stanworth et al, 2009b), higher prolactin serum levels (Mooradian et al, 1985;Onah et al, 2013;Rasheed et al, 2019), higher FSH level, and no significant difference in LH level (Onah et al, 2013). Other studies have shown, in contrast to our results, that type-2 diabetic patients have significant decreases in LH and FSH compared with healthy controls (Almihy et al, 2015;Xiaoxia et al,2017); type-2 people with diabetes have significantly higher LH levels than controls (Natah et al,2013); and there are no significant differences between type-2 diabetics and non-diabetics in serum levels of FSH and Te (Baccetti et al, 2002), (Rezvani, 2012).…”

Section: Resultssupporting

confidence: 93%

Profile and Role of Serum Hypothalamic-Pituitary-Testicular-Axis Hormones on Sexual Function of Older Men with Type-2 Diabetes

et al. 2023

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Little information is available on the complex endocrinology of sexual dysfunction, which is frequently associated with ageing and diabetes. We wanted to examine the serum profile of hypothalamic-pituitary-testicular-axis (HPTA) hormones and how they relate to sexual function in older men with type-2 diabetes. This study included 74 participants (44 type-2 diabetics and 30 healthy controls). The enzyme-linked immunosorbent assay (ELISA) method was used to measure serum levels of total testosterone (Te), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). Compared to controls, diabetic patients had significantly higher FSH and PRL levels but lower Te levels. Testosterone was found to be significantly correlated with sexual intercourse frequency (p<0.01), erectile function, and libido (p< 0.001). We discovered significant (p < 0.001) relationships between libido, penile erection, and FSH, as well as between PRL and libido (p< 0.05). When compared to the other hormones, testosterone had the strongest associations with the frequency of sexual intercourse (p< 0.05), libido (p< 0.05), and penile erection (p< 0.01). Our findings indicated that HPTA hormones might have a significant influence on sexual functions in type-2 diabetic patients, with Te being the most important HPTA hormone influencing sexual functions in diabetic patients. This study, therefore, helps to clarify the complex endocrinology and physiology of the sexual dysfunction frequently observed in older men with type-2 diabetes and also supports the use of testosterone replacement therapy in older diabetic adults.

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Section: Resultssupporting

confidence: 93%

Profile and Role of Serum Hypothalamic-Pituitary-Testicular-Axis Hormones on Sexual Function of Older Men with Type-2 Diabetes

et al. 2023

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“…These results are similar to others [12][13][14][15][16][17][18] . But some study did not find difference in serum chromium and selenium levels in between type 2 diabetic subjects and healthy control 19,20 .…”

Section: Discussionsupporting

confidence: 93%

“…This prolonged hyperglycemia increases the osmotic pressure of kidney tubules that inhibits the reabsorption of water by the kidney, resulting polyuria. Due to this polyuria increased excretion of chromium and selenium occur in type 2 diabetic patients [21][22][23][24] . As a result lower serum chromium and selenium levels increase the risk of diabetic complications like atherosclerosis, hypertension and coronary heart disease in type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Serum chromium and selenium levels in type 2 diabetes mellitus

Eva

Akhter²,

Alam³

et al. 2018

J Bangladesh Soc Physiol

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Background: Emerging evidence suggests that several trace elements such as serum chromium (Cr) and selenium (Se) levels are altered in type 2 DM and its deficiencies are associated with the development of diabetes related complications.Objective: To assess the serum Cr and Se levels in patients of type 2 diabetes mellitus.Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2014 to June 2015. Fifty type 2 diabetic patients with age ranging from 40 to 55 years were study group and fifty ages, BMI matched healthy subjects were control group. Patients were selected from Bangladesh Institute of Research for Diabetic Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka. Serum Cr and Se levels were estimated by flame atomic absorption spectrophotometry. For statistical analysis unpaired Student’s‘t’ test and Chi square test were performed.Results: In this study, serum Cr and Se levels were significantly (P<0.001) lower in patients than that of control group. In addition 20% patients had low Cr and 16% had Se deficiencies. Moreover, 6% of control had low Cr and 4% had low Se.Conclusion: From this study, it is concluded that serum Cr and Se deficiencies are associated with type 2 diabetes mellitus.Bangladesh Soc Physiol. 2017, December; 12(2): 72-75

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“…Higher mean serum zinc level of male diabetic patients in comparison to healthy controls was noticed in this study. This finding contrast with study carried out in Nnewi, in which they found that the concentrations of serum Zn in male patients with T2D are significantly lower than control subjects [8]. This may suggest that profiles differs among populations residing in different states, it may be related to variation in dietary composition according to state of residence.…”

Section: Discussioncontrasting

confidence: 80%

Evaluation of Zinc, Vitamin C and Vitamin E Levels in Male Subjects with Type 2 Diabetes Mellitus

Ositadinma

Martina

2020

IJTDH

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Aim: The aim of this study was to determine the serum/plasma levels of zinc, vitamin C and E in male subjects with type 2 diabetes mellitus to establish their concentration pattern. Place and Duration of Study: Medical outpatient clinic, Chemical Pathology Laboratory of Enugu State University of Science and Technology Teaching Hospital, between January and December 2016. Methodology: This prospective cohort study enrolled 40 male individuals with type 2 diabetes mellitus and 40 apparently healthy control, within the age range of 45-75 years. Zinc, vitamin C, vitamin E, and fasting blood glucose levels were determined at pre-treatment, six months and 12 months into treatment. Results: The mean values of zinc, vitamin E and fasting blood glucose were significantly higher at pre-treatment compared to apparently healthy control values (147. 76 +/- 32.95 vs 114.31+/- 15.58 µg/dl, 11.88 +/- 3.13 vs 3.42 +/- 0.21 mg/dl and 8.08 +/- 3.22 vs 5.25+/- 0.35 mmol/l respectively) (p=<0.001, <0.001, and <0.001 respectively). At 6 month into treatment in comparison to pre-treatment values, there were significant decreases in vitamin C (3.90+/-0.97 vs 5.15+/-1.43 mg/dl) (p= 0.04). At 12 month into treatment in comparison to pre-treatment values, there were significant decreases in vitamin C (3.25+/-0.16 vs 5.15+/-1.43 mg/dl) (p= <0.001). At pre-treatment, vitamin C significantly decrease from 6.49 +/- 0.96 mg/dl in age group 45-64 years to 4.10 +/- 0.76 mg/dl in age >65 years (p=0.01). Conclusion: The levels of vitamin C were lower at six months, but lowest at 12 month into treatment. Also vitamin C levels were found to be lower in age >65 years.

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Evaluation of selected trace elements in male type 2 diabetic patients in Nnewi, south eastern Nigeria

Cited by 7 publications

References 0 publications

Profile and Role of Serum Hypothalamic-Pituitary-Testicular-Axis Hormones on Sexual Function of Older Men with Type-2 Diabetes

Profile and Role of Serum Hypothalamic-Pituitary-Testicular-Axis Hormones on Sexual Function of Older Men with Type-2 Diabetes

Serum chromium and selenium levels in type 2 diabetes mellitus

Evaluation of Zinc, Vitamin C and Vitamin E Levels in Male Subjects with Type 2 Diabetes Mellitus

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