Evaluation of selected insomnia predictors in adolescents and young adults with cystic fibrosis

Tomaszek, Lucyna; Cepuch, Grażyna; Pawlik, Lidia

doi:10.5507/bp.2018.009

Cited by 13 publications

(15 citation statements)

References 44 publications

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“…Our study showed a high prevalence of insomnia in clinically stable adult CF patients (43%), which is closely comparable to that a previous study in CF young adults, using AIS (41.7%) (12). For comparison, the prevalence of insomnia in healthy young adults (25-34 years old) is about 18% in France, according to a large epidemiological study conducted in 2001 (39).…”

Section: Discussionsupporting

confidence: 89%

“…Sleep disruption is also a common complaint in CF children (5) that contributes to impaired daytime functioning and quality of life (6). In adults, CF-related sleep quality has been the primary focus of a small number of studies (7) (8) (9) (10) (11) (12). As the most common cause of both morbidity and mortality in CF patients is respiratory disease (13), most of these studies focused on the associations between sleep quality and impaired lung function.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to lung function, other factors are likely to impair sleep quality in CF adult patients such as night-time symptoms (cough (14), pain (15)), restless legs syndrome (RLS) (16) (17), anxiety and depression (12) (18), sleep-related breathing disorders (19) (20) or unhealthy lifestyle.…”

Section: Introductionmentioning

confidence: 99%

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Insomnia in adults with cystic fibrosis: strong association with anxiety/depression and impaired quality of life

Mulette

Ravoninjatovo

Guguen

et al. 2020

Preprint

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Background: While sleep disruption is a common complaint among children with cystic fibrosis (CF), only a few studies have investigated insomnia in adults. The aim of this study was to identify factors associated with insomnia in clinically stable adult CF patients.Methods: Twenty-eight CF patients (18M/10F), with a mean age of 28.2 ± 8.5 (mean ± standard deviation) years and a mean forced expiratory volume in one second of 69 ± 31% predicted completed questionnaires on insomnia (Insomnia Severity Index, ISI), sleep quality (PSQI), daytime sleepiness (Epworth), restless legs syndrome (IRLS), pain (NRS), anxiety/depression (HAD) and quality of life (CFQ-R 14+). Respiratory assessment data, including symptoms, sputum analysis, arterial blood gases, 6-minute walking test, pulmonary function tests and polysomnographic variables, were also analyzed. Results: Forty-three percent of patients were insomniac (ISI > 7). Compared with non-insomniac patients (ISI ≤ 7), insomniac patients had more severely impaired quality of life and a higher HAD score: mean anxiety score of 8.9 ± 2.4 vs 4.0 ± 2.4 (p <0.001), mean depression score of 7.3 ± 3.4 vs 2.1 ± 2.2 (p <0.01), with a positive correlation between ISI and HAD anxiety/depression scores (r=0.674/r=0.724, respectively, p <0.001). Insomnia was also associated with restless legs syndrome, pain and lower SpO2 during sleep. Conclusions: The strong association between insomnia, impaired quality of life and increased HAD score should prompt physicians to be particularly attentive to the management of anxiety and depression in adult CF patients with insomnia.Trial registration: on clinicaltrials.gov (NCT02924818)

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Insomnia in adults with cystic fibrosis: strong association with anxiety/depression and impaired quality of life

Mulette

Ravoninjatovo

Guguen

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Children with CF report poor sleep quality with difficulties initiating sleep, frequent awakenings, snoring, and trouble breathing (24–29). Daytime sleepiness is also a problem for these children (24, 25, 30–32).…”

Section: Poor Sleep Qualitymentioning

confidence: 99%

Sleep disturbances and their impact in pediatric cystic fibrosis

Shakkottai

O’Brien

Nasr

et al. 2018

Sleep Medicine Reviews

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Cystic fibrosis is a chronic, life-shortening illness that affects multiple systems and results in frequent respiratory infections, chronic cough, fat malabsorption and malnutrition. Poor sleep is often reported by patients with cystic fibrosis. Although objective data to explain these complaints have been limited, they do show poor sleep efficiency and frequent arousals. Abnormalities in gas exchange are also observed during sleep in patients with cystic fibrosis. The potential impact of these abnormalities in sleep on health and quality of life remains largely unstudied. This review summarizes what is known about sleep in children with cystic fibrosis, and implications for clinical practice. This report also highlights new evidence on the impact of sleep problems on disease-specific outcomes such as lung function, and identifies areas that need further exploration.

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“…Dancey and colleagues found an association between poor sleep quality and difficulties concerning serial addition and subtraction tasks in adult CF patients [ 47 ]. Children and adults with CF who report poor subjective sleep quality also report reduced quality of life [ 48 ], especially among the adolescents, including physical, social and emotional functioning; vitality; and health perception [ 45 ]. Poor mood is another consequence of inadequate sleep among CF children [ 49 ].…”

Section: Psychological Symptoms and Neuronal Impairment In Cfmentioning

confidence: 99%

Impact of Physical Activity on Cognitive Functions: A New Field for Research and Management of Cystic Fibrosis

et al. 2020

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Cystic Fibrosis (CF) is a genetic disease inherited by an autosomal recessive mechanism and characterized by a progressive and severe multi-organ failure. Mutations in Cystic Fibrosis Conductance Regulator (CFTR) protein cause duct obstructions from dense mucus secretions and chronic inflammation related to organ damage. The progression of the disease is characterized by a decline of lung function associated with metabolic disorders and malnutrition, musculoskeletal disorders and thoracic deformities, leading to a progressive decrement of the individual’s quality of life. The World Health Organization (WHO) qualifies Physical Activity (PA) as a structured activity produced by skeletal muscles’ movements that requires energy consumption. In the last decade, the number of studies on PA increased considerably, including those investigating the effects of exercise on cognitive and brain health and mental performance. PA is recommended in CF management guidelines, since it improves clinic outcomes, such as peripheral neuropathy, oxygen uptake peak, bone health, glycemic control and respiratory functions. Several studies regarding the positive effects of exercise in patients with Cystic Fibrosis were carried out, but the link between the effects of exercise and cognitive and brain health in CF remains unclear. Animal models showed that exercise might improve learning and memory through structural changes of brain architecture, and such a causal relationship can also be described in humans. Indeed, both morphological and environmental factors seem to be involved in exercise-induced neural plasticity. An increase of gray matter volume in specific areas is detectable as a consequence of regular training in humans. Neurobiological processes associated with brain function improvements include biochemical modifications, such as neuromodulator or neurohormone release, brain-derived neurotrophic factor (BDNF) production and synaptic activity changes. From a functional point of view, PA also seems to be an environmental factor enhancing cognitive abilities, such as executive functions, memory and processing speed. This review describes the current state of research regarding the impacts of physical activity and exercise on cognitive functions, introducing a possible novel field of research for optimizing the management of Cystic Fibrosis.

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Evaluation of selected insomnia predictors in adolescents and young adults with cystic fibrosis

Cited by 13 publications

References 44 publications

Insomnia in adults with cystic fibrosis: strong association with anxiety/depression and impaired quality of life

Insomnia in adults with cystic fibrosis: strong association with anxiety/depression and impaired quality of life

Sleep disturbances and their impact in pediatric cystic fibrosis

Impact of Physical Activity on Cognitive Functions: A New Field for Research and Management of Cystic Fibrosis

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