Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma

Sridharan, Gokul; Ramani, Pratibha; Patankar, Sangeeta; Vijayaraghavan, R.

doi:10.1111/jop.12835

Cited by 368 publications

(147 citation statements)

References 25 publications

(61 reference statements)

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“…In recent years, the role of saliva for early detection of oral cancer has been intensively studied [30][31][32][33]. Due to the fact that saliva can be collected in an easy and noninvasive way, it seems to be a very attractive diagnostic material [34].…”

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confidence: 99%

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Babiuch

Kuśnierz-Cabała

Kęsek

et al. 2020

JCM

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Background: Oral squamous cell carcinoma (OSCC) is a life-threatening disease. It could be preceded by oral potentially malignant disorders (OPMDs). It was confirmed that chronic inflammation can promote carcinogenesis. Cytokines play a crucial role in this process. The aim of the study was to evaluate interleukin-1alpha (IL-1α), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-α) in tissue specimens and saliva of patients with OSCC and OPMDs. Methods: Cytokines were evaluated in 60 tissue specimens of pathological lesions (OSCCs or OPMDs) and in 7 controls (normal oral mucosa, NOM) by immunohistochemistry and in saliva of 45 patients with OSCC or OPMDs and 9 controls (healthy volunteers) by enzyme-linked immunosorbent assays. Results: Immunohistochemical analysis revealed significantly higher expression of IL-8 in OSCC specimens and TNF-α in OSCCs and OPMDs with dysplasia as compared to NOM. Moreover, expression of TNF-α was significantly higher in oral leukoplakia and oral lichen planus without dysplasia, whereas expression of IL-8 only in oral leukoplakia without dysplasia in comparison with NOM. Salivary concentrations of all evaluated cytokines were significantly higher in patients with OSCC than in controls. Moreover, levels of IL-8 were significantly higher in saliva of patients with OPMDs with dysplasia as compared to controls and in OSCC patients as compared to patients with dysplastic lesions. There was also significant increase in salivary concentrations of IL-6, IL-8 and TNF-α in patients with OSCC as compared to patients with OPMDs without dysplasia. Conclusion: The study confirmed that proinflammatory, NF-kappaB dependent cytokines are involved in pathogenesis of OPMDs and OSCC. The most important biomarker of malignant transformation process within oral mucosa among all assessed cytokines seems to be IL-8. Further studies on a larger sample size are needed to corroborate these results.

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confidence: 99%

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Babiuch

Kuśnierz-Cabała

Kęsek

et al. 2020

JCM

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“…Recent investigations have proposed altered levels of s‐adenosylmethionine + pipecolinic acid, and the combination of ornithine, o‐hydroxybenzoate and ribose‐5‐phosphate may be early diagnostic markers for OSCC . Other candidate markers such as lactate, proline, glycine, citrulline, inositol trisphosphate, 2‐oxoarginine and glycerate‐2‐phosphate have all been proposed as putative markers for future validation studies …”

Section: Metabolomic Biomarker Combinationsmentioning

confidence: 99%

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Adeoye

Brennan

Thomson

2020

J Oral Pathology Medicine

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Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350 000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐tumour heterogeneity and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or “risk‐stratifying” saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.

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“…Traumatic mucosal injuries can result from accidental tooth bite, hard food, sharp edges of the tooth, hot food or excessive tooth brushing. Previous studies on salivary metabolics in oral leukoplakia have been done, which will help on the current topic (Sridharan et al, 2019). Some injuries can also be caused by iatrogenic damage during dental treatment or other procedures related to the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Traumatic oral mucosal lesions in elderly dental patients - An institutional study

Sherlin

Nivethigaa

2020

ijrps

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Oral trauma in elderly population constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function, which leads to loss of their capacity to respond to an injury. The aim of the study is to check the prevalence of traumatic oral mucosal lesions in elderly population/patients visiting a dental clinic. Elderly patients with oral mucosal lesions reported to dental hospitals were selected. Data from 86000 patients visiting Saveetha Dental College during the time period of June 2019 to March 2020 were reviewed, and the data was collected. This is a single centred retrospective study conducted in a private dental institution, Chennai. The collected data were tabulated and analysed using SPSS software by IBM. Out of 80 patients, 56.3% of the patients were of age 60 to 65 years. 42% of the patients had Denture stomatitis which was the highest among all the traumatic oral mucosal lesions. Males were more prevalent to oral mucosal lesions with 57.5% than females. The most common site with oral mucosal lesions is palate with 44%. The overall prevalence of traumatic oral mucosal lesions in the elderly population is high. Denture stomatitis is the most commonly occurring oral traumatic mucosal lesion among elderly patients visiting the dental clinic.

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Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma

Cited by 368 publications

References 25 publications

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Traumatic oral mucosal lesions in elderly dental patients - An institutional study

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