Evaluation of role of Low Molecular Weight Heparin and Vitamin E on renal functions in patients with diabetic nephropathy

Aggarwal, Hari Krishan

doi:10.5798/diclemedj.0921.2011.02.0001

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…[22,23] Hayvan deneyleri yanında 25 erişkin hasta üzerinde yapılan bir çalışmada da LMWH olan para-naprinin mikroalbuminüride belirgin azalmaya neden olduğu gösterilmiştir. [24] Yi-chih Lin ve ark. 'nın [16] derlemesinde de diyabetik böbrek hastalıkları tedavisinde kullanılan geleneksel ilaçlar listesinde de oral LMWH olan sulodexide'in mikroalbuminüriyi azalttığı ve eGFR üzerinde de olumlu etkileri olduğundan bahsedilmektedir.…”

Section: Discussionunclassified

The Effect of Low Molecular Weight Heparin on Microalbuminuria in Patients with Type II Diabetes Mellitus

Sertbaş¹

2020

bogazicitip

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Objectives: Diabetic nephropathy is one of the major complications of diabetes, with a frequency of 20-40% and high mortality. Different treatment modalities are required for the progression and prevention of nephropathy apart from the conventional treatment approaches. The present study aims to investigate the effects of low molecular weight heparin, Nadroparin on microalbuminuria. Methods: Forty-four Type II diabetic patients between the ages of 30-70 who were followed up from the internal medicine outpatient clinic and service were included in this study. Nadroparin, an LMWH for one month, was administered subcutaneously at a dose of 3075 IU to randomly selected 22 patients. The other 22 patients were followed up without any treatment as a control group. Results: There was a significant decrease in urea (43.2±18.3 and 34.9±7.9) and creatinine (1.13±0.32 and 0.9±0.3) values between basal and after 1-month treatment of Nadroparin (p<0.05). Meanwhile, there was not any significant difference between the basal values and values after in the control group (p>0.05). There was a slight increase ÖZET Amaç: Diyabetik nefropati %20-40 arasında değişen sıklıkla ve yüksek mortalitesi ile diyabetin major komplikasyonlarından biridir. Bilinen klasik tedavi yaklaşımları dışında nefropatinin ilerlemesi ve önlenmesi amacıyla değişik tedavi modaliteleri gerekmektedir. Bu çalışmanın amacı düşük molekül ağırlıklı heparin olan nadroparinin mikrolabuminüri üzerine etkilerini araştırmaktır. Yöntem: Çalışmaya dahiliye polikliniği ve servisinden takipli 30-70 yaşları arasında 44 Tip II Diabetes Mellituslu hasta dahil edildi. Bunlardan rastgele seçilen 22 hastaya 1 ay süreyle LMWH olan nadroparin 3075 IU dozunda günde iki kez deri altı verildi. Diğer 22 hasta kontrol grubu olarak herhangi bir tedavi almadan takip edildi. Bulgular: Nadroparin kullanan hastaların bazal ve 1 aylık tedavi sonrasında üre (43.2±18.3 ve 34.9±7.9) ve kreatinin (1.13±0.32 ve 0.9±0.3) değerlerinde anlamlı oranlarda azalma saptanmıştır (p<0.05). Bu arada kontrol grubunda bazal ve bir ay sonraki değerleri arasında anlamlı fark saptanmadı (p>0.05). Hastaların 1 aylık tedavi süresi sonrasında kreatinin klirensi değerlerinde istatistiksel olarak anlamlı olmayacak şekilde hafif bir artış saptandı (p>0.05). Nadroparin tedavisi sonrasında hastalarda %15'lik bir düşüş sağlansada mikroalbuminürideki değişimde (137.6±99.3 ve 116.4±114.1) anlamlı düzeylerde değildi. Sonuç: Sonuç olarak çalışmamızda istatistiksel olarak anlamlı olmasa da LMWH olan nadroparin uygulaması sonrasında mikroalbüminüri seviyelerinde belli oranlarda düşüş sağlanmış olup mikroalbuminürisi bulunan hastalarda standart tedavinin bir parçası olmasa bile tedavinin yetersiz kaldığı durumlar da dikkate alınması gerektiğini düşünmekteyiz.

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Section: Discussionunclassified

The Effect of Low Molecular Weight Heparin on Microalbuminuria in Patients with Type II Diabetes Mellitus

Sertbaş¹

2020

bogazicitip

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“…The damage of oxidative stress in people with diabetes mellitus can be resisted by a diet of high levels antioxidant food. One of antioxidant that serves to reduce oxidative damage in diabetics is vitamin E. According to Aggarwal et al, 4 vitamin E has been shown to reduce microalbuminuria and repair kidney damage in patients with diabetic nephropathy. The majority of natural supplements of vitamin E are in the form of D-alpha tocopherol.…”

Section: Introductionmentioning

confidence: 99%

Effect of D-Alpha Tocopherol Therapy towards Malondialdehyde Level and Histology of Kidney in Rattus norvegicus with MLD-STZ Induction

Mahardhian

Aulanni’am²,

Mahdi³

2013

J. Pure App. Chem. Res.

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Diabetic Nephropathy is a kidney disease which occurs due to complication of diabetes mellitus as a consequence of the damage of the kidney endothelial cells. Hyperglicemia condition in patients with diabetes mellitus that induces an oxidative stress, were related to endothelial cell damage. Oxidative stress as a result of hyperglycemia will activate a number of signal transduction pathways resulting in increase of free radicals. D-alpha tocopherol as one of antioxidant substance, that can act as an inhibitor of free radical chain reactions, play an important role in the reduction of the oxidative stress effect. Effect of D-alpha-tocopherol in reducing oxidative stress is identified by measuring the levels of malondialdehyde (MDA) in kidney and histology of kidney. This study used five groups mice; they were a control group, a diabetic group which was induced with MLD-STZ, and a therapeutic groups with a varieties doses of D-alpha tocopherol (100 mg/kgBW, 200 mg/kgBW and 300 mg/kgBW). The results showed that the D-alpha tocopherol was able to reduce the levels of malondialdehyde (MDA) and repair the histology of kidney of mice induced by MLD-STZ.

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Evaluation of role of Low Molecular Weight Heparin and Vitamin E on renal functions in patients with diabetic nephropathy

Cited by 2 publications

References 19 publications

The Effect of Low Molecular Weight Heparin on Microalbuminuria in Patients with Type II Diabetes Mellitus

The Effect of Low Molecular Weight Heparin on Microalbuminuria in Patients with Type II Diabetes Mellitus

Effect of D-Alpha Tocopherol Therapy towards Malondialdehyde Level and Histology of Kidney in Rattus norvegicus with MLD-STZ Induction

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