Evaluation of risk factors in patients diagnosed as bronchial asthma

Cengizlier, Mehmet Reha; Mısırlıoğlu, Emine Dibek

doi:10.1157/13084219

Cited by 15 publications

(7 citation statements)

References 13 publications

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“…In this study, the grass pollen and mite sensitivity rates in 289 AR Sensitivity % patients in the 1-18 years of age group were detected as 66.4% and 51.2%, respectively. The sensitivity rates found in our study were also comparable with the rates of other studies from Turkey as well as from abroad (14,15,20,21,(27)(28)(29). The high prevalence of pollen and mite sensitivity in Sakarya might be due to the damp weather and plant flora of the province, which has particular climatic features and is surrounded by the sea.…”

Section: Discussionsupporting

confidence: 91%

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

Elmas¹,

Özdemir²

2017

JAREM

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Objective: Sensitization prevalence studies have been rarely reported in children with allergic rhinitis from different regions of Turkey, and the exact rates of some sensitizations in humid regions such as Sakarya are still unknown. The aim of this study was to explore what kind of allergens play a role in sensitizations of allergic rhinitis patients during childhood in the Sakarya province of Turkey.Methods: This cross-sectional study involves 623 patients, 1-18 years of age, who have allergic rhinitis symptoms and were referred to the only pediatric allergy outpatient clinic in Sakarya between May 2013 and June 2015. Firstly, a questionnaire containing demographic data and patient history was completed. The multiple skin prick test system was used to detect sensitization. With 0 x 0 mm negative control, any positive test result with an allergen was defined as a wheal ≥3 mm diameter.Results: Overall, 289/623 (46%) children showed a positive response. 37% of them were found to have multiple sensitizations. Among the 289 patients, there were sensitizations to pollens (252/289: 87%), mites (51%), grasses (66%), trees (21%), molds (8%), animals (6%), and foods (6%). Sensitizations above 5 years of age were as follows: grasses, 72% (168/233); mites, 49.4%; trees, 24.5%; molds, 6.9%; and animals, 6%. Under 5 years were as follows: mites, 59% (33/56); grasses, 42.9%; foods, 25%; molds, 10.7%; trees, 5.4%; and animals, 3.6%.Conclusion: There were significant sensitizations detected for pollens and mites. Overall, a lower sensitization (8%) to molds is found in our patients who were referred to us from the humid Sakarya province.

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Section: Discussionsupporting

confidence: 91%

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

Elmas¹,

Özdemir²

2017

JAREM

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“…Longer asthma duration is frequently linked with poor disease control due to irreversible airflow obstruction. Asthma is a chronic disease with diverse clinical manifestations that favor T helper type 2 (TH2) response, whereby interleukins lead to the formation of immunoglobulin (Ig) E, pro-inflammatory cytokines and bronchial hyper-reactivity [44]. T cells, derived cytokines, IgE and mast cells initiate early asthmatic reaction and recruitment, whereby eosinophil activation was posited to play a role in the persistent asthma phenotype characterized by chronic airflow obstruction [45], which becomes irreversible after living with the disease for a long time.…”

Section: Discussionmentioning

confidence: 99%

Asthma Control and Its Predictive Factors in Adult Asthma Patients

et al. 2019

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BackgroundAsthma is a highly prevalent condition that remains difficult to control, as its associated factors remain poorly understood. Thus, the primary aim of the present investigation was to determine the prevalence of uncontrolled asthma in hospital units in south Jordan and to evaluate the risk factors that may contribute to uncontrolled asthma.MethodsThis was a cross-sectional study involving 93 patients aged 40.5 ± 13.6 years that met the criteria of the Global Initiative for Asthma (GINA). Relevant patient data were collected via a questionnaire and through a review of medical records. The questionnaire comprised of sections pertaining to sociodemographic and clinical characteristics, as well as pharmacological asthma treatment, asthma severity and asthma control. Asthma severity was determined in line with the GINA guidelines, whereby the patients were classified into four groups (intermittent, mild persistent, moderate persistent or severe persistent). Moreover, based on the findings yielded by the asthma control questionnaire (ACQ), patients were divided into three levels, whereby those diagnosed with partly controlled and uncontrolled asthma were combined into one group, denoted as “poorly controlled asthma”, with “uncontrolled asthma” and “controlled asthma” as the remaining two groups. Atopy was defined as one or more positive reactions (A/H ratio > 1) on a skin prick test.ResultsAsthma control was achieved in 45.2% of the sample. Moreover, older age, severe asthma according to the GINA guidelines, longer duration of asthma, atopy, being on treatment for asthma and history of allergic rhinitis were identified as the main risk factors contributing to poorly controlled asthma. Multivariate analyses, however, revealed that only atopy to two or more allergens and having severe asthmatic attacks were statistically significantly associated with poorly controlled asthma, for which the odds ratio Mantel-Haenszel (ORMH) of 17.2 and 2.2 was obtained, respectively.ConclusionOur findings indicate that severe asthma and atopy to two or more allergens are the main risk factors for uncontrolled asthma. However, further studies with larger sample sizes are needed to confirm these results.

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“…Asthma is a syndrome characterized by bronchial hyper‐responsiveness and reversible airflow obstruction, which produces recurrent respiratory symptoms in the form of shortness of breath, cough and wheeze. Several factors such as genetic, environmental, dietary change and occupational exposure are known to predispose to asthma (Kino & Oshima, 1989; Beckett, 1994; Homnick & Marks, 1998; Cengizlier & Misirlioglu, 2006; Maclennan et al , 2006). Numerous viral infections trigger acute asthma exacerbations.…”

Section: Introductionmentioning

confidence: 99%

Association ofMycoplasma pneumoniaeand asthma among Indian children

Varshney

Chaudhry

Saharan

et al. 2009

FEMS Immunology &Amp; Medical Microbiology

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The role of Mycoplasma pneumoniae infection as a trigger for asthma exacerbations is well supported in previous studies. This study was designed to investigate the role of M. pneumoniae infection in acute exacerbation of asthma in children. A total of 150 patients (110 males, 40 females) were studied and immunoglobulin M (IgM) antibodies to M. pneumoniae were detected by enzyme-linked immunosorbent assay (ELISA), and PCR amplification was performed for the P1 gene to associate M. pneumoniae infection with asthma. As compared with 33 children with asthma, only two of the control subjects had positive IgM titers for M. pneumoniae, which was statistically significant (P=0.002). A total of 15 children with asthma were positive by PCR for the P1 gene while none of the controls had a positive PCR. Of these positive cases, 24 cases were positive only by ELISA, six were positive only by PCR and nine patients were found to be positive by both ELISA and PCR. All the clinical characteristics of the patients at baseline were comparable between the moderate and the severe group of patients statistically, except for the peak expiratory flow rate. Mycoplasma pneumoniae infection was found to have a significant association with acute exacerbation in the moderate group of asthma patients by PCR (P=0.01). These data suggest that M. pneumoniae infection may contribute to asthma exacerbation.

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Evaluation of risk factors in patients diagnosed as bronchial asthma

Cited by 15 publications

References 13 publications

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

Asthma Control and Its Predictive Factors in Adult Asthma Patients

Association ofMycoplasma pneumoniaeand asthma among Indian children

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