Evaluation of Rheological Properties and Cytotoxicity of Bioinks

Abstract

We summarize the advantages and disadvantages of some of the most commonly used bioinks. We have probed the mechanical and cytotoxicity properties of Cellink and designed our own bioink from gelatin and Xanthan gum.

Embedded 3D bioprinting – An emerging strategy to fabricate biomimetic & large vascularized tissue constructs

“…The supportive medium should facilitate a biocompatible environment during printing and should not cause any damage during post–processing or removal of support structures [ 108 ]. The balance between the printing and curing time inside the support bath is crucial in determining the cell viability of the constructs.…”

Biomaterials in 3D Printing: A Special Emphasis on Nanocellulose

“…This is generally due to, high concentration of biomaterial in bioink prevents migration of cells and also prevents diffusion of nutrients due to entangled network, which ultimately results in decreased in cell viability. [25][26][27][28] Biodegradation: The degradability of bioink materials is another important factor during selection of bioink in 3D printing, an ideal bioink should be able to degrade in-vivo with time and at a controlled rate. Bioink is expected to create similar biological environment for growth of engineered tissue and the degraded products must be non-toxic to cells incorporated inside tissue.…”