Evaluation of retinal nerve fiber layer thickness and choroidal thickness in pseudoexfoliative glaucoma and pseudoexfoliative syndrome

Özge, Gökhan; Koylu, Mehmet Talay; Mumcuoğlu, Tarkan; Gündoğan, Fatih Ç.; Özgönül, Cem; Ayyıldız, Önder; Küçükevcilioğlu, Murat

doi:10.1080/00325481.2016.1170579

Cited by 22 publications

(21 citation statements)

References 32 publications

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Section: Discussionmentioning

confidence: 96%

“…Ozge et al in their study compared RNFL thickness in eyes with PXF glaucoma, PXF syndrome and healthy controls 15. They found out that RNFL thickness in all quadrants and average thickness was significantly low in PXF glaucoma eyes as compared to other groups, but RNFL thickness comparison between PXF syndrome and healthy control eyes did not show a significant difference except in infero temporal quadrant 15. Another interesting study by Rao et al evaluated clinical findings and peripapillary RNFL thickness in patients with unilateral and bilateral PXF syndrome and found out that bilateral cases with PXF were older (p < 0.01) and had thinner RNFL (p = 0.04) than unilateral cases 16…”

Section: Discussionmentioning

confidence: 99%

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Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Yasmeen

Fatima

Islam³

2016

Pak J Med Sci

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Objective:To compare mean retinal nerve fiber layer (RNFL) thickness in patients having pseudo exfoliation (PXF) with normal age matched controls using spectral domain optical coherence tomography (SD-OCT).Methods:This was a case control study conducted at Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi from 12 June 2013 to 12 January 2014. Seventy eyes (Group A - 35 patients with PXF and Group B - 35 healthy age matched subjects) of more than 40 years of age were included in the study. Intraocular pressure (IOP) was measured with Goldmann applanation tonometer (GAT) and peripapillary RNFL thickness was measured in four quadrants with SD-OCT (Topcon 3D OCT-1000 Mark II) in all subjects. Data was analyzed using the SPSS version 14.Results:Mean age of group A (PXF patients) was 65.63 ± 8.47 years and of group B (Healthy subjects) was 64.31 ± 6.51 years (p = 0.470). Both groups were gender matched with male preponderance (p = 0.673). Mean IOP in each group was 13.80 ± 2.59 mm Hg, and 13.49 ± 2.07 mm Hg respectively (p= 0.578). Mean average peripapillary RNFL thickness was 77.46 ± 12.17 µm in group A and 83.96 ± 10.58 µm in group B. Statistically significant differences were detected between two groups for mean average RNFL thickness (p= 0.020) and mean RNFL thickness in inferior quadrant (p=0.014).Conclusion:PXF patients with normal IOP and visual fields have thin RNFL as compared to healthy age matched controls. Therefore routine assessment and follow up of PXF patients with OCT may help in early diagnosis of PXF glaucoma.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Yasmeen

Fatima

Islam³

2016

Pak J Med Sci

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“…In contrast, Li et al [21] revealed choroidal thickening in primary angle-closure glaucoma, suggesting a lack of relationship between ChT and glaucomatous progression. Ozge et al [22] compared RNFL thickness and ChT in 18 patients with PEX glaucoma in one eye and PEX syndrome in the other and found nonsignificant ChT changes in both groups.…”

Section: Discussionmentioning

confidence: 99%

No Relationship between Visual Field Damage and Choroidal Thickness in Eyes with Primary Open-Angle Glaucoma

Karaca

Özge²,

Mumcuoğlu

et al. 2020

Ophthalmic Res

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To evaluate the association between visual field damage and choroidal thickness (ChT) in subjects with primary open-angle glaucoma. Methods: In this cross-sectional study, 115 eyes of 58 glaucoma patients and 112 eyes of 56 healthy subjects were enrolled. ChT at the fovea, 0.5 mm temporal, 1.5 mm temporal, 0.5 mm nasal, 1.5 mm nasal to the fovea, and all quadrants in the peripapillary region were analyzed. The subjects with glaucoma were further classified by Hodapp-Anderson-Parrish scores. Results: There was no difference between glaucoma and healthy subjects in mean age, gender, and refractive errors. The overall average thickness of the retinal nerve fiber layer (RNFL) was significantly lower in the eyes with glaucoma compared to the normal subjects (p < 0.01) and decreased in proportion to the severity of glaucoma (normal, 99.4; no defect, 89; early, 80.4; moderate, 63.1; and severe, 51 µm). ChT measured from the foveal region, at a distance of 500 μm from the fovea (nasal and temporal), and 1,500 μm from the fovea (nasal and temporal) did not significantly vary between the two groups. As well, peripapillary ChT did not significantly differ in proportion to the severity of glaucoma (p > 0.05 for all quadrants). The RNFL and ChT measurements were not significantly correlated with any peripapillary location (|r| ≤ 0.17, p > 0.05). The visual field mean deviation/pattern standard deviation and ChT measurements were also not significantly correlated with any peripapillary and macular location (|r| ≤ 0.12, p > 0.05). Conclusions: There was no significant difference in macular and peripapillary ChT between healthy and glaucomatous eyes that differed in severity of visual field damage. This suggests that the structural features of the choroid may not be associated with severity of primary open-angle glaucoma.

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“…27 Gokhan et al also reported that thinning of the RNFL was associated with the progression of PEX to pseudoexfoliation glaucoma. 28 Our study suggests that vascular risk factors are not present in TEX.…”

Section: Discussionmentioning

confidence: 55%

Peripapillary Perfused Capillary Density in True Versus Pseudoexfoliation Syndrome: An OCTA Study

Tangtammaruk

Petpiroon

Supakonatanasan

et al. 2020

Preprint

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PurposeTo compare peripapillary perfused capillary density (PCD) among eyes with true exfoliation syndrome (TEX), eyes with pseudoexfoliation syndrome (PEX), and healthy control eyes.Materials and MethodsIn this observational cross-sectional study, eyes with and without TEX or PEX were assessed by optical coherence tomography angiography (OCTA) imaging. Bilateral OCTA images (4.5 · 4.5 mm2) centered at the optic nerve head were obtained using a commercial spectral domain OCTA system. Optic nerve head perfusion was quantified using the split-spectrum amplitude decorrelation angiography algorithm. Categorical and continuous variables were compared using the chi-squared test and one-way analysis of variance, respectively. The generalized estimating equation was used to adjust for confounding factors and determine inter-ocular associations.ResultsWe enrolled 39 eyes with TEX, 31 eyes with PEX, and 32 control eyes. There were no significant differences among the three groups regarding age, intraocular pressure, cup-to-disc ratio, blood pressure, or axial length (all p>0.05). There were significant differences in global PCD among the three groups (p=0.01). There were significant differences in annular PCD between the TEX and PEX groups (p=0.027).ConclusionsWhile both global and annular PCDs did not differ between the TEX and control groups, greater loss of annular PCD in the PEX group than in the TEX and control groups suggests more pronounced microvascular disturbance in PEX.Synopsis/PrecisGreater microvascular attenuation in PEX compared with TEX and normal control measured by OCTA.

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Evaluation of retinal nerve fiber layer thickness and choroidal thickness in pseudoexfoliative glaucoma and pseudoexfoliative syndrome

Abstract: Thinning of the RNFL in association with unchanged ChT may mean that the presence of PEX material is a much more significant risk factor than choroidal changes in the progression of PEX syndrome to PEX glaucoma.

Cited by 22 publications

References 32 publications

Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

No Relationship between Visual Field Damage and Choroidal Thickness in Eyes with Primary Open-Angle Glaucoma

Peripapillary Perfused Capillary Density in True Versus Pseudoexfoliation Syndrome: An OCTA Study

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